Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From January 1963 to December 1965 inclusive 192 men with duodenal ulcer were treated by elective truncal vagotomy and pyloroplasty with one death. Ten subsequent deaths were due to causes unrelated to the ulcer or operation, and 17 patients became untraceable. The remaining 164 patients have been followed up for five to eight years. The late results have been compared with those obtained in a previous study of patients five to eight years after truncal vagotomy and gastroenterostomy, truncal vagotomy and antrectomy, and subtotal gastrectomy respectively for duodenal ulcer.Of the various postgastric operation syndromes early dumping, late dumping, bilious vomiting, and diarrhoea were all less frequent, but not significantly so, after vagotomy and pyloroplasty than after vagotomy and gastroenterostomy.Recurrent ulceration was commoner after vagotomy and pyloroplasty than after all the other operations, the incidence of proved and suspected recurrent ulcers being respectively 6.7 and 7.3% after vagotomy and pyloroplasty, but only 2.5 and 5.9% after vagotomy and gastroenterostomy, 0 and 5.2% after vagotomy and antrectomy, and 0.9 and 3.7% after subtotal gastrectomy. The differences between vagotomy and pyloroplasty and vagotomy and antrectomy or subtotal gastrectomy are statistically significant, but those between vagotomy and pyloroplasty and vagotomy and gastroenterostomy are not.Overall assessment (Visick grading) of the outcome gave poorer results after vagotomy and pyloroplasty than after any other operation, with 14% of category IV cases after vagotomy and pyloroplasty, 11% after vagotomy and gastroenterostomy, 8% after vagotomy and antrectomy, and 6% after subtotal gastrectomy-differences that are significant between vagotomy and pyloroplasty and vagotomy and antrectomy or subtotal gastrectomy but not between vagotomy and pyloroplasty and vagotomy and gastroenterostomy.In the light of these findings it is suggested that truncal vagotomy and pyloroplasty has not lived up to expectations and its place as the currently most popular procedure in the elective surgical treatment of duodenal ulcer should be reconsidered.
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PMID:Five- to eight-year results of truncal vagotomy and pyloroplasty for duodenal ulcer. 500 73

The results are reported from the treatment of 30 patients with the Bulgarian preparation biomet, which is a blocker of histamine H2-receptors. The treatment lasted 20 days with 3 X 20 mg biomet, after meals, and 400 mg in the evening before going to bed. Pains disappeared in 86,6 per cent with biomet treatment, pyrosis--in 95,8 per cent, eructation--in 95,3 per cent, nausea--in 84,7 per cent, vomiting--in 100 per cent of the patients, etc. (the clinical symptoms completely disappeared in 76,7 per cent after the treatment and were substantially reduced in 16,7 per cent). A statistically significant reduction of the basic parameters of gastric secretion and acid output occurred after biomet treatment as compared with the initial values. The fibroendoscopic study of the duodenal ulcer, after the treatment, revealed a complete epithelization in 52 per cent and diminished ulcer size--in 44 per cent. No pronounced adverse effects were observed during biomet treatment. The Bulgarian preparation biomet is fully equivalent to the English Cimetidine (the latter being more expensive) and should find a broad application in the treatment of duodenal ulcer.
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PMID:[Treatment of duodenal ulcer with biomet]. 614 53

A prospective, randomized, controlled trial was performed to study truncal vagotomy and drainage (TV), selective vagotomy and drainage (SV) and parietal cell vagotomy (PCV) as elective treatment for duodenal ulcer. Five years postoperatively, 233 patients were available for study: 73 TV, 81 SV and 79 PCV. The ulcer recurrence rates were 13.6, 19.8 and 30.4 per cent respectively. The incidence of severe dumping was 4.9, 10.9 and 1.9 per cent; of severe diarrhoea 4.9, 6.3 and 1.9 per cent; of severe pain/dyspepsia 3.3, 6.3 and 3.8 per cent and of severe nausea/vomiting 0, 1.6 and 0 per cent respectively. Women suffered more postvagotomy symptoms than men. After treatment of recurrences and postvagotomy symptoms, more patients after PCV achieved excellent results than after TV and SV, as recurrences were easier to treat than severe postvagotomy symptoms. The only factor found contributing to the high ulcer recurrence following PCV was the large number of surgical trainees operating in the trial.
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PMID:Prospective controlled vagotomy trial for duodenal ulcer: results after five years. 637 9

Carcinoma of the extrahepatic bile ducts was treated in 25 patients by radiation therapy between 1974 and 1981. Seventeen patients were men and eight were women, and the average age was 59.2 years. Cobalt-60 beam or 10 MV x ray was used for radiation therapy, with the total dose ranging from 10 Gy to 60 Gy. Twenty-one patients received 40 Gy or more. Twenty-two patients underwent surgical procedures such as percutaneous transhepatic drainage or T-tube drainage before radiation therapy. Total bilirubin level decreased after radiation therapy in 21 patients. Side effects included loss of appetite, nausea, vomiting, general fatigue, and duodenal ulcer. The mean survival of all patients was 9.2 months after completion of radiation therapy. The longest survival has been for 6.5 years, and the patient is alive and well as of this writing. Radiation therapy proved effective in treatment of carcinoma of the extrahepatic bile ducts in terms of palliation and prognosis.
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PMID:Radiation therapy of carcinoma of the extrahepatic bile ducts. 640 3

Using a clinico-psychological method, 170 patients with functional psychosomatic pathology of the alimentary apparatus (functional dysphagia, neurogenic vomiting, gastralgias, the syndrome of the irritable large intestine) were examined. The study showed that these diseases manifested themselves after a considerable psychotraumatic situation. In women, the role of the stressor was played by disruptions in familial relations while in men, job-related stresses were usually involved. Particular vulnerability of the gastrointestinal tract expressed in episodic dysfunction from early childhood was a predisposing factor in all observations. The personality characteristics of the patients (as judged from the data obtained by techniques of Taylor, Aizenk, M.H.Q., "incompleted sentences" and the index of the stability-instability of marriage) are characterized by high anxiety, neurotism, depression, and liability to obsessive-phobic reactions. Comparison of the research findings with the relevant results obtained in an organic psychosomatic disease (duodenal ulcer) demonstrated that with further somatization of the affect, the above personality features tend to decrease. According to the data obtained functional psychosomatic disturbances progress to organicones only in 7.4% of cases.
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PMID:[Several functional psychosomatic diseases of the gastrointestinal tract]. 650 80

Forty endoscopic examinations of the upper gastrointestinal tract were performed in 38 infants with an age range from 2 days to 12 months. The main indications were upper gastrointestinal bleeding, chronic intractable vomiting, and small intestinal biopsy. Duodenal ulcer, hemorrhagic gastritis, and gastric erosions were the most common causes of upper gastrointestinal bleeding in infancy. An acute viral infection with fever, aspirin ingestion, and diarrhea frequently preceded gastrointestinal bleeding from duodenal ulcer and gastric erosion. Four of the 27 bleeding patients demonstrated no abnormality endoscopically.
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PMID:Endoscopic examination of the upper gastrointestinal tract in infancy. 660 Jun 94

Between 1973 and 1976, 153 patients (124 men, 29 women) with uncomplicated, chronic, duodenal ulcer were entered into a prospective randomized trial of highly selective vagotomy (HSV) or truncal vagotomy and pyloroplasty (TVP). The study was conducted in four Manchester hospitals and the operations were performed by consultants or chief registrars. The follow-up was conducted by personal interview using a standardized questionnaire. The medical gastroenterologist did not know which type of operation the patient had had. The patients who had symptoms were referred back to the surgeon who performed the operation. The clinical laboratory and follow-up data were analysed by computer. There were no operative deaths. Three patients died from unrelated causes, 13 were lost to follow-up; 137 (89.5%) were followed up for a mean of 4.1 years (range from 2.5 to 5.5 years). A modified Visick grading was used to assess the results of surgery. The outcome was good in 82% after TVP and 73% after HSV. This difference and those in the incidences of early or late postprandial dumping, bilious vomiting, weight loss, anemia and heartburn were not significant. Diarrhea was more frequent after TVP (13.4%) than after HSV (1.4%); although the difference was significant (p less than 0.025), this complaint did not present a serious clinical problem. Ulcers recurred in 15 (21.4%) patients following HSV and in 5 (7.5%) after TVP; this difference was statistically significant (p less than 0.05).
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PMID:Randomized trial of elective highly selective or truncal vagotomy in chronic duodenal ulceration. 682 97

Billroth II resection was carried out in 1000 duodenal ulcer patients in the period 1948-1956. Twenty-two to thirty years later, gastroscopy and biopsy was performed in 196 of 423 survivors. Chronic atrophic gastritis appeared in 93 per cent of the cases, 47 per cent showed slight and 46 per cent severe changes. Seven per cent had normal mucosa. The microscopic grade of gastritis proved to be independent of age, alcohol and tobacco consumption and serum gastrin. No correlation between clinical status, such as dumping, diarrhoea, vomiting and pain, haematological parameters and the microscopic grade of gastritis, could be found. It is suggested that gastritis might be caused by reflux of bile, pancreatic and intestinal juices, and that postgastrectomy symptoms and anaemia do not depend on the microscopic grade of gastritis.
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PMID:Causes and clinical significance of gastritis following Billroth II resection for duodenal ulcer. 686 Sep 6

Annular pancreas--a congenital malformation consisting of a ring of pancreatic tissue around the second part of the duodenum--is a rare surgical condition in adults. It may be responsible for occlusion in the newborn, but frequently remains latent or does not reveal itself until adulthood, usually around the age of 40. The only symptoms are ulcer-like epigastric pains; vomiting occurs at a late stage and jaundice irregularly. Hypotonic duodenography shows, at best, duodenal stenosis, the extrinsic origin of which is disclosed by fiberoscopy. Pre-operative investigations should aim at detecting a gastro-duodenal ulcer or an associated chronic pancreatitis. Owing to the presence of an excretory duct within the ring, section of the latter entails a risk of fistulisation. The best prospects of cure are offered by digestive tract derivation procedures: latero-lateral duodeno-duodenostomy, gastro-enterostomy and duodeno-jejunostomy on a Y-shaped excluded jejunal loop.
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PMID:[Annular pancreas in the adult (author's transl)]. 696 84

The therapeutic effect of four new variants of the preparation Almagel was studied in 100 patients with duodenal ulcer (25 patients in each group were examined)---Flatugel, Flatugel A, Almagel-Neo. The pains, with the treatment faded away in 60 to 68% and abated in 25 to 32% of the treated in the separate groups. As compared with the control group, the symptom constipation was influenced in a higher per cent by the new preparations, explained by the twice higher dose of magnesium hydroxide in the new almagel derivatives. Flatugel A and almagel A-neo had the best upon vomiting, due to the anesthesin, contained in them. In half of the patients, the clinical symptoms disappeared during the first week after the initiation of the treatment and after its termination the clinical manifestations remained unaffected in only 8% of the patients. After the 20-day treatment with the new modifications of almagel, the ulcer niche disappeared in 25-29% and its dimensions were reduced in 30-50%. No significant differences were established as regards the effect upon the rest of the clinical symptoms and ulcer niche among the new preparations themselves and each separate preparations as compared with the control group. The new almagel modifications show a tendency of reduction of gastric secretion and acidity 12 hours after the termination of the treatment as compared with the same prior to treatment, but the differences are statistically insignificant. The new variants of almagel have a pleasant taste, they are taken with pleasure and give no toxic and allergic side effects.
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PMID:[Clinical trial of the Bulgarian preparations, flatugel and almagel-neo in duodenal ulcer]. 699 56


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