Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During a 4-year period a 28-year-old female had 4 episodes of eosinophilia of over 10,000/mu 1; these episodes were associated with nausea, vomiting, diarrhea, and abdominal pain. On one occasion, she had ascites and pleural effusion which contained numerous mature eosinophils. On each occasion, these attacks disappeared within several weeks without any specific treatment. A diagnosis of eosinophilic gastroenteritis was made. A plasma sample obtained during the eosinophilia generated in vitro eosinophilic colonies when added to granulocyte/macrophage-progenitor (CFU-GM) cultures without exogenous growth factors. Colony formation was inhibited by anti-interleukin-5 (IL-5) antibody but not by antibodies toward IL-3, granulocyte colony-stimulating factor (G-CSF) or GM-CSF. A high plasma interleukin-5 (IL-5) level was noted when measured by enzyme-linked immunosorbent assay, while IL-3, G-CSF, and GM-CSF were undetectable. During remission the plasma gave negative results both for colony formation and IL-5 level. These results indicate that the eosinophilia of this disease is mediated by IL-5.
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PMID:Interleukin-5 in eosinophilic gastroenteritis. 138 Feb 4

We review the Spanish literature on Eosinophilic Gastroenteritis. The data are compared with those of several foreign series. Abdominal pain, vomiting, diarrhea, and abdominal distension due to ascites were the most frequent clinical manifestations. In our country most cases had ascites. A history of allergy was reported by less than on half of patients. Peripheral eosinophilia with otherwise normal laboratory findings is the rule. However, peripheral eosinophilia was not essential for diagnosis, since it was absent in one quarter of patients. Small intestine barium studies were abnormal almost always, but the findings were not specific. The diagnosis is based on the endoscopic and/or peroral gastrointestinal biopsy. However, a false negative diagnosis can occur, since the disease can take up a patchy distribution, or a more profound involvement of the gastrointestinal layers without mucosal disease. The treatment of choice is corticosteroids, with a spectacular therapeutic response. Complete studies with biopsies taken at multiple levels of the gastrointestinal tract, are necessary to ascertain the extent and depth of the disease. The etiology is unknown, and although allergy causes can be elicited in some cases, they are absent in the majority of them. We encounter no essential differences in the eosinophilic gastroenteritis characteristics in our country in relation to other countries.
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PMID:[Eosinophilic gastroenteritis: review of the published cases in Spain and comparison with foreign literature]. 763 83

Two patients suffering from eosinophilic gastroenteritis (EG) were treated with sodium cromoglycate (SCG). Before treatment they showed enteric and cutaneous symptoms, such as abdominal pain, nausea, vomiting, diarrhoea and recurrent urticaria and angioedema. The histological findings were a notable amount of eosinophilic infiltration in the lamina propria and gastric glands, a villous shortening and thickening and weak eosinophilic inflammation in the duodenum. The patients were treated with 300 mg SCG, 4 times daily, for 4/5 months. During treatment, the clinical symptoms disappeared and at the end of treatment a reduced inflammation with an almost complete decrease of eosinophilic infiltration was observed. The results provide evidence of SCG efficacy in the treatment of EG and suggest its employment as an alternative to the steroids commonly used in EG.
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PMID:Sodium cromoglycate in the treatment of eosinophilic gastroenteritis. 210 47

A young female with two episodes of obstructive jaundice and frequent postprandial vomiting over a 2-month period was found to have marked narrowing with irregularity of the mucosa of the descending duodenum and dense eosinophilic infiltration of the muscular and serosal layers. This unusual presentation illustrates the wide variety of gastrointestinal manifestations of eosinophilic gastroenteritis.
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PMID:Eosinophilic gastroenteritis presenting with biliary and partial duodenal obstruction. 237 11

Eosinophilic gastroenteritis (EG) is an uncommon disorder, characterised by cramping abdominal pain, diarrhoea and vomiting and histologically by eosinophilic infiltration of bowel wall. We present a patient who developed EG during the course of a systemic, necrotising vasculitis, who became critically ill after failure of treatment with corticosteroids and cytotoxic drugs and responded only to oral sodium chromoglycate.
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PMID:Near fatal eosinophilic gastroenteritis responding to oral sodium chromoglycate. 314 28

A 49-year-old patient presented with urticaria, vomiting, diarrhea and peripheral eosinophilia. A histological diagnosis of eosinophilic gastroenteritis was made. Within 3 weeks of admission a highly papillary adenocarcinoma of the right ovary was diagnosed. The gastrointestinal symptoms and the eosinophilia disappeared after partial resection of the tumor and chemotherapy. A possible relationship between cancer, eosinophilia and eosinophilic gastroenteritis is discussed.
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PMID:Malignant tumor masquerading as eosinophilic gastroenteritis. 362 86

We report two children with eosinophilic gastroenteritis--a 14 month old atopic boy with persistent vomiting and aspiration pneumonitis illustrates the mucosal variety of the disorder, and a 9 year old boy with eosinophilic ascites typifies serosal involvement.
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PMID:Eosinophilic gastroenteritis. 409 87

Eosinophilic gastroenteritis is a diagnosis to be entertained whenever a patient had abdominal complaints accompanied by striking peripheral eosinophilia. A definitive diagnosis is of greater importance in this illness, since undiagnosed cases often undergo needless exploratory surgery. An infant seen at 2 years, 10 months of age with abdominal pain, nausea, and vomiting was found to have a white blood cell count of 50,000/cu mm with 54% eosinophils and eosinophilic ascites. An antral tissue biopsy yielded a diagnosis of eosinophilic gastroenteritis after many studies had been made to exclude other diagnoses. Treatment with intermittent courses of prednisone kept the patient relatively asymptomatic over the period of 20 years during which she remained under our care. Immunologic studies shed no light on the etiology of this patient's disorder. The literature dealing with diffuse, infiltrative eosinophilic gastroenteritis is reviewed.
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PMID:Eosinophilic gastroenteritis in the pediatric patient. 714 Jan 22

We performed a clinical and pathological study of a 5 year old female mongrel dog (Drahthaar) with eosinophilic gastroenteritis. The animal was presented with vomiting and was reported to have had bloody diarrhoea for 4 months. The lesions were in atypical locations: in the fundus of the stomach, the ileocaecal valve and the rectum, near the anal sphincter. The lesions in the stomach wall were particularly severe and included severe fibroplasia, especially in the muscle layer and submucosa. Fibroplasia was less visible in the other locations. The presence of eosinophilic granulomatous masses led us to suspect a possible parasitic infection, although some authors note that this pathological condition may have an allergic aetiology.
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PMID:Eosinophilic gastroenteritis syndrome in a dog. 761 May 55

Eosinophilic gastroenteritis (EGE) is a rare condition of unknown cause characterized by peripheral eosinophilia, eosinophilic infiltration of the gastrointestinal tract, and gastrointestinal symptomatology. EGE is generally classified according to the layer of gastrointestinal tract involved. Mucosal involvement, the most common form of presentation, may result in abdominal pain, nausea, vomiting, diarrhea, anemia, and protein-losing enteropathy. Patients with muscular layer disease generally have gastrointestinal obstruction. Serosal eosinophilic infiltration, the rarest form of presentation, may result in development of eosinophilic ascites. EGE complicated by ascites can be effectively treated with steroids after other systemic disorders associated with peripheral eosinophilia have been ruled out.
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PMID:Eosinophilic gastroenteritis manifesting with ascites. 809 Dec 67


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