Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042875 (vitamin E deficiency)
 916 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In three trials pigs were fed semisynthetic diet characterized by vitamin E deficit and supplemented with lard at different degrees of oxidative rancidity. When rancid lard was used and pigs were exposed to the effects of stress factors from the 55th day of the trail, signs of affected walking and lack of appetite were observed. Pig organs were subject to histological examination on the 83rd day. Dystrophic changes of heart and skeletal muscles were revealed. The changes were accompanied by increased activities of aspartate and alanine amino transferases and lactate dehydrogenase in blood serum. The addition of 150 mg of tocopherol acetate per 1 kg of feed increased its concentration in tissues and prevented the occurrence of clinical, biochemical, and morphological signs; decreases in weight gains were also avoided. When fresh fat was used without any additional effect of stress factors, no morphological signs of vitamin E deficiency were observed. A decreased quality of lard in feed was not found to exert any influence on a higher consumption of vitamin E. The production of lipoperoxides in tissue homogenates was considerably decreased as a result of the addition of vitamin E to feed. The criteria to be used for intravital and post-mortal diagnosis of vitamin E deficiency in pigs are evaluated.
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PMID:[Effect of experimental lard diet on the incidence of vitamin E deficiency signs in pigs]. 81 48