Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042510 (ventricular fibrillation)
10,091 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Authors present a case of a female patient with abundant attacks of rapid ventricular tachycardia and ventricular fibrillation, frequently resuscitated, who received an automatic cardioverter--defibrillator (AICD)--Ventak 1520 (CPI). Sooner 5-month pharmacotherapy with attainable drugs was deceptive. Operative and postoperative period was uncomplicated. During late 24-month follow-up 27 times a shock was delivered by the implanted cardioverter. Full patient's recovery was observed.
...
PMID:[Implantation of an automatic cardioverter-defibrillator--case report]. 263 78

A prospective study of advanced cardiopulmonary resuscitation (CPR) was carried out on 226 patients in order to examine factors predicting successful resuscitation and 6 month survival. The mean age of all patients was 70 years and median age was 74. Cardiopulmonary resuscitation was successful in 40.5% (137) of all arrests and in 48.7% (110) of the first arrests. Thirty of 207 patients with one or more cardiac arrests were discharged alive (14%). Twenty-one of our patients were alive at 6 months (10.3%). Patients in ventricular fibrillation and/or ventricular tachycardia at the time of arrest were more likely to have successful outcomes. When the patient required Isuprel or bicarbonate, cardiopulmonary resuscitation was significantly less successful. We found no correlation of immediate outcome with the following variables: location of arrest; time of day; pre-existence of shock; coma; stroke; malignancy. Uremia and/or chronic obstructive pulmonary disease was not significantly associated with failed resuscitation. Most notable in our results of specific treatments was the evidence for the need to improve the initial pH, particularly when it was less than 7.2. Failure to do so by the time the second blood gas was drawn was associated with failure of cardiopulmonary resuscitation. Our results also suggest that the adequate treatment of metabolic acidosis, and improved ventilatory management with improved PO2 and optimization of PCO2, play a role in the better outcome of cardiopulmonary resuscitation.
...
PMID:Cardiopulmonary resuscitation in a hospitalized population: prospective study of factors associated with outcome. 609 Dec 4

The syncopal attacks of complete heart block may be due either to ventricular standstill or to ventricular acceleration including fibrillation. As treatment may be harmful unless the underlying mechanism in each case is determined, it is important to apply the available methods for differentiation. Epinephrine and certain related compounds (sympathomimetic amines) are the only effective substances in the therapy of ventricular arrest. Isopropyl nor-epinephrine is a most potent drug in the prevention and treatment of ventricular arrest and has the advantage that it does not dispose to fibrillation. Quinidine is unreliable and probably hazardous in the control of ventricular fibrillation in heart block as it appears to precipitate this arrhythmia.Preliminary observations indicate that ectopic ventricular rhythms are also induced by procaine amide in complete heart block.Isuprel(R) may be of value in the therapy of ventricular acceleration, by preventing the ventricular arrest which frequently follows the initial acceleration.
...
PMID:MECHANISM OF SYNCOPE AND ACTION OF DRUGS IN COMPLETE HEART BLOCK. 1873 18