Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

4 women aged 30-34 years were given the luteinizing hormone-releasing hormone (LH-RH) analog D-Ser(TBU6-EA10-LRH to determine its effects on the pituitary response. 5 mcg/day analog were self-administered sc for 22-30 days beginning within the first 3 days of menstrual bleeding, and serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, and progesterone were monitored 3 times weekly. In all 4 subjects there was a sharp rise in LH and FSH on Treatment Day 1 that fell to within lower normal follicular phase limits for the remainder of treatment. Estradiol and progesterone responses varied among the subjects, perhaps because premature bleeding caused 2 subjects to begin treatment at a different point in the menstrual cycle. 1 subject stopped treatment after Day 22 because of headache and vertigo. None of the women ovulated during treatment, but 3 of 4 had ovulated within 4 weeks of discontinuation of treatment, and all women ovulated in the following cycle. The anovulatory effect of the analog is thought to be due to a disturbance of pituitary gonadotropin secretion that leads in turn to disordered follicle development. The possibilities for using this analog as a means of birth control are discussed.
 ...
PMID:Inhibition of ovulation in women by chronic treatment with a stimulatory LRH analogue--a new approach to birth control? 35 12