Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042961 (volvulus)
 4,305 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over a 7 year period, intestinal obstruction accounted for 41.7 per cent of abdominal emergencies and 1.03 per cent of all paediatric admissions at the Obafemi Awolowo University Teaching Hospital in Ile-Ife, Nigeria. Of the total 76 cases of acute intestinal obstruction, intussuception was seen in 34 (44.7%), peritoneal adhesions in 17 (22.4%), obstructed hernia in 14 (18.4%), roundworm impaction in 4 (5.3%), volvulus in 3 (4.0%) while faecal impaction and mesenteric cysts were encountered in 2 children each (2.6%). Generally the patients presented late to the hospital and this accounted for the high post-operative morbidity and prolonged hospital stay. Wound infection occurred in 21.1 per cent of patients and formed the commonest post-operative complication. The overall mortality was 21.1 per cent.
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PMID:Acute intestinal obstruction in Nigerian children. 271 54

Nematode infections of the eye are common in different parts of the world, but some are usually encountered only in developing nations, such as onchocerciasis and cysticercosis. Ocular toxocariasis is a well-known cause of unilateral ocular disease affecting mainly children and young adults, and is usually caused by T canis. Prevention of ocular toxocariasis is based on such measures as appropriate health care for dogs and cats, including regular anthelmintic treatments, preventing contamination of the environment with feces, and promoting responsible pet ownership [1,49-51]. Onchocerciasis is caused by infection with the filarial parasite O volvulus, and occurs in endemic areas along rivers and streams. In hyperendemic areas almost every person is infected and about half of the population is eventually blinded by onchocerciasis. Because of this, elimination of host-vector contact is very important. DUSN is caused by a motile nematode and is found in the Southeastern and Midwestern United States and in many parts of the world. In Brazil, DUSN is becoming an important cause of posterior uveitis in children and young healthy adults. The destruction of the worm during the early stages of the disease can prevent progression of the visual loss. It is important to remain aware of this entity, not only in areas where it has been described, but also in regions not yet identified as being endemic [52]. Cysticercosis is caused by the encystment of the larvae of the tapeworm T solium, and usually results from ingesting eggs from food, water, or other material contaminated with human feces. Surgical removal of the cyst is usually indicated when possible.
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PMID:Nematode infections of the eye: toxocariasis, onchocerciasis, diffuse unilateral subacute neuroretinitis, and cysticercosis. 1243 84

Onchocerciasis, also known as river blindness, is the second leading infectious cause of blindness worldwide. In order to successfully control this disease, the development of efficient diagnostic tools as well as effective treatments is imperative. A number of proteins have been proposed as vaccine and diagnostic candidates, yet none have been successfully advanced to the point of general clinical use. We have prepared major sperm protein 2 (MSP2) from Onchocerca volvulus as a possible diagnostic antigen for onchocerciasis. Importantly, recombinant MSP2 is dimeric in solution, identical to alpha-MSP from the roundworm, Ascaris suum. A panel of sera obtained from Cameroonian individuals afflicted with onchocerciasis positively responded to the recombinant MSP2. Our data suggest that MSP2, like the previously described antigen Ov16, can be utilized as a diagnostic onchocerciasis antigen for monitoring the interruption of transmission.
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PMID:Major sperm protein as a diagnostic antigen for onchocerciasis. 1863 76

Filariases are diseases caused by infection with filarial nematodes and transmitted by insect vectors. The filarial roundworm Dirofilaria immitis causes heartworm disease in dogs and other carnivores. D. immitis is closely related to Onchocerca volvulus, Wuchereria bancrofti and Brugia malayi, which cause onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) in humans and are neglected tropical diseases. Serum N-glycosylation is very sensitive to both pathological infections and changes in mammalian biology due to normal aging or lifestyle choices. Here, we report significant changes in the serum N-glycosylation profiles of dogs infected with D. immitis. Our data derive from analysis of serum from dogs with established patent infections and from a longitudinal infection study. Overall, galactosylation and core fucosylation increase, while sialylation decreases in infected dog sera. We also identify individual glycan structures that change significantly in their relative abundance during infection. Notably, the abundance of the most dominant N-glycan in canine serum (biantennary, disialylated A2G2S2) decreases by over 10 percentage points during the first 6 months of infection in each dog analyzed. This is the first longitudinal study linking changes in mammalian serum N-glycome to progression of a parasitic infection.
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PMID:Changes in canine serum N-glycosylation as a result of infection with the heartworm parasite Dirofilaria immitis. 3041 44