Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042875 (vitamin E deficiency)
 916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lipofuscin in the retinal pigment epithelium (RPE) is thought to be derived from phagocytosed photoreceptor outer segment disc membranes. Based on this hypothesis, one would predict that the rate of lipofuscin deposition in the RPE would be proportional to the density of photoreceptor cells in the retina. In previous studies it was demonstrated that specific loss of photoreceptor cells due to a genetic defect resulted in a substantial decrease in the rate of age-related lipofuscin accumulation in the RPE. In order to confirm that this decreased RPE lipofuscin deposition was directly related to reduced photoreceptor cell density, experiments were conducted to determine whether light-induced photoreceptor cell destruction affected RPE lipofuscin content. The effects of retinal light damage on RPE autofluorescent pigment accumulation resulting from both normal aging and vitamin E deficiency were examined. Starting immediately after weaning, albino Fisher 344 rats were fed diets either containing or lacking vitamin E. All animals were maintained on a 12 hr/12 hr light/dark cycle. During the light phases of the cycles, the cage illuminance for one-half the animals in each dietary group was 750 lux, while the remaining rats were exposed to a light level of 15 lux. Illumination was provided by 40 watt cool-white fluorescent lamps. After 17 weeks, rats in both dietary groups that were maintained under the higher light intensity had substantially reduced photoreceptor cell densities relative to animals in the same dietary group maintained under dim light conditions.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium. 291 13

It has been demonstrated that vitamin E deficiency from birth increases anxiety-related behavior using knockout animals with no vitamin E transfer proteins. The current study was undertaken to elucidate the effect of dietary vitamin E deficiency on anxiety-related behavior of rats in different housing conditions. Male Wistar strain rats were divided into two groups during the weaning period and fed a control or vitamin E-deficient diet. All rats were housed in groups (three rats per cage) for 3 weeks. In the fourth week, half of the rats in each dietary treatment were kept in social housing and the other half were kept in individual housing. Before sacrifice, rota-rod and elevated plus-maze (EPM) tests were performed to measure motor coordination and anxiety, respectively. The EPM test revealed that vitamin E-deficient rats spent less time in the open arms and showed more stretch-out posture than the control rats, showing that anxiety increased with dietary vitamin E deficiency. Furthermore, vitamin E deficiency-induced anxiety behavior was observed more prominent in individual housed rats than in social housed rats. On the basis of these results, we conclude that dietary vitamin E deficiency induces anxiety in rats especially under stress of social isolation.
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PMID:Dietary vitamin E deficiency increases anxiety-related behavior in rats under stress of social isolation. 1947 64