Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fourteen cases (7 males and 7 females) of neonatal gastro-oesophageal reflux seen at the University of Benin Teaching Hospital in the period 1977-82 were analysed. They all presented with persistent vomiting from birth; 64% of the infants were small for gestational age (SGA). All infants had plain abdominal and chest radiographs and barium meal examination. Eleven neonates had a major gastro-oesophageal reflux but no case of hiatus hernia, oesophagitis or oesophageal stricture was found. Over 80% of patients responded to conservative treatment. There were two deaths. We recommend that SGA newborns presenting with persistent vomiting in the presence of a normal plain abdominal radiograph should be treated as a case of gastro-oesophageal reflux until proven otherwise.
 ...
PMID:Gastro-oesophageal reflux in Nigerian newborn infants. 647 61

Exophiala jeanselmei was isolated from three esophageal cultures over an 11-month period at Lutheran General Hospital. We believe this provides evidence for a new site of isolation, since previous reports of the organism's incidence were confined to skin and lung. Case 1 is an eight-year-old female with a three-year history of gagging and vomiting. Esophagoscopy revealed a mass biopsied as vegetable material. Case 2 is a 66-year-old retired male with a history of obesity, diabetes and spinal stenosis. Following back surgery, the patient developed odynophagia. Esophageal biopsies showed ulceration and bacterial colonies with no evidence of fungus. Case 3 is a 62-year-old male gardener who is also a nail biter. Esophagoscopy revealed a gastro-esophageal stricture with reflux and evidence of a hiatus hernia. Material biopsied was consistent with Barrett's esophagus and evidence of fungi was seen. The esophageal mass of case 1 and the esophageal brushings of case 2 and 3 grew E. jeanselmei. Aspiration, reflux, and mechanical disruption of the esophageal mucosa are possible predisposing factors in colonization of esophageal lesions by this ubiquitous, normally low virulence organism.
 ...
PMID:Isolation of Exophiala jeanselmei associated with esophageal pathology--three cases, laboratory and clinical features. 649 12

It is widely acknowledged that Barrett's esophagus in adults is an acquired condition resulting from prolonged gastroesophageal reflux. Barrett's esophagus is rare in childhood, even though gastroesophageal reflux occurs commonly in the pediatric age group. When a columnar-lined esophagus is present in children, it is often regarded as a congenital anomaly rather than as a consequence of chronic gastroesophageal reflux. Over a 5-yr period (1978-1982), we retrospectively studied Barrett's esophagus in children 19 yr of age or younger who were evaluated for gastroesophageal reflux and whose symptoms warranted esophagoscopy and esophageal biopsy. Esophageal biopsies were performed on 103 patients with gastroesophageal reflux. Thirteen children (age range, 8 mo-19 yr) had Barrett's esophagus, for a prevalence of 13%. Gastroesophageal reflux was documented in these children by upper gastrointestinal radiographs or pH monitoring. Radiographs demonstrated esophageal stricture in 5 of the 13 children; none had hiatal hernia. Children presented with symptoms suggestive of gastroesophageal reflux and esophagitis: vomiting, abdominal pain, odynophagia, dysphagia, and heartburn. All children had a past history of excessive regurgitation during infancy. Histologically, three types of columnar epithelium were present: gastric fundic type (11 patients), junctional-type columnar epithelium reminiscent of gastric cardia (7 patients), and specialized columnar (metaplastic intestinal) type (2 patients). We believe that Barrett's esophagus is more common in children than had previously been appreciated. In these children, we suggest that the distal columnar-lined esophagus resulted from chronic gastroesophageal reflux and is not a congenital anomaly.
 ...
PMID:Barrett's esophagus in children: a consequence of chronic gastroesophageal reflux. 669 Mar 59

Esophageal stricture resulting from gastroesophageal reflux is common among children in Ecuador. The sequence of events is vomiting, recurrent pneumonia, failure to thrive and stricture with resulting malnutrition. The diagnosis is confirmed by barium meal and esophagoscopy. The age of the affected population ranges from one month to 12 years. In the past, surgical treatment included esophageal replacement but the most appropriate current treatment is Nissen fundoplication to restore the gastroesophageal sphincter function.
 ...
PMID:Fundoplication as treatment for gastroesophageal reflux in children. 688 92

Gastroesophageal reflux in infants and children is a complex disease. The diagnosis in 14 operative patients was made utilizing a careful history, barium swallow, technetium radionuclide milk scan, and endoscopy with esophageal biopsy. Symptoms were intractable vomiting, failure to thrive, recurrent pneumonia, apnea, asthma and bronchitis, esophagitis, and esophageal stricture. The pernicious aspects of this disease include a potentially significant mortality in children with severe apnea episodes, increased morbidity with esophagitis, and psychosocial disruption for those children that progress to the teenage years with recurrent vomiting, rumination, heartburn and stricture formation. A high incidence of gastroesophageal reflux unresponsive to medical management was noted with esophageal atresia and neurologic disease. The Nissen fundoplication was used in all patients and proved an effective procedure with a low morbidity and recurrence rate.
 ...
PMID:Gastroesophageal reflux in children: an underrated disease. 707 8

A A retrospective study of 101 elderly patients who were referred for upper gastrointestinal barium studies showed that this led to a change of management in 36 patients. The commonest management change was endoscopic referral (10 patients). However, in only on patient did this sequence lead to surgery and this was merely palliative. Dysphagia, vomiting and weight loss were shown to be the presenting features most likely to result in an abnormal barium study. The most frequently detected abnormalities were hiatus hernia, reflux, oesophageal stricture, peptic ulcer and gastric carcinoma.
 ...
PMID:Upper gastrointestinal barium studies in the elderly: follow-up in 101 patients. 711 71

A 2-year-old girl with persistent vomiting of solid foods was evaluated; the diagnosis was esophageal muscular ring. This rare congenital anomaly and its differentiation from esophageal stricture are discussed. This case represents a variation of the esophageal malformation associated with the VACTERL association.
 ...
PMID:Esophageal muscular ring and the VACTERL association: a case report. 725 97

A patient with persistent vomiting in pregnancy due to oesophageal stricture secondary to reflux oesophagitis is reported. Reflux oesophagitis is common during pregnancy but usually responds to small frequent meals, the avoidance of certain positions and simple antacid therapy. Where symptoms are persistent and become worse in late pregnancy we suggest that more energetic therapy in the form of cimetidine or alginate antacid mixture (Gaviscon) should be considered to prevent oesophageal stricture formation.
 ...
PMID:Oesophageal stricture due to reflux oesophagitis in pregnancy. Case report. 730 80

One hundred children underwent Nissen's fundoplication for complications of gastroesophageal reflux. Indications for fundoplication included refractory pneumonia, apneic spells, intractable vomiting, failure to thrive, esophagitis, esophageal stricture, and Sandifer's syndrome. Except for those with life-threatening complications, fundoplication was performed only in those who had failure with a strict medical antireflux regimen. Four patients were not helped by operation or had a recurrence of symptoms. Of these, three with refractory pneumonia were judged to be failures of selection since reflux was absent postoperatively. The fourth had massive reflux and recurrent vomiting. Eight other patients had radiologic evidence of reflux postoperatively. Six of these were asymptomatic and two had minor symptoms. There was one death and 11 postoperative complications.
 ...
PMID:Surgical treatment of gastroesophageal reflux in children. Results of Nissen's fundoplication in 100 children. 742 52

The clinical features of abnormal gastroesophageal reflux in infants and children extend beyond repeated vomiting and include dysphagia, pain, bleeding, failure to thrive, esophageal stricture, and recurrent respiratory symptoms including aspiration pneumonitis and cyanotic attacks. The unreliability of the traditional barium swallow examination as a diagnostic test is well known. This study reports the results of endoscopic assessment and esophageal biopsy in 100 infants and children and relates them to the clinical findings and the changes in the contrast esophagogram. The results show that further valuable diagnostic information can be gained from endoscopic examination of the esophageal mucosa, especially when there is esophagitis with ulceration, bleeding, or stricture. Endoscopic biopsies are useful to confirm the presence of esophagitis but biopsies alone do not give absolute diagnostic information.
 ...
PMID:Endoscopy and biopsy in gastroesophageal reflux in infants and children. 743 49


<< Previous 1 2 3 4 5 Next >>