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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Benign positional vertigo, the most common cause of vertigo, can now be cured with a simple bedside maneuver. A series of recent publications have clarified the pathophysiology of benign positional vertigo and documented the efficacy of particle repositioning maneuvers for treating the condition. The number of genetic loci and abnormal genes associated with inherited auditory and vestibular disorders is rapidly expanding. Within the past years, genes have been identified for Usher syndrome, Alport syndrome, deafness with fixation of the stapes and familial periodic ataxia. These discoveries should lead to improved diagnosis and, eventually, specific treatments for these disorders.
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PMID:Vestibular and auditory disorders. 872 61

Alport syndrome (AS) is caused by mutations in collagen IV, which is widespread in the basement membranes of many organs, including the kidneys, eyes, and ears. Whereas the effects of collagen IV changes in the cochlea are well known, no changes have been described in the posterior labyrinth. The aim of this study was to investigate both the auditory and the vestibular function of a group of individuals with AS. Seventeen patients, aged 9-52, underwent audiological tests including pure-tone and speech audiometry, immittance test and otoacoustic emissions and vestibular tests including video head impulse test, rotatory test, and vestibular evoked myogenic potentials. Hearing loss affected 25% of the males and 27.3% of the females with X-linked AS. It was sensorineural with a cochlear localization and a variable severity. 50% of the males and 45.4% of the females had a hearing impairment in the high-frequency range. Otoacoustic emissions were absent in about one-third of the individuals. A peripheral vestibular dysfunction was present in 75% of the males and 45.4% of the females, with no complaints of vertigo or dizziness. The vestibular impairment was compensated and the vestibulo-ocular reflex asymmetry was more evident in rotatory tests carried out at lower than higher speeds; a vestibular hypofunction was present in all hearing impaired ears although it was also found in subjects with normal hearing. A posterior labyrinth injury should be hypothesized in AS even when the patient does not manifest hearing disorders or evident signs of renal failure.
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PMID:Vestibular and audiological findings in the Alport syndrome. 3282 May 99