Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042961 (volvulus)
4,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alpha thalassemia-mental retardation, X-linked (ATR-X) syndrome is a rare genetic disorder with a variety of clinical manifestations. Gastrointestinal symptoms described in this syndrome include difficulties in feeding, regurgitation and vomiting which may lead to aspiration pneumonia, abdominal pain, distention, and constipation. We present a 19-year-old male diagnosed with ATR-X syndrome, who suffered from recurrent colonic volvulus that ultimately led to bowel necrosis with severe septic shock requiring emergent surgical intervention. During 1 year, the patient was readmitted four times due to poor oral intake, dehydration and abdominal distention. Investigation revealed partial small bowel volvulus which resolved with non-operative treatment. Small and large bowel volvulus are uncommon and life-threatening gastrointestinal manifestations of ATR-X patients, which may contribute to the common phenomenon of prolonged food refusal in these patients.
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PMID:Volvulus and bowel obstruction in ATR-X syndrome-clinical report and review of literature. 2617 13

We report a 47-year-old man who underwent endoscopic gastrostomy placement due to feeding refusal and regurgitation. Procedure was unremarkable. Two days later, the patient presented signs of intestinal obstruction. Computed tomography imaging showed a well-positioned gastrostomy tube, small pneumoperitoneum, and small bowel volvulus (SBV) in the upper right abdomen with proximal small bowel dilated loops. Exploratory laparotomy revealed mesenteric torsion, leading to SBV, with no evidence of intestinal malrotation. Volvulus was successfully untwisted via surgery. This case highlights to the possible association between SBV and gastrostomy placement.
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PMID:Midgut Volvulus after Percutaneous Endoscopic Gastrostomy. 2845 83

Chronic gastric instability (CGI) is part of the gastric dilatation and volvulus (GDV) complex and contributes to the pathophysiologic mechanism of volvulus. Clinical signs can be attributed to a flaccid and mobile stomach. This manuscript reviews the literature regarding CGI and presents a case where computerized tomography is utilized in combination with abdominal radiography to diagnose CGI in an 8 year old spayed female Great Dane. The patient presented for nonspecific clinical signs including hypersalivation, anorexia, and regurgitation, and was euthanized after failing medical management and developing acute abdominal pain. Necropsy revealed a distended stomach with 180o rotation along its long axis. This case demonstrates that CGI and GDV share a continuum, and cases of CGI may progress to GDV without prophylactic surgical intervention.
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PMID:Diagnosis of chronic gastric instability using computed tomography in a Great Dane that progressed to gastric dilatation and volvulus: a literature review and case report. 3042 56


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