Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute hearing loss in an early stage of syphilis was frequently seen in the 19th century, but is very rare nowadays. One historical and one recent case of untreated syphilis are reported. Based on studies of the diary of the Czech composer Fr. Smetana the history of his disease is presented. Following an angina, which had lasted for several weeks, a profuse exanthema developed about 16 weeks after the primary infection. Two weeks later ear symptoms with hearing disorder, tinnitus and vertigo began, resulting in total bilateral deafness after some weeks. Exitus 10 years later by taboparalysis. The recent case is a 25 year old male subject. Also following a longstanding angina a profuse exanthema appeared about 8 weeks after the primary infection. Ear symptoms, hearing disorder and tinnitus in one ear, developed one week after onset of the exanthema. By immediate specific treatment a fateful cours like that of Smetana's could be prevented.
 ...
PMID:[Acute hearing loss in the early stage of acquired syphilis. A historical and a new case]. 351 40

The experience at the Mayo Clinic with 18 patients who had Cogan's syndrome is reviewed. Typically, the illness began with systemic symptoms. The ocular and audiovestibular symptoms included ocular discomfort and redness, photophobia, and fluctuating sensorineural deafness with imbalance. Each patient had interstitial keratitis; the ocular symptoms periodically recurred but responded to therapy. Thirteen patients who had fluctuating bilateral sensorineural deafness subsequently suffered total bilateral deafness. Two patients who are unilaterally deaf have good residual hearing. Two other patients regained hearing within normal limits after treatment with corticosteroids. No hearing symptoms were observed in one patient who had severe vertigo and whose condition is stable. Seventeen patients had vertigo: 11 have no labyrinthine function, 1 had absent responses on vestibular testing initially but currently demonstrates good responses, and the 5 others have remained stable with diminished vestibular function. If Cogan's syndrome is diagnosed early and treatment with corticosteroids is initiated promptly, hearing can be stabilized; otherwise, the prognosis for auditory function is poor.
 ...
PMID:Cogan's syndrome: audiovestibular involvement and prognosis in 18 patients. 387 92