Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 810 parasitologically examined persons (1981) 277 (34%) showed positive findings. The high percentage of parasitisation in foreigners (86%) is to be explained by the in most cases aimed transfer of these patients (215 of the 810 persons). Affection with Schistosoma was recognized in 51 patients at the age of 17-47 years (means = 21.86), without Africans, and stood in the 3rd place of the distribution of frequency of the heterogeneous parasitoses. 49 of these patients came from Mozambique, 1 from Namibia and 1 from Zambia. In 51% S. haematobium was diagnosed, in 22% S. mansoni and in 27% a double infestation with the two forms of parasites. While 80% of the patients with affection of S. haematobium showed clinical symptoms (macrohaematuria, cystitis complaints), there were only 44% among the S. mansoni group. 47 patients were treated with Niridazole (Ambilhar, 25 mg/kg, 5-7 days), 2 patients with Praziquantel (Biltricide, 40 mg/kg, 1 day) and 2 other patients with Praziquantel after unsuccessful Niridazole therapy. Follow-up examinations were performed after 1, 3, 6 and 12 months. In 17% of the patients treated with Niridazole the primary treatment did not lead to cure; side effects (abdominal pain, nausea, vertigo) were observed in 55%. Praziquantel was tolerated very well. During a control period of 1 year living eggs of Schistosoma were no more proved.
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PMID:[Clinical aspects and therapy of schistosomiasis]. 661 96

41 patients (20 females and 21 males aged from 8 to 68 years) were prescribed 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one(praziquantel, EMBAY 8440, Biltricide) at a dose of 25 mg/kg body weight given three times on a single day at intervals of 4 h, for the treatment of opisthorchiasis. Clinical as well as biological tolerance was followed up very closely, first during a hospitalization period of 6 days, then on day 20, 40, 90 or more after treatment. None of the biological controls consisting of a total of 47 parameters (haematological, biochemical, urinary) showed any variation from before to after treatment. Clinical examinations, recorded in very carefully prepared case report sheets, served for systematically screening general signs and symptoms (fever, headache, etc.), digestive manifestations or neurological signs. Tolerability was absolutely perfect in 10 patients. In the remaining 31 cases the following signs were observed: lassitude or vertigo (15 times), headache (14 times), drowsiness and nausea (5 times), epigastric pain (9 times), arthralgia-myalgia (3 times), sweating (1 time). All these signs lasted one or two days only and were of weak or moderate intensity, thus allowing the conclusion that even at higher dosages tolerability to praziquantel is excellent.
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PMID:[Study on the tolerability of high doses of praziquantel in Laotians with parasitic liver infections (author's transl)]. 719 55