Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042961 (volvulus)
 4,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The diagnostic potential of musculo-skeletal pain (MSP) in the rapid assessment of onchocerciasis of morbidity and of the impact of ivermectin treatment in a community is brought to picture. The clinical impression is that MSP is a common, early, chronic important symptom of onchocerciasis. With a significant association with onchocerciasis, MSP has the potential of being an important operational diagnostic clue in the detection of onchocerciasis. It has the advantage of being easily recognizable, and therefore can be applied by primary health care workers. MPS is proved to cause the greatest morbidity, particularly among working farmers in areas where the forest strain of O. volvulus is predominant. Thus, onchocerciasis is contributing more than was perhaps realized to the reduced output of work from farmers. However, MPS, a parasitic rheumatism, is proved to be eminently susceptible to treatment by DEC.
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PMID:Musculo-skeletal pain (MSP) in onchocerciasis: a potential in the rapid low cost epidemiological survey and in the assessment of impact of ivermectin treatment on a community. 141 18

Onchocerciasis or "river blindness" is a vector-borne tropical disease resulting from infection with the filarial nematode Onchocerca volvulus. Disease manifestations include dermatitis, rheumatic complaints, and blindness. Recent findings have suggested an autoimmune etiology for the occurrence of chorioretinopathy, a disease of the eye which together with sclerosing keratoconjunctivitis is responsible for approximately 400,000 onchocerciasis-related cases of blindness. The identification of onchocerciasis as an important cause of tropical rheumatism prompted us to evaluate serologically the presence of systemic autoimmune disease in onchocerciasis patients and local controls from a hyperendemic area in Sierra Leone. In both groups there was a marked autoimmune response against cytoplasmic non-RNA-associated proteins consisting of autoantibodies against five major Ag with respective m.w. of 35, 51, 64, 83, and 110 kDa. These five proteins are novel autoantigens that could be distinguished from calreticulin, the human homologue of the onchocercal Ag RAL-1, and known autoantigens such as the 50-kDa La/SS-B or 52- and 60-kDa Ro/SS-A proteins by immunoblotting and ELISA assays. Furthermore, autoantibody reactivity against calreticulin was significantly higher in O. volvulus-infected individuals than in endemic controls. Autoantibody reactivity against the five major autoantigens, anti-calreticulin reactivity, and antibody reactivity against the 65-kDa arthritis-associated mycobacterial heat shock protein were intercorrelated as parts of an onchocerciasis-associated autoimmune response. The implication of autoimmunity in the disease pathogenesis of onchocerciasis could have important consequences for future research on therapeutical regimens, pathogenetic mechanisms, and serological diagnosis of onchocerciasis.
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PMID:Autoimmunity and filariasis. Autoantibodies against cytoplasmic cellular proteins in sera of patients with onchocerciasis. 790 Dec 81