Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histologic and ultrastructural findings in the temporal bones of a patient clinically diagnosed as having unilateral Meniere's disease are presented. The patient underwent two endolymphatic subarachnoid shunt operations that failed to relieve symptoms and a middle fossa vestibular nerve section that completely relieved episodic vertigo and stabilized hearing in the ear operated upon. Histopathologic examination of the temporal bones showed no endolymphatic hydrops in either ear. The maculae and cristae on the side operated upon showed severe degenerative changes attributed to vestibular neurectomy. The cochleograms of the operated and contralateral ears showed degeneration of the sensorineural structures in the basal two turns of the cochlea. No apparent cause for the fluctuant hearing loss was found in the cochlea or the cochlear nerve of the involved ear. Light and electron microscopic studies of the vestibular nerve excised at the time of vestibular neurectomy showed that most of the nerve fibers and ganglion cells were essentially normal. Collagen tissue deposition was increased in some areas of the endoneurial space. Most myelinated nerve fibers in these areas had degenerated. Although these changes may be partly due to artifacts and partly due to aging, they probably are the result of a pathologic process affecting the vestibular nerve. These findings suggest that a revised approach to the etiology, pathogenesis, and treatment of Meniere's symptom complex is indicated.
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PMID:Pathologic significance of Meniere's symptom complex. A histopathologic and electron microscopic study. 744 48

Meshes of collagen and/or elastin were successfully prepared by means of electrospinning from aqueous solutions. Flow rate, applied electric field, collecting distance and composition of the starting solutions determined the morphology of the obtained fibres. Addition of PEO (M(w)=8 x 10(6)) and NaCl was always necessary to spin continuous and homogeneous fibres. Spinning a mixture of collagen and elastin resulted in fibres in which the single components could not be distinguished by SEM. Increasing the elastin content determined an increase in fibres diameters from 220 to 600 nm. The voltage necessary for a continuous production of fibres was dependent on the composition of the starting solution, but always between 10 and 25 kV. Under these conditions, non-woven meshes could be formed and a partial orientation of the fibres constituting the mesh was obtained by using a rotating tubular mandrel as collector. Collagen/elastin (1:1) meshes were stabilized by crosslinking with N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). This treatment afforded materials with a high thermal stability (T(d)=79 degrees C) without altering their original morphology. Upon crosslinking PEO and NaCl were fully leached out. Smooth muscle cells grew as a confluent layer on top of the crosslinked meshes after 14 d of culture.
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PMID:Electrospinning of collagen and elastin for tissue engineering applications. 1611 44