Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The fact that humans and some mammals vomit when suffering from any kind of motion sickness is explained on a phylogenetic basis. The swim bladder of fish develops from the same embryological origin as the stomach. In a certain group of fish the swim bladder changes its pressure and volume by contraction during sudden upward and downward movements. As the swim bladder is in very close connection with the labyrinth in many fish, it seems absolutely possible that such contraction is caused by a labyrinthine reflex influencing the N, vagus. The contraction of the muscular wall of the stomach in humans--resulting in vomiting--is, therefore, a phylogenetic heritage.
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PMID:[The cause of vomiting in seasickness]. 662 Dec 17

Subcutaneous injections of naloxone in a total dose of 0.4 mg or greater one hour before a swing stimulus increased the frequency of motion sickness symptoms and shortened the latency of retching and vomiting.
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PMID:Systemic naloxone increases the incidence of motion sickness in the cat. 664 17

If a foot were surgically removed and it was observed that walking was then impaired, it could be concluded that the foot is part of the normal mechanism for walking and that one of the physiological functions of the foot is to facilitate walking. In seven dogs, the vestibular apparatus of the inner ear was surgically removed and it was observed that the emetic response to certain poisons was impaired. It was concluded that the inner ear is part of the normal mechanism for vomiting in response to poisons, and that one of the physiological functions of the inner ear is to facilitate the emetic response to poisons. It seems likely that the mechanism, whereby the vestibular apparatus facilitates the emetic response to poisons, is the basis of motion sickness. In essence, motion sickness can be considered the result of activation, by motion, of a mechanism that normally functions to facilitate vomiting in response to poisons.
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PMID:Another function of the inner ear: facilitation of the emetic response to poisons. 684 55

This paper analyzes motion sickness data that has been obtained from experiments involving the Office of Naval Research motion generator. Based on the analysis, a mixture of two statistical populations has been postulated as an overall model of time to first emesis. Empirical evidence indicates that the subpopulation corresponding to early emesis is Weibull.
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PMID:A statistical analysis of motion sickness incidence data. 684 62

Both epidemiological and pharmacoclinical research have been carried out on children suffering from headache. Two epidemiological trials were performed. In the first, 562 migrainous children were questioned about several clinical symptoms that affect child headache suffers, and the incidence of these symptoms was recorded. In the second, we divided 504 nonselected school children into three groups: headache sufferers and nonheadache sufferers with or without family headache history. The same clinical symptoms were studied. Statistical analysis showed that motion sickness, recurrent abdominal pain, sleeping troubles, hyperactivity, cyclic vomiting, dizzines, and limb pain have different incidences in the three groups. These clinical symptoms and family headache history may be considered HR factors and indicate a predisposition to headache in children. The pharmacoclinical study was carried out on 15 migrainous children, five hyperactive and 10 controls. An increased sensitivity of iris adrenergic receptor in both migrainous and hyperactive children was evidenced by measuring phenylephrine-induced mydriasis. The possible etiopathogenetic correlations among headache, hyperactivity, and other HR factors are discussed in accordance with the central theory of headache.
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PMID:Multiple aspects of headache risk in children. 705 96

Independent groups of up to 32 young men exposed in a standard seated posture to one of five conditions of vertical (Z axis) motion for up to 2 h. Exposure was less in the event of vomiting or a volunteer's voluntary withdrawal from the experiment. A control condition, sinusoidal motion of 0.17 Hz and 0.13 G R.M.S., provided the basis for comparison with the remaining four conditions, each produced by the sum of two sinusoids, the fundamental at 0.17 Hz plus the second or third harmonic. The conditions differed in the phase relationship of the fundamental and second harmonic, or in the relative acceleration levels of the two harmonic components. The predicted motion sickness incidence (MSI) for each sinusoid alone was calculated from a previously derived mathematical model and compared with the obtained MSIs. Certain motion conditions provoked unexpectedly high MSIs compared with the control condition. It was found that R.M.S. acceleration is not reliable as the sole predictor of MSI in complex motion. Further data must be obtained before accurate prediction of MSI in broadband motion will be possible.
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PMID:Motion sickness incidence induced by complex periodic waveforms. 711 39

An original scheme of quantitative evaluation of clinical manifestations of motion sickness has been developed. According to the scheme, eight major symptoms of motion sickness: vertigo, nausea, vomiting, sweating, paleness, headache, sleepiness, flaccidity are scored in relation to their manifestations. The scheme has been used in vestibular tests of 57 test subjects. The vestibular test used is tolerance to cross-coupled acceleration. On the basis of the scores quantitative criteria of human tolerance to vestibular exposures have been suggested. It is emphasized that the scheme can be widely used allowing statistical treatment, comparative individual and group analysis of the data obtained.
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PMID:[Quantitative evaluation of the clinical manifestations of motion sickness]. 728 50

Motion sickness experiences were obtained from participants in a 9 month, round the world yacht race. Race participants completed questionnaires on their motion sickness experience 1 week prior to the start of the race, during the race, and following the race. Yacht headings, sea states, and wind directions were recorded throughout the race. Illness and the occurrence of vomiting were related to the duration at sea and yacht encounter directions relative to the prevailing wind. Individual crewmember characteristics, the use of anti-motion sickness drugs, activity while at sea, and after-effects of yacht motion were also examined with respect to sickness occurrence. Sickness was greatest among females and younger crewmembers, and among crewmembers who used anti-motion sickness drugs. Sickness varied as a function of drug type and activity while at sea. Crewmembers who reported after-effects of yacht motion also reported greater sickness while at sea. The primary determinants of motion sickness were the duration of time spent at sea and yacht encounter direction to the prevailing wind.
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PMID:Motion sickness incidence during a round-the-world yacht race. 748 23

The vestibular system is involved in maintaining stable blood pressure and respiration during changes in posture and is essential for eliciting motion sickness-related vomiting. Because the nucleus tractus solitarius (NTS) participates in the regulation of sympathetic and inspiratory outflow and the triggering of emesis, we tested the hypothesis that this region receives vestibular inputs in cats. In one set of experiments, microinjections of the tracer Phaseolus vulgaris leucoagglutinin into the medial and inferior vestibular nuclei labeled projections to the middle and lateral regions of the NTS. In electrophysiological experiments, electrical stimulation of the vestibular nerve modified the firing rates of neurons located in the same regions. Some neurons with vestibular inputs received convergent signals from the abdominal vagus nerve and could potentially mediate motion sickness-related vomiting. Others received convergent baroreceptor inputs and could act as a substrate for some components of vestibulosympathetic reflexes. In contrast, inspiratory neurons in the dorsal respiratory group received little vestibular input, suggesting that vestibulorespiratory reflexes are mediated by cells located elsewhere.
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PMID:Organization of vestibular inputs to nucleus tractus solitarius and adjacent structures in cat brain stem. 752 72

We studied the prevalence, causes and clinical features of paroxysmal vertigo (PV) in the well-defined childhood population of the City of Aberdeen. We applied a screening questionnaire to 2165 children (10% random sample of all children 5-15 years of age) attending schools in Aberdeen. Children with a history of at least three episodes of vertigo over the past year due to unknown causes were invited for clinical interview and examination. Children with PV were compared with a group of children with migraine, and with a group of asymptomatic children matched for age and sex. Forty-five children fulfilled the diagnostic criteria for PV (prevalence rate 2.6%, 95% CI 1.9-3.4). They were noted to have clinical features in common with children with migraine, including trigger and relieving factors, associated gastrointestinal and sensory symptoms, vasomotor changes, and a similar pattern of associated recurrent disorders (such as headache, abdominal pain and cyclical vomiting), atopic diseases and travel sickness. Also, they had a twofold increase in the prevalence of migraine (24%) compared with the general childhood population (10.6%). The overlap in the clinical features of PV and migraine suggests that the two conditions are related and that it is reasonable to continue to regard PV as a migraine equivalent.
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PMID:Paroxysmal vertigo as a migraine equivalent in children: a population-based study. 775 93


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