Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A possible involvement of the VIII cranial nerve in Multiple Sklerosis was investigated. 15 of the 135 MS-patients were tested by evoked response audiometry (ERA) and vestibular examinations. Only a central nystagmus, central vertigo and coordination disorder were seen. Lesions of the peripheral vestibular system and pathological data of the evoked response audiometry were not found.
 ...
PMID:[Evoked response audiometry and vestibular examinations in patients with multiple sclerosis (author's transl)]. 13 57

A clinical and pathological study of carcinomatous encephalomyelitis is presented. Attention is drawn to the various types of nonmetastatic paraneoplastic syndromes and their particular association with oat cell carcinoma of the lung. The feature of special interest in this study is the onset with otologic symptoms, sudden deafness in the left ear and vertigo, at a time when the neoplastic basis for the disease was not clinically evident. The most striking change in the left temporal bone is the almost total loss of cochlear neurons in Rosenthal's canal and degeneration of both divisions of the vestibular nerve. The organ of Corti and stria vascularis are normal throughout the cochlear duct. The vestibular sense organs are normal. The left cochlear nucleus is devoid of neurons, this neuronal loss is accompanied by a well developed astrocytic and microglial response similar to that in the medulla and spinal cord. This represents a carcinomatous sensory neuropathy involving the left VIII nerve with simultaneous involvement of the left cochlear nucleus. The pathogenesis of this condition still defies explanation, but there are some insights in the autoimmune sector.
 ...
PMID:Carcinomatous encephalomyelitis with auditory and vestibular manifestations. 17 18

Vestibular neurectomy technique used for the standard middle fossa approach and for a total translabyrithine VIII nerve section is described. The middle fossa approach has been used in 49 cases of mainly Meniere's disease and basically the same approach for nerve decompression has been used in 19 cases of facial paralysis, 15 being due to Bell's palsy, 2 to petrous pyramid cholesteatoma and 2 to facial nerve Schwannoma. In unilateral Meniere's disease with no further function in hearing, vestibular neurectomy gives good results in alleviating vertigo.
 ...
PMID:Vestibular neurectomy. 28 51

The clinical findings in 125 patients with surgically confirmed acoustic neuromas are presented, with special regard to the involvement of the intermedius nerve in the diagnosis. In assessing the function of the intermedius nerve the examination of the nasolacrimal reflex and the sensation of taste on the anterior two-thirds of the tongue are used. The methods of investigation are described in detail. The material consisted of 20 medium-sized and 105 large tumours; no intracanalicular tumor was found. Hearing loss was the initial symptom in 85% of the patients, 10% had tinitus and 4% vertigo as the first symptom. Apart from the VIII cranial nerve symptoms, a defective nasolacrimal reflex was the most significant evidence of cerebellopontine angle pathology. The test was positive in 65% of the medium-sized tumours, in the entire material, 85%. The figures are higher than the incidence of trigeminal nerve symptoms. This in contrast to the reports of most authors. The tests described are simple and quick to perform, and it is emphasized that they should be applied to all patients with unilateral hearing loss of unknown origin.
 ...
PMID:Intermedius nerve involvement and testing in acoustic neuromas. 118 41

An anamnesis model for management patient with vertigo or dizziness caused by disturbance of vestibular system were presented. Data were sorted in eight axis: Axis I (symptoms), Axis II (physical examination), Axis III (electrophysiological findings), Axis IV (associate pathology), Axis V (laboratory tests), Axis VI (psychosocial), Axis VII (therapeutic response) and Axis VIII (familiar antecedents).
 ...
PMID:[The anamnesis as a global strategy with the vestibular patient. A model presentation]. 158 Oct 89

A malfunctioning orbital flight attitude thruster during the flight of Gemini VIII led to acceleration forces on astronauts Neil Armstrong (commander) and David Scott (pilot) that created the potential for derogation of oculo-vestibular and eye-hand coordination effects. The spacecraft attained an axial tumbling rotation of 50 rpm and would have exceeded this had not the commander accurately diagnosed the problem and taken immediate corrective action. By the time counter-measure controls were applied, both astronauts were experiencing vertigo and the physiological effects of the tumbling acceleration. Data from the recorders reveal that one astronaut experienced -Gy of 0.92 G-units, and the other +Gy of 0.92 for approximately 46 s. Both received a -Gz of 0.89 G-units from the waist up with a +Gz of 0.05 from the waist down. A substantial increase of time and/or an increase in rpm would ultimately have produced incapacitation of both astronauts. NASA corrected the Gemini thruster problem by changing the ignition system wiring. Future space-craft undertaking long-term missions could be equipped with unambiguous thruster fault displays and could have computer-controlled automatic cutoffs to control excessive thruster burns.
 ...
PMID:Tumbling and spaceflight: the Gemini VIII experience. 230 30

As I have indicated in the foregoing discussion, there are several syndromes that with various degrees of proof seem to be caused by unilateral vascular compression of a cranial nerve at the brain stem. Jannetta has summarized this concept as follows: "As we age, our arteries elongate and our brains 'sag'. As a consequence of these processes, redundant arterial loops and bridging or intrinsic hindbrain veins may cause cross-compression of cranial nerve root entry zones in the cerebellopontine angle. This pulsatile compression can be seen to produce hyperactive dysfunction of the cranial nerve. Symptoms of trigeminal or glossopharyngeal neuralgia (somatic sensory), hemifacial spasm (somatic motor), tinnitus and vertigo (special sensory), and some cases of 'essential' hypertension are caused by these vessels compressing cranial nerves V, IX-X, VII, VIII, and left X and medulla oblongata. Using microsurgical techniques, the symptoms may be relieved by vascular decompression. . .".
 ...
PMID:Neurovascular compression syndromes. 389 20

As we age, our arteries elongate and our brains "sag." As a consequence of these processes, redundant arterial loops and bridging or intrinsic hindbrain veins may cause cross-compression of cranial nerve root entry zones in the cerebellopontine angle. This pulsatile compression can be seen to produce hyperactive dysfunction of the cranial nerve. Symptoms of trigeminal or glossopharyngeal neuralgia (somatic sensory), hemifacial spasm (somatic motor), tinnitus and vertigo (special sensory) and some cases of "essential" hypertension are caused by these vessels compressing cranial nerves V, IX--X, VII, VIII, and left X and medulla oblongata. Using microsurgical techniques, the symptoms may be relieved by vascular decompression, findings and results in 695 paients are briefly reviewed and correlated. A chronic primate model of "essential" hypertension is briefly described.
 ...
PMID:Neurovascular compression in cranial nerve and systemic disease. 696 43

Eight patients with severe peripheral vestibular vertigo refractory to other drug and surgical treatments underwent intracranial ligation of the vestibular nerve VIII portion. All the patients had been operated on the middle and internal ears many times (from 12 to 15 operations) for chronic purulent otitis (5 patients), cholesteatomas, 2-3 attempts had been made to destruct the labyrinth; shunting of the endolymphatic sac was made 2-3 times in patients with Meniere's disease. In all the patients, severe peripheral vestibular syndrome was associated with central nervous disease, mainly formations of the cerebellopontile angle due to secondary arachnoiditis. After ligation of the vestibular nerve VIII portion, good results were achieved in 7 out of the 8 patients, but one had a satisfactory effect. The paper shows indications and contraindications for intracranial ligation of the vestibular nerve VIII portion. It also emphasizes that the operation is effective, but it should be effected by very strict and limited indications when all other treatments are ineffective and vertigo is critical.
 ...
PMID:[The treatment of severe peripheral vertigo by the intracranial ligation of the vestibular portion of the 8th nerve]. 829 10

A 49-year-old female presented with an extremely rare lipoma of the cerebellopontine angle (CPA) manifesting as intractable vertigo and tinnitus. Subtotal removal of the lipoma was performed to debulk the tumor and decompress the cranial nerve VIII. Her complaints were resolved without new neurological deficit. We recommended surgery in patients with symptomatic CPA lipomas for diagnosis, debulking, and decompression of cranial nerves to relieve the symptoms.
 ...
PMID:Eighth cranial nerve lipoma manifesting as intractable vertigo--Case report. 865 34


1 2 3 4 5 Next >>