Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042963 (vomiting)
 31,883 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case history of an 18-year-old woman admitted 2 days after undergoing a therapeutic abortion with acute abdominal pain is reported. The patient denied nausea or vomiting, but she appeared very ill with a temperature of 38.3 degrees centigrade. Pelvic examination was normal. The possibility of gonococcal perihepatitis was considered. When endocervical secretions were Gram-stained, gram-negative intracellular diplococci and neisseria gonorrhoeae were cultured. The patient had only 1 sexual partner, but that partner had had intercourse with at least 2 other women during the same period he was intimate with the patient. The patient responded to intravenous penicillin and was discharged after 5 days of treatment. It was suspected that dissemination of the gonococci was during the therapeutic abortion via the fallopian tubes. Neither the patient nor her partner, it was emphasized, showed genital symptoms, therefore the need to screen potential abortion patients is acute with gonorrhea at the epidemic stage.
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PMID:Occurrence of gonococcal perihepatitis after therapeutic abortion. 44 81

Prostaglandin derivative SH B 286 (Sulprostone) was administered to 128 induced abortion patients in the 1st trimester of pregnancy on an outpatient basis the evening before curettage was to be performed. 25 mcg of the preparation was injected directly into the uterine wall. There were 5 cases of vomiting, 2 of short term circulatory collapse, and 1 case of abdominal spasms. 7.2% described the contractions as "strong," and 7.8% described the accompanying bleeding as "heavy," compared to menstrual bleeding. Curettage was performed ca. 15 hours after the injection; dilatation could be effected without difficulty. Histological tests showed that the embryo had been expelled in 47.1% of the patients prior to the curettage, with an average expulsion time of ca. 6 hours. No excessive blood loss was reported. The rate of infection was 3.1%.
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PMID:[Outpatient termination of pregnancy via intramural single-shot application of the prostaglandin derivative sh b 286 (sulproston) (author's transl)]. 45 62

10 patients with missed abortion, intrauterine fetal death or hydatifidiform mole were given 15-(S)-15-methyl prostaglandin F2 alpha intramuscularly for the induction of labour or, in 2 cases, to obtain softening of the cervix prior to curettage. The mean time interval between induction and abortion was 6 h 9 min, with a mean dosage of 890 mcg prostaglandin per patient. Vomiting or diarrhoea occurred in 7 patients. Apart from a drop in haemoglobin concentration in 1 patient and a temporary increase in white cell count in 6 patients, no other pathological laboratory findings were detected. We conclude from these results and the relevant literature that the intramuscular administration of 15-(S)-15-methyl prostaglandin is an effective and safe means of inducing labour in missed abortion, intrauterine fetal death and hydratidiform mole.
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PMID:[Administration of 15-(S)-15-methyl prostaglandins F2 alpha in intrauterine fetal death, missed abortion and hydatidiform mole (author's transl)]. 46 45

The results of 98 therapeutic abortions in the first and second trimester of pregnancy using F prostaglandins are reported. The prostaglandins were eigher administered by fractionated extra-aminotic PGF2 alpha, intramuscular 15-methyl PGF2 alpha or extra-amniotic or intracervical single shot 15-methyl PGF2 alpha. The induction abortion time of 13 hours and 15minutes for the single shot and 14 hours and 28 minutes for the intramuscular administratic with the prostaglandin derivatives is shorter than with natural prostaglandins which showed a mean induction to abortion time of 19 hours and 30 minutes. The blood loss was low in all groups at approximately 75 mls. Side effects are least with the single shot method (11%). Two patients had nausea, two patients had vomiting, three patients had flush or lower abdominal cramps. The intramuscular administration showed the highest frequency of side effects (80%). In the first trimester the single shot method always leads to sufficient cervical dilatation although the abortion rate was low at 59%. During the second trimester a high abortion rate is found. Therefore this method can be recommended for therapeutic abortions.
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PMID:[New considerations in therapeutic abortions using a second generation prostaglandins (author's transl)]. 47 57

Sulprostone was administered to 628 women, 14-47 years of age, to induce abortion in cases of intact and disturbed pregnancies in the 5th - 37th weeks. The preparation was administered in 30 cases as a suppository, in 86 cases intra- or extraamnially, in 302 cases intravenously (i.v.) and in 210 cases intramuscularly (I.m.). The suppositorial administration cannot be used in induce abortion. A complete abortion was induced in 10 of 56 women in the first trimester and in 15 of 20 women in the second trimester with an extraamnial instillation of sulprostone, and in 90% by intraamnial infusion. The best results from i.v. administration of sulprostone were obtained by administering a total dosage of 1000 mcg of the drug over a 10 hour period. Incomplete or complete abortion was induced in 84.7% of the women in the first trimester who received sulprostone i.v. with an average induction-abortion interval (i.a.i.) of 12.2 hours. Complete abortion was obtained in 90% of the women in the 2nd trimester who received sulprostone i.v., with an average i.a.i. of 13.2 hours for intact and 9.3 hours for disturbed pregnancies. 30 patients less than 6 weeks pregnant received two 500 mcg i.m. injections of sulprostone to induce bleeding. 167 women in the early second trimester were given sulprostone i.m., 1-3 doses of 500 mcg at 4-8 hr. intervals. An abortion resulted in 50% of the patients after 1 injection. The rate of incomplete abortions increased with increased dosage. An average i.a.i. of 11.4 hours was recorded. In both i.v. and i.m. applications, increased dosage did not cause increased effectiveness, but increased side effects. 23.5% of the patients experienced nausea, 15.1% vomiting, and less than 1% diarrhea. I.m. administration is preferred up to the 12th week of pregnancy, while i.v. administration is preferred for disturbed pregnancies after the 12th week.
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PMID:[A new therapeutic approach for terminating intact and disturbed pregnancies: three years of experience with the prostaglandin E2-derivative sulprostone (SHB 286) (author's transl)]. 47 68

The authors report on their experience with anesthesia in 380 cases of induced abortion. Paracervical block was used in 39 cases, (10.2%), with no complications. General anesthesia was used in 3 different ways: 1) narcoanalgesia combined with propanidid and dextromoramide, used on 103 women (21.1% of cases), resulted in a large number of cases of vomiting; 2) narcoleptoanalgesia with propanidid, dextromoramide and droperidol, used on 143 patients, (37.6%), resulted in fewer cases of vomiting; and, 3) narcoanalgesia with CT 1341 and dextromoramide, used on 79 patients, (20.7%), resulted in an even smaller number of cases of vomiting.
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PMID:[Abortion and the use of anaesthesia. Observations after two years' experience (author's transl)]. 48 82

Medicaments are used to prepare for instrument abortions in the 1st trimester and as inducers of abortion in the 2nd trimester. The effects, side effects, and dangers depend on the substances used and the route of application, which can be vaginal, cervical, injection, instillation, extraamniotic, intraamniotic, intravenous, or intramuscular. In the past, intraamniotic instillation of a 20% salt solution was the most common 2nd trimester method in Japan, the US, and Eastern Europe, giving a success rate of 90%. Serious side effects prompted substitution of extraamniotic instillation, which rarely produces serious side effects. Instillation of a 60% urea solution into the amniotic fluid in combination with oxytocin or prostaglandin produces an abortion in 13-21 hours, with a failure rate of 3% and a frequency of cervical laceration of under 1%. Extraamniotic use of a .1% solution of rivanol yields a success rate of about 85%, with a relatively long average time to explusion of 24-41 hours. In case of failure the procedure can be repeated. The advantage of the Rivanol method is the rarity of infectious complications. Alcohol is not used as a human abortifacient because it produces necrosis in the decidua and placenta. Prostaglandins are used in most 2nd trimester abortions. Research is underway to identify derivatives that will have an extended uterine impact without serious side effects. Different routes of administration have different effectiveness rates and dangers. All prostaglandins cause side effects including pain during uterine contractions, gastro-intestinal reactions, nausea, vomiting, fever, and headaches. Specific preparations are associated with other effects, some of them life-threatening. Emergency treatment should be available when these substances are used. Adjuvant measures may be employed before adminstration of an abortifacient agent to soften the cervix, or after administration to hasten the procedure. The choice of procedure depends upon the personality, health, and other characteristics of the woman and the experience of the doctor and the clinic.
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PMID:[Chemical methods of abortion]. 48 68

This article discusses the parallel results of interruption of advanced pregnancy (14-20 weeks) with Prostaglandin F2alpha (PGF2alpha) and a 20% NaCl solution. 40 mg of PGF2a was administered intraamniotically with another 20 mg administered if abortion did not occur within 24 hours. The 20% NaCl solution was given intraamniotically and without aspiration of the fetal liquid in a quantity of 200 ml in some of the patients. Likewise, with the 20% NaCl solution, an intravenous (IV) infusion of syntocyne was administered drop by drop (average dosage 0.19 Ij/minute). This procedure was carried out until abortion of the fetus took place in 1/2 of the patients, while in the second 1/2 it was performed until abortion of the placenta. The abortion was considered a failure it it did not take place within 48 hours (with administration of both agents). In 67 cases, abortion was successful with PGF2alpha. In 4 patients it failed and was terminated by induction with syntocyne. However the 20% NaCl solution and IV syntocyne infusion resulted in abortion in 71 patients. The following number of incomplete abortions was registered: 20.9% with PGF2alpha and 16.9% with hypertonic NaCl solution. The latency period was 22.21 hours with PGF2alpha and 21 hours with 20% NaCl solution. Side effects (vomiting, diarrhea, fever) were higher with the PGF2alpha. 2 cases of diffuse peritonitis were registered, each due to each one of the agents, and both patients recovered. Better results with the 20% NaCl were due to the parallel IV infusion of syntocyne. However, caution must be exercised as this utertonic may cause genital organ lesions.
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PMID:[Comparison of the results of interruption of advanced pregnancy using prostaglandin F2-alpha and a NaCl solution]. 50 72

250 mcg 15(S)-15-methyl-prostaglandin F2alpha (PGF2alpha) was administered intramuscularly every 3 hours to 10 women between 12-18 weeks gestation. All aborted within 20 hours with a mean induction-abortion interval of 14.1 hours. 8 patients experienced side effects such as nausea, vomiting, and diarrhea. (author's modified)
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PMID:[Induced abortion with intramuscular administration of 15(S)-15methyl-prostaglandin F 2 alpha]. 56 Jul 70

Intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha (15-Me-PGF2alpha) induced abortion in 38 patients who had failed to abort with other techniques, such as intra-amniotic instillation of saline or PGF2alpha and intravaginal insertion of prostaglandin-impragnated Silastic devices. The intramuscular injections of 15-Me-PGF2alpha were initiated when the original abortion techniques, even when augmented by intravenous oxytocin, failed to produce expulsion of the fetus. The dose schedule was 250 microgram or 500 microgram every 2 to 4 hours, and the concomitant intravenous oxytocin was continued at a rate of 167 mU/minute. Of the 38 patients, 26 aborted with two or fewer injections of 15-Me-PGF2alpha, and 30 patients required only 1 mg of the drug to expel the fetus successfully. The mean time from the first injection of 15-Me-PGF2alpha to the expulsion of the fetus was 5.25 hours; one-half of the patients aborted in less than 4 hours. The placenta was expelled spontaneously in 15 patients, removed manually from the vagina in 18, and removed by sponge forceps in 3. Two abortions were incomplete and surgical intervention was required. Twenty-eight patients (74%) experienced gastrointestinal disturbances, chiefly vomiting and diarrhea. Intramuscular administration of 15-Me-PGF2alpha eliminates the need for repeated amniocentesis, and the dose may be adjusted to meet the precise requirements of the clinical situation.
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PMID:The effects of intramuscular injections of 15(S)-15-methyl prostaglandin F2alpha in failed abortions. 56 11


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