Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042571 (vertigo)
 7,148 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An equilibriometric study has been performed on 20 healthy young women before and after the intake of 7 times 100 mg minocycline during 3 days. A systematic neurootological equilibriometry was performed analyzing the vestibular ocular, the vestibular spinal, the retino-ocular and the spontaneous nystagmus pathways. The results demonstrate that the tetracycline minocycline provokes a ponto-medullary liberation of the central vestibular regulating mechanisms. The central vestibular disinhibition could be exhibited by the monaurally elicited vestibular ocular nystagmus as well as by the radar image like cranio-corpography recordings of the head and body movements during a vestibular spinal stepping test. In parallel with these findings the participants of the study increasingly complained about vertigo of the rocking type, instability, malaise and wretching. Thus, the untoward side effects of a tetracycline like minocycline which is a frequent complaint of the patients, appears to be due to a central disinhibition of the vestibular equilibrium regulating mechanisms.
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PMID:[Equilibriometric measurements of central vestibular dysregulation following administration of minocycline]. 349 10

Modern neurootology has proved that many vertigo patients suffer from central dysequilibrium states. As vertigo patients are very frequent amongst our patient population we have to increase our diagnostic as well as therapeutical efforts. Since 1965, eliciting vestibular evoked cortical potentials has been possible. A method of evoked responses based upon computation of several stimulus responses has been used since then. Besides we are also using the frequency analysis of representative epochs of ongoing vestibular-ocular or retino-ocular reactions has been used since then. For diagnostic purposes we are combining various techniques like systematic history taking, ENG, ECG, CCG and BEAM. Brain electrical activity mapping (BEAM) is a newly developed tool, which we can also use for differentiating central from peripheral vestibular diseases. We are applying this technique for topographic correlates of vertigo related functional changes as well as for spatiotemporal analysis of cerebral evoked potentials due to vestibular stimulation. By means of a specific vestibular evoked potential technique, 6 typical cortical wave patterns can be elicited, which are displayed in the EEG curves as well as in colour maps of the whole scalp. The interactions between the various cortical structures are turning into an image similar to a weather map. BEAM, the fourth plan for projecting vertigo disorders, is now also bound into our concept for planning and monitoring a drug based therapy.
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PMID:Vestibular evoked responses: a new frontier in equilibriometry. 874 95