Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We explored the question of whether amphibians get motion sickness by exposing anurans (frogs) and urodeles (salamanders) to the provocative stimulus of parabolic aircraft flight. Animals were fed before flight, and the presence of vomitus in their containers after flight was used to indicate motion-induced emesis. None of the species that we studied vomited during the 8 to 10 parabolas of each flight. However, at least one specimen from each of the anuran species Rana rugosa, Rana nigromaculata, Hyla japonica, and Rhacophorus schlegelii vomited in a period of 0.5 to 42 h after flight. Some specimens of R. nigromaculata, H. japonica, and R. schlegelii were also observed retching without emesis either during or shortly after exposure to parabolic flight. We were unable to induce either emesis or retching behavior in the aquatic from Xenopus laevis. Among the urodeles studied we saw no signs of motion sickness in either adult or larval Cynops pyrrhogaster, but at least one larval Hynobius nebulosus vomited shortly after parabolic flight. The amphibian species that exhibited the most motion sickness were the same ones that showed the greatest amount of tumbling during the microgravity phases of their parabolic flights. The most distinctive difference between motion sickness in amphibians and mammals that vomit, including man, is the long delay between a provocative stimulus and emesis proper in the amphibians. The retching behavior we induced in the frogs was identical to that described previously for frogs treated with emetic drugs. H. japonica, exposed to extended periods of microgravity on the MIR Space Station, flattened their bellies against the substrate and dorsiflexed their heads in a manner reminiscent of drug-induced nausea. In light of our current observations of retching behavior in motion sick H. japonica, we suggest that the previously observed behavior of three frogs on the MIR Space Station was a manifestation of motion sickness.
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PMID:Motion sickness in amphibians. 821 58

Ten subjects participated in a laboratory experiment using cross-coupled angular stimulation to induce motion sickness symptoms. A 14-channel montage using subdermal electrodes was employed to record the electroencephalogram during a pre-Coriolis stimulation baseline through to imminent emesis. Spectral analyses of the EEG were performed upon the recorded data and individual band energies were quantified to attempt to characterize the cortical electrical response to motion sickness. Power spectral analysis was performed upon the temporo-frontal signals through the entire period over the delta, theta, and alpha EEG bands. The power in each of these bands was integrated and the baseline periods compared with that during frank sickness. Mean power spectral energy in the delta band during frank sickness increased by a factor of 13.7 over baseline. Mean theta band energy increased by a factor of 2.2. Mean alpha band energy was not significantly different. EEG power spectral levels in the delta and theta bands increased along with the level of motion sickness symptoms. These changes, particularly those in the delta band, suggest that intense low frequency oscillatory stimulation is being diffusely projected about the central nervous system. These EEG changes, similar to those sometimes seen in partial seizures, and the similarity of the symptom/sign complex in the two disorders, provide evidence that the pathophysiology and electrophysiology of motion sickness may be a variant of seizure activity.
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PMID:Spectral analysis of the electroencephalographic response to motion sickness. 842 36

One hundred and forty-seven patients undergoing minor orthopaedic surgery were studied prospectively by logistic regression analysis to determine the association of independent fixed patient factors with the incidence of postoperative sickness (nausea, retching or vomiting). Gender, history of previous postoperative sickness, postoperative opioids and interaction between gender and previous history of sickness were significant independent factors for postoperative sickness; history of motion sickness was weakly associated. The probability of postoperative sickness in the first 24 h after surgery may be estimated from the equation: logit postoperative sickness = -5.03+2.24(postoperative opioids) +3.97 (previous sickness history) +2.4 (gender) +0.78 (motion sickness) -3.2 (gender x previous sickness history). (Log likelihood ratio test for 5 degrees of freedom for the coefficients, chi-square = 53.5 (P < 0.001).) It is suggested that the calculated probability for sickness may be a useful addition for balancing patient treatment groups and allowing between-study comparisons.
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PMID:Logistic regression analysis of fixed patient factors for postoperative sickness: a model for risk assessment. 843 54

Histamine H1-receptors are involved in the development of the symptoms and signs of motion sickness, including emesis. On provocative motion stimulus, a signal for sensory conflict activates the histaminergic neuron system, and the histaminergic descending impulse stimulates H1-receptors in the emetic center of the brain stem. The histaminergic input to the emetic center through H1-receptors is independent of dopamine D2-receptors in the chemoreceptor trigger zone and serotonin 5HT3-receptors in the visceral afferent, which are also involved in the emetic reflex. Antihistamines block emetic H1-receptors to prevent motion sickness. Acetylcholine muscarinic receptors are involved in the generation of signals for sensory conflict. Anti-cholinergic drugs prevent motion sickness by modifying the neural store to facilitate the acquisition of habituation to provocative motion.
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PMID:Neuropharmacology of motion sickness and emesis. A review. 844 18

Royal Made Ping An Dan (PAD) is a royal clandestine prescription of the Qing Dynasty Imperial hospital for emperors, empresses, ministers, imperial maids and eunuchs. Experimental study confirmed; (1) PAD had apparent peripheral effect in inhibiting vomiting and improving mental state (P < 0.05). (2) PAD possessed markedly sedative effect (P < 0.05). (3) PAD was able to strengthen the defence ability of gastric mucosa and decreased its damage induced by chemical irritation. (4) PAD could markedly relieve the spasm of intestinal smooth muscle in vitro. (5) PAD could inhibit the growth of common pathogenic bacteria in intestine and stomach such as B. coli and B. dysenteriae. (6) The study of toxicology suggested that PAD was safe for clinical use. The clinical results showed that PAD possessed the effect in preventing 274 persons on motion sickness. The total effective rate of PAD group was 83.9%, while that of Dramamine group was 60.8%. PAD revealed better effect than that of Dramamine. Therefore, the authors realize that PAD is a better preventive drug for motion sickness.
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PMID:[Clinical and experimental studies on royal made ping an dan in preventing motion sickness]. 849 29

We studied the prevalence and the characteristic features of cyclical vomiting syndrome (CVS) in the defined childhood population of the City of Aberdeen, in Scotland. Initial screening was done by questionnaire in 10% of all children between 5 and 15 years of age (2,165 children) attending schools in Aberdeen, followed by clinical interviews of symptomatic children. We invited for clinical interview 69 children (3.9%) with a history of unexplained vomiting; 46 (67%) attended. Of them, 34 fulfilled the criteria for the diagnosis of CVS (prevalence rate, 1.9%). Children with CVS had a mean age of 9.6 years and a mean age at onset of symptoms of 5.3 years (range, 1-13). The overall sex ratio was 1:1, although in younger children boys were more commonly affected than girls. Seven children (21%) also suffered from migraine, 10 (29%) from travel sickness, and 10 (29%) from atopic diseases. The attacks of vomiting occurred on average eight times per year, with a mean duration of 20 h. Travel was a frequent precipitating factor. Attacks were commonly associated with pallor, anorexia, and malaise and were often relieved by rest and sleep. The clinical features of CVS overlapped to a large extent with those of migraine, suggesting a common pathogenesis. Features common to both conditions included trigger factors, associated GI, sensory, and vasomotor symptoms, and factors that relieved attacks. There was also an association between CVS and headache, abdominal pain, atopic diseases, and travel sickness.
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PMID:Cyclical vomiting syndrome in children: a population-based study. 858 99

The efficacy of transdermal hyoscine in the reduction of nausea, retching and vomiting was compared with placebo during and after stapedo- and tympanoplasty under local anaesthesia in a double-blind, prospective and randomized study. In the placebo group (n = 29), 69% of the patients were free from emetic symptoms during and 41% after the operation. The corresponding figures were 93% (P < 0.05) and 74% (P < 0.05) in the hyoscine group (n = 27). The patients in the placebo group needed more droperidol during and after operation (P < 0.05). The frequency of side effects was similar in both groups. In posturography the patients with emetic sequelae in the placebo group had a markedly deteriorated upkeep of posture (P < 0.05) measured as body sway velocities. A strong correlation was found between motion sickness and emetic sequelae after surgery, and patients with a history of motion sickness benefited most from hyoscine.
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PMID:Effect of transdermal hyoscine on nausea and vomiting during and after middle ear surgery under local anaesthesia. 868 87

The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, post-operative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.
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PMID:Towards understanding the aetiology and pathophysiology of the emetic reflex: novel approaches to antiemetic drugs. 869 45

The cardinal symptoms of motion sickness occur in the gastrointestinal system. This study sought to investigate the influence of sickness-provoking motion stimuli on the interdigestive migrating electric complex (IDMEC) of the gastro-intestinal system. Thirteen susceptibles and 14 insusceptibles to motion sickness were subjected to intralumenal recording before and after caloric vestibular stimulations. Motion sickness developed in all subjects. The results indicate that there are no significant differences in the IDMECs of susceptibles and insusceptibles in a state of rest; vestibular stimulation changes the duration of IDMEC phases (P < 0.05 and P < 0.01); IDMEC changes differ slightly between susceptibles and insusceptibles; motion stimuli induce simultaneous nonpropulsive spike activity, which is more frequent in susceptibles (P < 0.01); vestibular stimulation applied during phase III of IDMEC does not provoke vomiting in susceptibles.
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PMID:Changes in the gastrointestinal electric pattern to motion sickness in susceptibles and insusceptibles during fasting. 871 5

We examined the effects of caloric stimulation on the neuronal activity of the locus coeruleus (LC) and of the vestibular nucleus complex (VNC) in urethan-anesthetized rats. The single unit activity of neurons in the LC and VNC was extracellularly recorded. A polyethylene tube for caloric stimulation was inserted into the middle ear cavity on the ipsilateral side. Through the tube, the middle ear was irrigated by hot (44 degrees C), cold (30 degrees C), and ice (4 degrees C) water. The majority of neurons in the VNC showed excitation by middle ear irrigation with hot water and inhibition by ice-water irrigation. The responses occurred during caloric stimulation and disappeared immediately after the cessation of the stimulation. The results suggest that the responses of VNC neurons to caloric stimulation directly reflect changes in primary vestibular afferent activity. On the other hand, the predominant effect of caloric stimulation with hot and cold water on LC neuronal activity was inhibitory. The suppression of LC neuronal activity occurred approximately 1 min after the cessation of the caloric stimulation and persisted for 3-5 min. The results suggest that LC neurons receive processed vestibular signals. Motion sickness and vestibular dysfunction induced by caloric stimulation cause emesis, which is known as vestibulo-autonomic response. The vestibulo-autonomic syndrome can be prevented by amphetamine, a noradrenaline releaser. Therefore, the inhibitory response of noradrenergic LC neurons to vestibular stimulation may be involved in the vestibulo-autonomic response.
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PMID:Responses of locus coeruleus neurons to caloric stimulation in rats. 874 93


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