Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The middle components of the auditory evoked response (middle latency response, MLR) were evoked by acoustic clicks from the normal-hearing ear and by charge-balanced biphasic current pulses from the severe-to-profoundly hearing-impaired ears of patients undergoing labyrinthectomy for the management of intractable vertigo. A vertex-positive peak with a latency ranging from 27 msec to 38 msec (Pa) was characteristic of both the electric and the acoustic MLR. In subjects, the electric Pa always preceded the acoustic Pa in latency. In addition, the electric Pa had a sharper appearance than did the acoustic Pa. The electric MLRs were elicited by a range of stimulus intensities and persisted after the completion of labyrinthectomy.
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PMID:An intrasubject comparison of electric and acoustic middle latency responses. 252 65

Fhar's disease is a rare idiopathic CNS pathology characterized by widespread calcifications of the basal ganglia, cerebellar nuclei and endocranial vessels. The origin of this disease is unknown and a lack of thyroid and parathyroid pathologies is the main statement. From the clinical point of view, extrapyramidal manifestations are common while vertigo and equilibrium disorders are rare. In the present case vertigo and disequilibrium were the main symptoms. Fhar's disease was diagnosed by CT and MRI showing calcification of the basal ganglia without any metabolism disorders or thyroid and parathyroid pathology. A battery of neurotological tests showed alterations of VOR and ocular movement. In particular the saccades movements showed significant hypometria while the smooth-pursuit showed gain diminution and corrective saccades. These anomalies imply dysfunction of sub-cortical centers regulating and modulating ocular movement. VOR alterations included both qualitative anomalies of nystagmus (i.e. dysrhythmia, square waves) and quantitative alterations (i.e. bilateral deficit response to caloric and rotatory stimuli). These alterations could be due to the impairment of cerebellum-vestibular and vestibular-thalamic pathways. Acoustic evoked potentials (ABR, MLR) ruled out central acoustic pathway dysfunction.
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PMID:[Otoneurological manifestations in Fhar's disease. A case report]. 965 29