Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042755 (masculinization)
 2,562 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several recent reports have linked the use of estrogenic and progestational hormones during pregnancy with an increased incidence of birth defects. Progestational agents may cause virilization of the female fetus. Female children, exposed in utero to diethylstilbestrol, have been shown to develop a higher incidence of vaginal cancer than others. Use of oral medication to diagnose a pregnancy has been linked to neural tube malformations. Most investigations linking sex hormones with birth defects have been retrospective and may be biased by the fact that parents of children with congenital malformations are more likely to have remembered and reported use of drugs during pregnancy. In an analysis of 50,282 pregnancies for drug ingestion, suggestive evidence was found in 2277 for a relationship between maternal exposure and congenital malformations. It is recommended that the use of withdrawal-type pregnancy tests be abandoned. The use of progestational agents as prophylactic treatment for therapeutic abortion should be discontinued. Prior to use of any sex hormone, it should be determined that the patient is not pregnant. Those who become pregnant while inadvertently using sex hormones should discontinue the use and be advised of the possibility of an increased incidence of congenital malformations. However, the possible increased risk is relatively low.
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PMID:Sex hormones and congenital malformations: a review. 86 46