Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Use of 16-phenoxy-prostaglandin E2 methane sulfonamide (SH B 286), a prostaglandin E2 derivative, as an abortifacient in 114 patients is reported. Vital signs, intrauterine pressure, and blood levels of steroid hormones, chorionic gonadotropin, and placental lactogen were noted before, during, and after administration. Extraamniotic injection of 100-250 mcg induced abortion in 80% of the 76 women observed. No severe systemic effects occurred, and vomiting (15%), nausea (25%), and uterine cramps (40%) rarely required treatment. Of 38 women receiving an intravenous drip, complete abortion was induced in 33; side effects were dose-dependent and no severe complications were seen. The lowest dose (0.5-1.5 mcg/ml, 1000 mcg total dose) was as effective as larger doses. Uterine contractions were increased by the medication, while serum hormone levels, especially progesterone, decreased. SH B 286 is shown by this study to be an effective and safe abortifacient. (Author's)
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PMID:[First results with a new prostaglandin E2-derivate (author's transl)]. 60 50

Starvation ketosis outside pregnancy is rare and infrequently causes a severe acidosis. Placental production of hormones, including glucagon and human placental lactogen, leads to the insulin resistance that is seen in pregnancy, which in turn increases susceptibility to ketosis particularly in the third trimester. Starvation ketoacidosis in pregnancy has been reported and is usually precipitated by a period of severe vomiting. Ketoacidosis is likely to have important implications for fetal survival as ketoacidosis in women with type 1 diabetes mellitus is associated with intrauterine death. This article features four cases of women with vomiting in the third trimester of pregnancy associated with a severe metabolic acidosis. The mechanism underlying ketogenesis, the evidence for accelerated ketogenesis in pregnancy and other similar published cases are reviewed. A proposed strategy for management of these women is presented.
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PMID:Starvation ketoacidosis in pregnancy. 2313 45