Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042875 (
vitamin E deficiency
)
916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Vitamin E deficiency
causes a neurological disorder characterised by sensory loss, ataxia and retinitis pigmentosa due to free radical mediated neuronal damage. Symptomatic
vitamin E deficiency
has been reported in genetic defects of the vitamin E transport protein and in malabsorption complicating cholestasis, abetalipoproteinaemia, celiac disease, cystic fibrosis and small bowel resection. There are no reports to date of
vitamin E deficiency
in patients with primary immunodeficiencies. We describe two
CVID
patients with the associated enteropathy who developed neurological disease because of
vitamin E deficiency
, suggesting a possible predisposition to developing this complication. We recommend that all
CVID
patients with evidence of an enteropathy be screened for
vitamin E deficiency
, as early detection and consequent treatment may prevent, halt or reverse the neurological sequelae.
...
PMID:Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. 1520 78
