Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dizziness with illusionary rotatory or pendular sensations and dysequilibrium accompanied by nausea and occasionally by vomiting may appear during down-hill skiing. It is proposed that the condition is called "ski sickness". Ski sickness seems to represent a special form of motion sickness produced by unusual and contradictory sensory information between the visual, vestibular and somato-sensory system. The pathophysiology seems to be related to vestibular overstimulation from winding turns on uneven ground, insufficient visual control, specially on foggy days with reduced visibility (on so called "white days"), often in connection with minor ophthalmologic problems such as myopia or astigmatism and altered somato-sensory input due to the wearing of ski boots and skis. Psychological factors such as fear of heights, fear of mountains, high speed and falling may contribute as well as the atmospheric pressure changes in the ear when descending rapidly from high to low altitude. The symptoms of ski sickness can be relieved by vestibular suppressants. The present report indicates various characteristics of a series of 11 persons suffering from ski sickness.
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PMID:Ski sickness. 776 76

1. The effects of (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOl), a 5-hydroxytryptamine 5-HT2A/5-HT2C receptor agonist, on motion- and cisplatin-induced emesis were studied in Suncus murinus. Subcutaneous injection of DOl, 30 min prior to the emetic stimuli, dose-dependently blocked the emesis induced by motion sickness and cisplatin (20 mg kg-1, i.p.) with estimated ID50 values of 640 and 780 micrograms kg-1, respectively. 2. alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT), a peripheral 5-HT2A/5-HT2C receptor agonist, had no effect on motion- and cisplatin-induced emesis. 3. The antiemetic effects of DOl on motion- and cisplatin-induced emesis were attenuated by preadministration of ketanserin, a selective 5-HT2A receptor antagonist. 4. The present results suggest an inhibitory role for central 5-HT2 receptors in the emetic reflex mechanism and that a 5-HT2 receptor agonist may be a useful tool to investigate the involvement of 5-HT receptors in the emetic reflex.
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PMID:Blockade of motion- and cisplatin-induced emesis by a 5-HT2 receptor agonist in Suncus murinus. 778 Jun 47

An alternative hypothesis to that provided by conflict theory is formulated to account for motion sickness. The new approach is predicted on the oculocardiac reflex (i.e., bradycardia produced by extra-ocular muscle traction) (18) and empirical evidence that retrobulbar anesthesia significantly lowers the incidence of emesis after strabismus surgery (14). Eye muscle traction is presumed to elicit afferent signals that ultimately stimulate the vagus nerve (15). The same neuromotor sequence is presumed to occur during reflexive eye movements under vestibular control and during more complicated combinations of reflexive and voluntary eye movements. It is proposed that the blocking of afferent signals from extra-ocular muscle in an otherwise intact vestibulo-ocular system will eliminate the signs and symptoms of motion sickness normally produced in a provocative environment.
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PMID:The possible role of nystagmus in motion sickness: a hypothesis. 784 Jul 43

We have investigated 195 pre-menopausal women undergoing third molar extractions, in a prospective study, to assess the influence of the day of the menstrual cycle on the incidence of postoperative nausea or vomiting. In the 95 patients taking the oral contraceptive pill the incidence of postoperative nausea or vomiting was higher on days 9 to 15 of the menstrual cycle (P < 0.05) than on days one to eight and days 16 to the end of cycle. In the 100 patients who were not taking the oral contraceptive pill the incidence of postoperative nausea or vomiting was not higher on days 9 to 15. The strongest predictor for postoperative nausea or vomiting in our study was a previous episode of postoperative nausea or vomiting (P < 0.005). Patients with a tendency to motion sickness did not have a higher incidence of postoperative nausea or vomiting.
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PMID:The menstrual cycle and nausea or vomiting after wisdom teeth extraction. 795 96

The antiemetic effects of flesinoxan were evaluated following s.c. administration in cats. Flesinoxan produced a dose-dependent suppression of motion sickness and also reduced xylazine-induced emesis at higher doses. Flesinoxan had a short latency to onset and may have a brief duration of action. It was slightly more potent that 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), in contrast to their relative potencies on most other in vivo measures. High doses of both agonists produced defensive behavior as a result of 5-HT1A receptor stimulation. (-)-Propranolol, which previously reduced 8-OH-DPAT suppression of feline motion sickness, failed to reduce the antiemetic effect of flesinoxan. The dose of 3 mg/kg of NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine) produced a slight decrease in motion sickness and added to the suppression of motion sickness by low doses of flesinoxan via an uncertain mechanism. It also reduced the antiemetic effect of higher doses of flesinoxan. In contrast, NAN-190 produced additive antiemetic effects when combined with 8-OH-DPAT and little if any reduction. NAN-190 reduced the defensiveness produced by both flesinoxan and 8-OH-DPAT. Phentolamine and sulpiride reduced neither the antiemetic effect nor the defensive behavior produced by flesinoxan, thus ruling out a role for alpha-adrenoceptors and dopamine D2 receptors. Flesinoxan exerted a broad spectrum antiemetic effect by an action at 5-HT1A receptors as does 8-OH-DPAT, but differed in its response to putative 5-HT1A receptor antagonists.
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PMID:Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. 801 49

The antiemetic effects of six serotonergic 5-HT1A-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-OH-DPAT), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus. Subcutaneous injection of all six agonists completely and dose-dependently suppressed motion-induced emesis. Pretreatment with 8-OH-DPAT or SUN8399 dose-dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). These results suggest that serotonergic 5-HT1A-receptor agonists are effective as anti-motion sickness drugs, and these drugs may block a common mechanism(s) for the emetic reflex of the suncus because the antiemetic effects of the 5-HT1A-receptor agonists were exerted irrespective of the stimulus.
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PMID:Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus. 802 27

This review will address issues of effects of space flights on the body. Cardiovascular deconditioning often induce symptoms like orthostatic intolerance after flight, and during flight there will be space motion sickness during the first few days with headache, malaise, nausea and eventually vomiting. These symptoms disappear and do not interfere with the performance of the astronauts after several days. During long-term flights, effects will be muscle atrophy and calcium loss from the skeleton. Radiation effects will be a significant issue, increasing with the length of the space flight. Also during long-term flights, psychological problems will become of increasing importance. Astronaut health care will be discussed related to Space Shuttle missions and Space Station missions. Furthermore, countermeasures for long-term space flights (up to 6 months) will be outlined. The NASA health care programme is reviewed, and the frequency of illnesses and injuries encountered in the NASA programme is discussed. There will be a need for setting up an international health care programme in view of the upcoming international cooperation in the Space Station era. It is emphasized that the Space Station is an international platform. Therefore, the health care team will be composed of international personnel, mainly from NASA with participation of Europe, Canada, Russia, and Japan. Specialized medical doctors will form the team and support the crew members from the ground. Some issues, such as medical licensing and responsibility, remain to be solved.
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PMID:Issues of health care under weightlessness. 804 31

The vestibular, cerebellar, and reticular systems are central in importance, in motion sickness and habituation, to the effects of motion. Nuclear medicine single photon emission computed tomography (SPECT) studies of cerebral blood flow and power spectral electroencephalographic recordings during motion sickness were used to determine alterations in the central nervous system. The rotating chair with and without visual stimulation was used to study the rate of habituation and the effect of antimotion sickness medications on this rate. An increase of theta waves over the frontal cortex indicated a decreased activation of the higher centers during motion sickness. Motion sickness also produces an increase of blood flow in the central cerebellum that has connections to the reticular system. This increase in cerebellar activity is relayed to the reticular system whereby neural recruitment builds up to trigger the vomiting center, producing motion sickness. Habituation may be a conditioned compensatory activation of the reticular neurons that prevents this disruption of normal activation. The rate of habituation when motion sickness was prevented by scopolamine was slowed, indicating that, if the central nervous system is not challenged by disruption of normal activation, it does not produce the compensatory reactions that result in habituation.
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PMID:Habituation and motion sickness. 808 94

There is abundant evidence implicating the role of arginine vasopressin in motion sickness. The effects of AVP analogs on motion sickness were investigated in squirrel monkeys. Two specific V1 antagonists (SK&F 100273 and SK&F 103561) and three mixed V1/V2 antagonists (SK&F 101926, SK&F 105494, and SK&F 104146-D) were tested on six highly susceptible monkeys. Intravenous injections of 200 ug of a V1 antagonist abolished emesis in all six monkeys, and few prodromal symptoms remained (latency to emesis > 120 minutes, P < .001). Mixed V1/V2 antagonists failed to abolish emesis in all monkeys. However, there was a slight increase in the latency to the first bout of emesis/retching with the mixed antagonists when compared with the baseline. The dose-response relationship and rate of onset of action of the V1 antagonists (SK&F 100273) were explored. Latency to the first bout of emesis/retching increased to about twice that of the baseline when half of the effective antiemetic dose was used. The efficacy demonstrated by the specific V1 antagonists indicates that V1 receptors may modulate emesis.
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PMID:Etiologic significance of arginine vasopressin in motion sickness. 808 98

Although the aetiology of postoperative nausea and vomiting is not completely clear, a number of key contributing factors increase the risk for an individual patient. The inhalational agents are variably associated with postoperative nausea and vomiting, and nitrous oxide is particularly emetogenic. Older inhalational anaesthetics, such as cyclopropane, are associated with a high incidence, while the currently used agents, isoflurane, enflurane and halothane, cause less, but still significant postoperative nausea and vomiting. Intravenous anaesthetics are also associated with differing degrees of emesis, though the newer agent, propofol, may be less emetogenic than the older anaesthetics. Opioids, used extensively throughout surgery, are further strong emetogens. Patient factors are also important--postoperative nausea and vomiting is three times more prevalent in adult females than in males, and children are around twice as susceptible as adults. Furthermore, a previous history of postoperative nausea and vomiting or motion sickness is a known risk factor. Superimposed on this is the type of surgery--abdominal and gynaecological surgery are particularly emetogenic, and the incidence of postoperative nausea and vomiting following strabismus surgery is high. Increased quality of healthcare, and a growing awareness of the importance of patient satisfaction, are providing new incentives to ensure that postoperative nausea and vomiting is dealt with adequately.
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PMID:Risk factors for postoperative nausea and vomiting. 812 61


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