Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since July 1976, 19 patients with carcinoma of the bladder have been treated with adriamycin, 5-fluorouracil, and levamisole combined with radiotherapy (60 Gy [6000 radsA1/24 fractions/6 weeks). Chemotherapy and radiotherapy were initiated simultaneously, with the entire treatment lasting 7--8 months. Three months after the completion of radiotherapy, 14 of the 18 patients in whom cystoscopy was performed were found to be in complete remission. Overall, 17 of the 19 patients have responded to the treatment and 15 patients have at some time shown complete remission. The toxic effects seen were myelosuppression, nausea, vomiting, diarrhea, loss of weight, and alopecia. Thirteen patients received the entire treatment as outpatients while six patients had to be hospitalized for a period of 8--14 days because of severe side effects, especially in Weeks 3--8. Serious complications such as bowel perforation were not seen, but one patient died with septicemia as a result of agranulocytosis, which was attributed to the treatment with levamisole.
 ...
PMID:Phase II study of adriamycin, 5-fluorouracil, levamisole, and irradiation in carcinoma of the bladder. 44 95

Campylobacter jejuni/coli has recently become recognized as a common bacterial cause of diarrhea. Infection can occur at any age. The usual incubation period of campylobacter enteritis is 2 to 5 days. Fever, diarrhea and abdominal pain are the most common clinical features. The stools frequently contain mucus and, a few days after the onset of symptoms, frank blood. Significant vomiting and dehydration are uncommon. A rapid presumptive laboratory diagnosis may be made during the acute phase of the illness by direct phase-contrast microscopy of stools. Isolation of the organism from stools requires culture in a selective medium containing antibiotics and incubation under reduced oxygen tension at 42 degrees C. The organism persists in the stools of untreated patients for up to 7 weeks following the onset of symptoms. Erythromycin may produce a rapid clinical and bacteriologic cure, and should be used to treat moderately to severely ill patients as well as patients with compromised host defences. The emergence of erythromycin-resistant strains requires close monitoring. The epidemiologic aspects of campylobacter enteritis will be fully understood only when methods become available for differentiating strains of C. jejuni/coli. The historical background and current knowledge of campylobacter enteritis are reviewed in this paper.
 ...
PMID:Campylobacter enteritis. 45 9

10 patients with missed abortion, intrauterine fetal death or hydatifidiform mole were given 15-(S)-15-methyl prostaglandin F2 alpha intramuscularly for the induction of labour or, in 2 cases, to obtain softening of the cervix prior to curettage. The mean time interval between induction and abortion was 6 h 9 min, with a mean dosage of 890 mcg prostaglandin per patient. Vomiting or diarrhoea occurred in 7 patients. Apart from a drop in haemoglobin concentration in 1 patient and a temporary increase in white cell count in 6 patients, no other pathological laboratory findings were detected. We conclude from these results and the relevant literature that the intramuscular administration of 15-(S)-15-methyl prostaglandin is an effective and safe means of inducing labour in missed abortion, intrauterine fetal death and hydratidiform mole.
 ...
PMID:[Administration of 15-(S)-15-methyl prostaglandins F2 alpha in intrauterine fetal death, missed abortion and hydatidiform mole (author's transl)]. 46 45

The tetracycline class of antibiotics is infrequently used in clinical pediatrics due to its side effects: they include anorexia, nausea, vomiting and diarrhea. Hypersensitivity, a photosensibility reaction and a brownish discoloration of teeth is less frequently, a pseudotumor cerebri is rarely seen. Once therapeutic plasma levels are exceeded however, either by overdosage or decreased renal or hepatic clearance of the drug, serious complications like a secondary Fanconi-Syndrom or a nephrogenic diabetes insipidus can occur. The increased toxicity of tetracyclines in pregnant women is well known. We would like to report a fatal case, where serious complications like a secondary Fanconi-Syndrom, toxic degeneration of the liver, a clinically undected pancreatitis and a protein loosing enteropathy are though to be either direct consequences of tetracycline overdosage or the indirect effect of a shocklike syndrom by means of a nonoliguric renal failure induced by tetracycline.
 ...
PMID:[Tetracyclin intoxication versus idiopathic pancreatitis: report of a case with multiple organ involvement (author's transl)]. 47 25

A new PGE2 derivative (16-phenoxy PGE2 methyl sulfonylamide sulprostone) was administered by the i.m. route to 48 women pregnancy in any of the three trimesters. The indications for pregnancy interruption were either serious medical problems in intact pregnancies (21 cases) or due to fetal death in utero (27 cases). Single doses of 500 micrograms were repeated every 4 hours in the former group or every 6 hours in the latter category for a maximum period of 24 hours. The treatment was successful in 81% of intact pregnancies and in 92.6% of fetal death cases with an overall mean induction interval of 12.9 hours. More than half the subjects did not experience any side effects apart from mild or moderate uterine colics. An overall mean of 1.4 episodes of vomiting or diarrhoea per induction trial was quite acceptable from the clinical point of view. The absence of serious complications in the group of critically sick women speaks in favor of the relative safety of the drug.
 ...
PMID:Intramuscular 16-phenoxy PGE2 ester for pregnancy termination. 47 39

Fifteen low birth weight infants had their conditions complicated by the formation of a lactobezoar. The mean gestational age was 30.3 weeks; mean birth weight was 1,184 g, and the mean age at the time of diagnosis was 11.8 days. Twelve of the infants were receiving an 80 kcal/dL-formula and one infant, a 40 kcal/dL-formula designed for the premature infant. Symptoms included abdominal distension, emesis or increased gastric residual, diarrhea, hematest-positive stools, abdominal mass, and gastric perforation.
 ...
PMID:Increased incidence of lactobezoars in low birth weight infants. 47 45

Sulprostone was administered to 628 women, 14-47 years of age, to induce abortion in cases of intact and disturbed pregnancies in the 5th - 37th weeks. The preparation was administered in 30 cases as a suppository, in 86 cases intra- or extraamnially, in 302 cases intravenously (i.v.) and in 210 cases intramuscularly (I.m.). The suppositorial administration cannot be used in induce abortion. A complete abortion was induced in 10 of 56 women in the first trimester and in 15 of 20 women in the second trimester with an extraamnial instillation of sulprostone, and in 90% by intraamnial infusion. The best results from i.v. administration of sulprostone were obtained by administering a total dosage of 1000 mcg of the drug over a 10 hour period. Incomplete or complete abortion was induced in 84.7% of the women in the first trimester who received sulprostone i.v. with an average induction-abortion interval (i.a.i.) of 12.2 hours. Complete abortion was obtained in 90% of the women in the 2nd trimester who received sulprostone i.v., with an average i.a.i. of 13.2 hours for intact and 9.3 hours for disturbed pregnancies. 30 patients less than 6 weeks pregnant received two 500 mcg i.m. injections of sulprostone to induce bleeding. 167 women in the early second trimester were given sulprostone i.m., 1-3 doses of 500 mcg at 4-8 hr. intervals. An abortion resulted in 50% of the patients after 1 injection. The rate of incomplete abortions increased with increased dosage. An average i.a.i. of 11.4 hours was recorded. In both i.v. and i.m. applications, increased dosage did not cause increased effectiveness, but increased side effects. 23.5% of the patients experienced nausea, 15.1% vomiting, and less than 1% diarrhea. I.m. administration is preferred up to the 12th week of pregnancy, while i.v. administration is preferred for disturbed pregnancies after the 12th week.
 ...
PMID:[A new therapeutic approach for terminating intact and disturbed pregnancies: three years of experience with the prostaglandin E2-derivative sulprostone (SHB 286) (author's transl)]. 47 68

A case report of subacute, reversible ischemic colitis associated with use of oral contraceptives (OCs) is reported. A 19-year-old woman was admitted to the hospital with chief complaints of abdominal cramps, nausea, vomiting, diarrhea, and rectal bleeding of 2 days' duration. Past medical history and family history were noncontributory. The patient was receiving no medication other than Norinyl 2 (2 mg of norethindrone and .1 mg of mestranol), which she had been taking for 6 months. 2 days before admission the patient had taken 100 mg of dimenhydrinate and 2 ExLax tablets (90 mg of phenolphthalein) for constipation. Colonic roentgenograms revealed impaired mesenteric circulation and bowel ischemia; OC-induced ischemic bowel disease was diagnosed. Patient symptoms subsided within 96 hours of discontinuing the OC and initiating supportive therapy (including intravenous fluid infusion, nasogastric suction, analgesics, and antiemetics). When a repeat barium enema was performed, it showed resolution of the ischemia. In a short review following the case report, these drugs were indicted in causation of colitis-like syndrome: amoxicillin, ampicillin, cephazolin, chloramphenicol, chlorpropamide, clindamycin, cloxacillin, cotrimoxasole, cyclophosphamide, digitalis, ergotamine tartrate, flucytosine, fluorouracil, gold salts, laxative and cathartic abuse, mercurous chloride, methyldopa, penicillin V, and tetracycline. Ischemic bowel disease secondary to OC use is a rare but important complication because of its significant morbidity and potential mortality, and because of the widespread use of the drugs. The case report emphasizes the need to consider the differential diagnosis of acute vascular insult with bowel ischemia when acute abdominal pain progressing to bloody diarrhea occurs in young women taking OCs.
 ...
PMID:Oral contraceptive-induced ischemic bowel disease. 48 72

This article discusses the parallel results of interruption of advanced pregnancy (14-20 weeks) with Prostaglandin F2alpha (PGF2alpha) and a 20% NaCl solution. 40 mg of PGF2a was administered intraamniotically with another 20 mg administered if abortion did not occur within 24 hours. The 20% NaCl solution was given intraamniotically and without aspiration of the fetal liquid in a quantity of 200 ml in some of the patients. Likewise, with the 20% NaCl solution, an intravenous (IV) infusion of syntocyne was administered drop by drop (average dosage 0.19 Ij/minute). This procedure was carried out until abortion of the fetus took place in 1/2 of the patients, while in the second 1/2 it was performed until abortion of the placenta. The abortion was considered a failure it it did not take place within 48 hours (with administration of both agents). In 67 cases, abortion was successful with PGF2alpha. In 4 patients it failed and was terminated by induction with syntocyne. However the 20% NaCl solution and IV syntocyne infusion resulted in abortion in 71 patients. The following number of incomplete abortions was registered: 20.9% with PGF2alpha and 16.9% with hypertonic NaCl solution. The latency period was 22.21 hours with PGF2alpha and 21 hours with 20% NaCl solution. Side effects (vomiting, diarrhea, fever) were higher with the PGF2alpha. 2 cases of diffuse peritonitis were registered, each due to each one of the agents, and both patients recovered. Better results with the 20% NaCl were due to the parallel IV infusion of syntocyne. However, caution must be exercised as this utertonic may cause genital organ lesions.
 ...
PMID:[Comparison of the results of interruption of advanced pregnancy using prostaglandin F2-alpha and a NaCl solution]. 50 72

Accidental acute mercury vapor poisoning in three persons is reported. Three hours after exposure, symptomatology began by chills, vomiting, diarrhea and chest pain. Two patients, respectively 67 and 77 year old, presented severe pulmonary edema, then neurological symptoms with tremor and coma. This toxic pulmonary edema, which entailed artificial ventilation, was followed in both cases by an acute interstitial pulmonary fibrosis which led to death respectively after six and sixteen days. In the third case (a thirty eight year old patient) a skin rash, erythematous and pustuliform was observed. Analysis for total mercury by flameless atomic absorption showed very high mercury levels in blood and urine of the three patients. The effect of treatment by Dimercaptopropanol on renal excretion of mercury was studied. Optic and electron microscopy of the lung of the two patients who died showed the pulmonary changes of acute interstitial fibrosis.
 ...
PMID:Accidental acute mercury vapor poisoning. 50 88


<< Previous 1 2 3 4 5 6 7 8 9 10