Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042963 (
vomiting
)
31,883
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Migraine is a disorder characterized by attacks of monolateral headaches, often accompanied by nausea,
vomiting
, and photophobia. Around 30% of patients also report aura symptoms. The cause of the aura is believed to be related to the cortical spreading depression (CSD), a wave of neuronal and glial depolarization originating in the occipital cortex, followed by temporary neuronal silencing. During a migraine attack, increased expression of inflammatory mediators, along with a decrease in the expression of anti-inflammatory genes, have been observed. The aim of this study was to evaluate the expression of inflammatory genes, in particular that of IL-1 receptor antagonist
(IL-1RN)
, following CSD in a mouse model of familial
hemiplegic migraine
type 1 (FHM-1). We show here that the expression of
IL-1RN
was upregulated after the CSD, suggesting a possible attempt to modulate the inflammatory response. This study allows researchers to better understand the development of the disease and aids in the search for new therapeutic strategies in migraine.
...
PMID:Upregulation of IL-1 Receptor Antagonist in a Mouse Model of Migraine. 3133 Nov 9
Objectives:
Vestibular migraine (VM) is a common vestibular disorder, and familial aggregation of VM with autosomal-dominant inheritance has been described, which supports a genetic background. This study aimed to describe the clinical phenotype of a family with VM, and identify a candidate gene for VM.
Methods:
We recruited six individuals (four affected and two unaffected) from three consecutive generations of a Korean family with VM, and performed whole-exome sequencing to search for candidate genes.
Results:
All affected individuals presented with recurrent vertigo, headache, and nausea/
vomiting
that fulfilled the diagnostic criteria of VM. Two individuals also experienced transient hemiparesis or dysarthria during the episodes. The symptoms were triggered by physical or emotional stress. Interictal examinations showed uni- or bi-directional horizontal gaze-evoked nystagmus in three of the individuals. They had no causative mutations in genes causing familial
hemiplegic migraine
or episodic ataxia. Through whole-exome sequencing from three affected individuals, we identified a nonsense mutation c.3526C>T in
TRPM7
that encodes a cation channel selective to Ca
2+
and Mg
2+
.
Conclusions:
Alterations in intracellular Ca
2+
and Mg
2+
homeostasis by
TRPM7
mutation may contribute to the development of the VM phenotype. Our result suggest that
TRPM7
is a novel candidate gene for VM.
...
PMID:
TRPM7
as a Candidate Gene for Vestibular Migraine. 3319 64
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