Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0042755 (
masculinization
)
2,562
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of pinealectomy (PX) and sham-pinealectomy (SPX) on the calculated concentration of NaCl in the total volume of fluid drunk per day ([NaCl]I) in female rats offered a free choice between water and 3% NaCl solution was measured. In normal rats the [NaCl]I increases after attainment of sexual maturity. The increase can be accelerated by neonatal PX. Neonatal '
masculinization
' of female rats by testosterone propionate (
TP2
) removes the increase of [NaCl]I in adult females and suppresses the acceleration due to PX. Neonatal SPX interferes with this decreasing effect of
TP2
in adult female rats. The role of the pineal gland in the regulation of water and salt intake is discussed in relation to sex differences, sexual maturation and neonatal stress.
...
PMID:The pineal gland and the effect of neonatal administration of androgen upon the development of spontaneous salt and water intake in female rats. 116 47
