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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nausea and emesis in early pregnancy is a common phenomenon affecting between 50% and 70% of pregnant women, but little is known about the etiology and possible function of this common and often incapacitating condition. Morning sickness has been reported to have a positive effect on pregnancy outcome and is associated with a decreased risk of miscarriage, preterm birth, low birth weight (LBW), and perinatal death. Both human and animal studies have shown that reduced energy intakes in early pregnancy are associated with increased placental weight. Based on evidence from the literature, a hypothesis is proposed that suggests a functional role for the nausea and emesis of pregnancy in stimulating early placental growth. It is suggested that morning sickness, resulting from secretion of hCG and thyroxine, reduces maternal energy intake. As a result, maternal levels of the anabolic hormones, insulin, and insulin growth factor-1 (IGF-1) are lowered. By suppressing maternal tissue synthesis in early pregnancy, we propose that nausea and vomiting in pregnancy helps ensure that nutrient partitioning favors the developing placenta. Evidence is also presented that suggests there may be a positive relationship between morning sickness and preconceptional body mass index (BMI), such that women who are underweight will experience less severe symptoms of morning sickness compared with women with normal preconceptional BMIs.
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PMID:Nausea and vomiting in early pregnancy: its role in placental development. 1077 46

In industrial countries more than half of women complain of nausea and vomiting during the first trimenon. Morning sickness, the common term of gestational nausea and vomiting, is usually temporary and harmless, it persists in less than 20% of all pregnancies. Maternal and fetal prognosis of uncomplicated emesis gravidarum is good. The responsible hormone as the pathogenetical trigger has not been defined yet, genetical and psychosocial factors may influence the intensity and duration of disease. The uncomplicated emesis has to be distinguished from hyperemesis gravidarum, a disorder which occurs in 0.3-2% of all pregnancies and is potentially of life-threatening character. While the uncomplicated form generally does not need any special therapy, hyperemesis gravidarum requires immediate compensation of fluid- and electrolyte loss, adequate supplementation of calories and vitamins as well as antiemetic therapy. Prospective studies have demonstrated that antihistamines are safe and effective for treatment of nausea and vomiting of pregnancy, in addition, also metoclopramide posses a high efficacy and safety profile.
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PMID:[Vomiting in pregnancy. When is it more than only a bothersome nuisance?]. 1461 Aug 62