Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Bithermal caloric stimulation in a patient with a benign paroxysmal positioning vertigo of the horizontal (lateral) semicircular canal (HC-BPPV) revealed a significant hypoexcitability of the affected ear that was reversible when treated by liberatory maneuvers. Both the positional vertigo and caloric hypoexcitability in HC-BPPV are caused by canalolithiasis, a concept strongly supported by the intensity of the positioning nystagmus being maximal when the patient turned his head around the longitudinal z-axis from the left lateral to right lateral position while recumbent (maximum slow-phase velocity [SPV] 176 deg/sec) and being much lower (maximum SPV 55 deg/sec) when he turned his head to the right lateral position while in a supine position (nose up). The dependence of this difference in nystagmus intensity on the initial head position and direction of rotation indirectly proves that the clot moves freely (to and fro) within the segment of the HC diametrically opposite to the ampulla. The reversibility of ipsilateral caloric hypoexcitability is attributed to the clot's (functional) plugging of the HC, which agrees with studies in squirrel monkeys. These data support the view that physiologic caloric responses consist of a major convective and minor nonconvective component.
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PMID:Horizontal canal benign paroxysmal positioning vertigo: reversible ipsilateral caloric hypoexcitability caused by canalolithiasis? 750 Nov 61

Sudden sensorineural hearing loss is usually unilateral, and the cause is not identified in most adult cases. However, a specific cause has frequently been found in the case of children, in whom idiopathic sudden sensorineural hearing loss (ISHL) is comparatively rare. We investigated 20 cases of acute unilateral sensorineural hearing loss in children associated with a certain disease, but which was first diagnosed as ISHL. Thirteen patients aged 6 to 16 years old were diagnosed as having psychogenic (functional) hearing loss. Discrepancies in behavioral and objective tests are most valuable when functional hearing loss is suspected. Elevated pure-tone thresholds associated with normal distortion product otoacoustic emissions (DPOAEs) enable prompt further investigation. There are several conditions that may mimic functional hearing loss, so auditory brainstem response (ABR) testing is necessary to verify the actual cause. The unilateral profound hearing loss in 2 patients aged 7 and 11 years old was due to asymptomatic mumps proven by detecting the mumps IgM antibody. Total hearing recovery in the 125-1000 Hz frequencies occurred in one case. In 5 patients aged 6 to 12 years old with acute hearing loss and vertigo, high resolution CT imaging showed an abnormally enlarged vestibular aqueduct on the affected side. Large vestibular aqueduct syndrome should be considered in acute high-frequency sloping hearing loss with an A-B gap at low frequencies.
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PMID:[Clinical features associated with sudden hearing loss in children]. 2299 53