Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042875 (
vitamin E deficiency
)
916
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The ultrastructural and erythrokinetic characteristics of
vitamin E deficiency
in swine were investigated in an effort to evaluate the suitability of the swine disorder as a model of the human congenital dyserythropoietic anemias. The dominant erythrokinetic abnormality in vitamin E deficient pigs, as in the CDAs, is ineffective erythropoiesis. As in some patients with
CDA
, the activity of a number of erythrocyte enzymes was increased. Distinctive ultrastructual changes previously described in patients with
CDA
were found in normoblasts from vitamin E deficient pigs. The morphologic, erythrokinetic, biochemical and ultrastructural similarities between
vitamin E deficiency
in swine and the CDAs in man appear to justify the study of the animal disorder as a model of the human disease. A complete hematologic response was elicited by the administration not only of vitamin E, but also, as in the previous studies of
vitamin E deficiency
in monkeys, by hexahydrocoenzyme Q4. The partial hematologic response occurring after deletion of tocopherol stripped corn oil from the diet indicates that factors other than the dietary lack of vitamin E are important in the pathogenesis of this disorder.
...
PMID:The anemia of vitamin E deficiency in swine: an experimental model of the human congenital dyserythropoietic anemias. 88 23
