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Query: UMLS:C0042963 (vomiting)
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An obstetrical practice based at a university hospital in Jerusalem has studied the offspring of 9,894 women who were pregnant at least once during the years 1966 through 1968, and discovered that the neonatal mortality rate was 2 to 3 times higher in infants born to women who reported a previous induced abortion. Among the women studied, 7.2% reported at least 1 previous abortion; immigrants from South Africa tended to have the highest rate of abortion, whereas the lowest rate was observed in the Arab population. An inverse relationship was detected between a history of induced abortion and the following: the degree of religious observance; maternal age at the time of marriage; and maternal age at the time of past deliveries. A positive correlation was observed between a history of induced abortion and the present age of the mother; smoking; Caesarian section; bleeding during pregnancy; vomiting during pregnancy; and the use of medications during the 1st trimester of the present pregnancy. The women in this study delivered a total of 11,057 infants between 1966 and 1968; infants born to mothers who reported a previous induced abortion experienced a higher neonatal mortality rate and were more likely to be low birth-weight infants, when compared to the group of infants whose mothers did not report a previous induced abortion.
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PMID:[Neonatal death after induced abortion]. 98 85

The authors have studied the influence of mechanical and hormonal contraceptives on the organism of women, more specifically on their menstrual and child-bearing function. The studied women were divided into 2 groups: in the 1st group were 1532 women wearing intrauterine devices and 200 women examined in the remote period. The 2nd group consisted of 218 women using Infecundin for contraceptive purposes. The length of the observation period varied from 1 to 7 years. All women observed were healthy and of reproductive age. They were between 20 and 45 years of age. They all had a 2-phase menstrual cycle until they started to use a contraceptive. The women wearing IUD's had been using them for 6 months to 5 years. 93.4% did not show any sign of complication; 7.9% were experiencing various complications such as menstrual disorders, acute inflammations of the sexual organs; 38 women became pregnant; there was one case of spontaneous abortion; and 2 cases of extra-uterine pregnancy. 23 pregnancies went to term normally and 12 cases necessitated an induced abortion. The women from the 2nd group had been taking Infecundin for 3 months, 6 months, 12 months and over 1 year. 17 of these women were complaining of side effects such as nausea, vomiting, cardiac pain, swelling of the mammary glands, weight gain, headaches and hepatic disorders. Some histological examinations of the endometrium showed signs of endometritis. 10 women discontinued the use of Infecundin. On the whole, hormonal and mechanical contraceptives are of satisfying efficiency. They do not appear to provoke any significant complications in the menstrual and child-bearing functions of the woman. However the use of oral contraceptives tends to provoke a pronounced atrophy of the mucous membrane in the uterus. Therefore it is advisable to prescribe oral contraceptives in cycles separated by 2 to 3 month interruptions.
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PMID:[Menstrual and child-bearing functions of women using mechanical and hormonal contraceptives]. 99 12

A study involving 115 women was conducted to determine the effectiveness of doses of PGR2alpha (prostaglandin F2alpha) and urea for 2nd trimester abortions. 2.5-20 mg of PGF2alpha was combined with 80 gm of urea to induced abortion, with 10 mg being the optimal dose. Only 2 patients had not aborted after 36 hours and only 6 patients required a 2nd injection at 24 hours; laminaria tents did not shorten abortal times. For 33 multiparous patients the mean abortal time was 14.3 hours and for 82 nulliparous women, the mean abortal time was 16.4 hours. 30% of the women had the placenta removed operatively using intravenous sedation. Vomiting occurred in 19 women, nausea in 4 women, 8 became febrile, 2 received blood transfusions for hemorrhage, and 2 had a 4-cm cervical laceration
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PMID:Intra-amniotic prostaglandin F2alpha and urea for midtrimester abortion. 100 22

The definition, etiology, and treatments for frigidity, dyspareunia, and dysmenorrhea are summarized. Frigidity is an absence or lack of sexual pleasure sometimes to the extent of lack of orgasm. It can be due to fear, unresolved oedipal complex, anger, or depression. Psychotherapy is helpful, with antidepressants if appropriate. Dyspareunia is vaginal pain during sexual relations, and derives from the same types of psychological problems as frigidity. Dysmenorrhea can be related to conscious or unconscious rejection of the role of woman or mother. It is treated by psychotherapy. The sexual problems that are relieved easily by physical techniques or education are minor, while those deep in the personality and sustained by psychological mechanisms are major. Female sexual dysfunctions related to the female role are frigidity, dyspareunia, and vaginismus; those associated with the maternal role are dysmenorrhea, amenorrhea, false pregnancy, vomiting in pregnancy, sterility, and sponaneous abortion.
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PMID:[Sexual dysfunctions of emotional origin in women]. 103 19

Associations between previous induced abortion and demographic and health factors in pregnancy were measured in 9 874 women who gave birth and who had been interviewed during pregnancy. Previous abortion was most rare among women having their first baby and increased with increasing birth order up to the fourth, thereafter decreasing. It was positively correlated with maternal age and negatively with age at marriage. There was no effect of years of schooling, when other variables were taken into account, but there were significant differences between ethnic groups, abortion being commonest among Jewish women from North African countries and more prevalent in those from western and Asian countries than in the second-generation Israel-born or in Arab women.Women who reported abortions were less likely to be strict as regards religious observance and less likely to have had a previous stillbirth or child death, other variables being equal. They were more likely to be smokers or former smokers and to be delivered of their babies in certain obstetric units. They more often reported vomiting, bleeding, and medication in early pregnancy. On the other hand, there was no significant association with diabetes, anaemia, blood groups, or season of birth.The findings show that women reporting previous induced abortions differ significantly from other pregnant women in a wide range of demographic and health characteristics. Such women may also be biased for complications of pregnancy and outcome, particularly if selected from a clinic population. Observations that indicate a deleterious effect of induced abortions on subsequent pregnancy outcomes must therefore be interpreted with considerable caution.
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PMID:Characteristics of pregnant women who report previous induced abortions. 108 3

Of 53 salmonella serotypes isolated from dogs, S typhimurium and S anatum have been the most commonly isolated. Surveys have disclosed that over 20% of the dogs in a population may be infected. Simultaneous, multiple infections with 2 or more serotypes are not unusual. Nonclinical salmonellosis occurs in most cases. The severe form of the disease is manifested by diarrhea, vomiting, fever, depression, abortion, and death. Dogs may remain carriers and fecal shedders and thus serve as sources of salmonellosis for man and other animals. A number of documented transmissions from dogs to human beings have been recorded. Such infections in man have been severe.
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PMID:Canine salmonellosis: prevalence, epizootiology, signs, and public health significance. 110 2

In order to evaluate the efficacy and acceptability of 15(S)-15-methyl-prostaglandin F2alpha (15-me-PGF2alpha) for pregnancy termination, we induced 30 abortions with single intra-amniotic injections of 2,5 mg of 15-me-PGF2alpha and 25 abortions with intra-muscular 15-me-PGF2alpha administered 200 mug initially and 300 mug every third hour until 30 hrs or abortion. Abortion occurred within 30 hrs in 97% of cases in the intra-amniotic group, with a mean abortion time of 17,6 hrs and in 80% in the intramuscular group, with a mean abortion time of 15.0 hrs. Neither parity nor gestational age was significantly related to the abortifacient efficacy of 15-me-PGF2alpha. No serious complications occurred. Vomiting (83-84%) and diarrhoea (23-92%) were the most common complaints. Uterine contractions were more painful if induction was effected with intra-amniotic rather than intramuscular injections. 15-me-PGF2alpha appears to be an effective and practicable abortifacient which can be used intra-amniotically or intramuscularly according to the ease of amniocentesis.
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PMID:Induction of abortion with intra-amniotic or intra-muscular 15(S)-15-methyl-prostaglandin F2alpha. 110 93

In a preliminary study a single extra-amniotic injection of 1.5 mg of prostaglandin E-2 incorporated into an aqueous viscous gel was given to 24 patients aborted within 24 hours, and the mean induction-abortion interval (plus or minus S.E. of mean) was 13.5 plus or minus 1.5 hours. Vomiting occurred in seven patients, and transient severe uterine cramps, pallor, nausea, and shivering occurred in one patient immediately after injection. Complete abortion occurred in 20patients. A delay in the time taken to abort seemed to be associated with an immediate and rapid rise in uterine tone after the injection which required prompt analgesia; this probably reflected rapid decidual absorption and dissolution of the prostaglandins away from their site of action. The degree of distention of the catheter-retaining balloon did not influence abortion times.
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PMID:Single extra-amniotic injection of prostaglandin E2 in viscous gel to induce mid-trimester abortion. 111 61

A series of 100 consecutive patients seeking pregnancy termination in pregnancy weeks 7-20 were treated with a schedule of 20-mg vaginal suppositories containing prostaglandin E2 (PGE2); the schedule was being tested for its efficacy, specifically reduction of total dose and related side effects. 94 of the 100 patients were aborted within an arbitrary time span of 36 hours. Total drug dose ranged from 40-160 mg. 31 patients received augmentative intravenous oxytocin. Induction-abortion interval varied from 6-32.5 hours. Of the 97 successes, 76 were classified as complete abortions. No significant differences were noted in midtrimester groups based on increasing parity, although parous patients in gestation week 13-15 seemed to have the best results, based on average interval time. No sepsis or need for transfusion was encountered. Side effects were emesis (n-75), diarrhea (n=17), and drug fever (n=66); less frequent side effects included headache, breast tenderness, and vasomotor symptoms (n=13, 1, and 1, respectively). The midtrimester patient results compared favorably with results of studies using saline for abortifacient. The number of first trimester patients was too small to yield any conclusion.
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PMID:Vaginally administered prostaglandin E2 as a first and second trimester abortifacient. 111 58

This study determines whether induction of second trimester abortions with intraamniotic prostaglandin F2alpha (PgF2a) could be facilitated by use of intravenous oxytocin, and whether side effects of prostaglandin administration could be minimized by using lower doses of prostaglandin in conjunction with oxytocin. 26 healthy pregnant females aged 16 to 39 years (16 to 26 weeks gestation) were divided into 2 groups: group 1 consisting of 12 patients who had intraamniotic injection of PGF2a 25 mg. followed by additional doses of 5 to 25 mg. injected at intervals of 8 to 10 hours (mean dose, 40.2 mg.), and group 2, consisting of 14 patients who had intravenous infusion of oxytocin 2 hours after intraamniotic injection of 25 mg. PGF2a (mean dose, 28.2 hours). 9 out of 12 patients in group 1 aborted within 36 hours (mean abortion time, 24 hours and 41 minutes) while all patients in group 2 aborted within 28 hours (mean abortion time, 15 hours and 37 minutes). Nausea, vomiting, and diarrhea occured in 9 group 1 patients while 2 patients in group vomited. There were no significant changes in blood pressure, heart rate, respiration or metabolic parameters. This study shows that under carefully controlled conditions, administration of intravenous infusion of oxytocin following intraamniotic administration of PgF2a shortens injection to abortion time.
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PMID:Mid-trimester abortion with intra-amniotic prostaglandin F2 alpha and intravenous oxytocin infusion. 113 39


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