Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because preoperative cervical dilatation is advantageous, especially in nulliparous subjects, dilatation before vacuum aspiration was achieved by a single intramuscular dose of 500 mcg of 16 phenoxy delta 17,18,19,20 tetranor prostaglandin (PG) E2 methyl sulfonylamide. 80 first trimester nulliparas, aged 15-34, were pretreated 3 hours before uterine evacuation with the PG analog. None of the 80 aborted during the interval between PG injection and uterine evacuation, but 25 (31%) had some uterine bleeding. In 24 of these 25, bleeding was slight ( 10 ml), and it was moderate in the other (25-50 ml). 3 hours after PG administration, the degree of cervical dilatation ranged from 4-14 mm. 60 patients (75%) achieved adequate dilatation (8 mm or more), allowing for complete uterine evacuation without mechanical dilatation. 17 patients whose cervices had dilated 6-7 mm had slight further dilatation which was easily performed. The cervix failed to dilate beyond 4 mm in 3 subjects, and mechanical dilatation proved difficult. Uterine pain was reported by all subjects. Complications (through 4-weeks follow-up) were not evident. Side effects were those common to PG, i.e., vomiting, transient pyrexia 1 degree centigrade, and pain requiring analgesia. The time interval between PG injection and adequate cervical dilatation was short enough to avoid overnight hospitalization and seems an efficacious outpatient procedure.
 ...
PMID:Intramuscular administration of 16 phenoxy omega 17,18,19,20 tetranor PGE2 methyl sulfonylamide for pre-operative cervical dilatation in first trimester nulliparae. 71 49