Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042755 (
masculinization
)
2,562
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The role of sex steroids in the programming of the level of serum
corticosteroid binding globulin
(
CBG
) of male and female rats has been studied at different stages of ontogenesis. It was shown that castration of adult males lead to the increase of the level of
CBG
, but not to the elimination of sex differences. Gonadectomy of males up to 28th day of postnatal life results in complete feminization of the
CBG
content in these animals at the age of 10-12 weeks. The castration after 35th day of life does not prevent the formation of the male phenotype of
CBG
content. The results of administration of testosterone-propionate (TP) to castrated males at different periods of ontogenesis suggests that the sensitivity to irreversible negative action of androgens appears after 28th day of life and disappears after the puberty. It was concluded that short period of ontogenesis from 29th to 35th days of life is critical for the realization of the irreversible
masculinization
of
CBG
level upon the influence of androgens in the physiological conditions. It was found that injections of both synthetic estrogens diethylstilbestrol or TP in the sensitive period of ontogenesis lead to the expression of male phenotype of
CBG
level in a similar fashion.
...
PMID:[The characteristics of the programming action of androgens on the formation of sexual dimorphism in the level of corticosteroid-binding globulin in rats]. 185 67
