Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To evaluate the validity of magnetic resonance imaging for the follow-up of percutaneous ethanol injection therapy, 14 patients with a single hepatocellular carcinoma lesion smaller than 2.5 cm in diameter underwent MR imaging at 0.5 Tesla before and after treatment. Posttreatment follow-up examination included ultrasonography, contrast-enhanced computed tomography, and fine-needle biopsy in all cases. Only one patient showed recurrence within the 12-month follow-up period. After treatment, HCC lesions showed hypointensity on T1-, and T2-weighted images that lasted 12 months after treatment. In three cases, wedge-shaped hyperintense regions peripheral to the HCC nodule were observed after treatment on T2-weighted images. Obstructive vasculitis of the portal vein was considered to occur as a result of the drainage of ethanol injected in the tumor. These MR imaging findings may be helpful in clinical practice.
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PMID:Percutaneous ethanol injection therapy for hepatocellular carcinoma: validity of MR imaging in the evaluation of treatment effect. 756

To examine mid-term benefits on hepatic complications, extrahepatic clinical syndromes and quality of life associated with HCV cure; to review the few safety issues linked to oral direct-acting antivirals (DAAs); and to discuss the potential population benefits of reducing the burden of HCV infection. DAAs cure HCV infection in more than 95% of patients. The halting of liver inflammation and fibrosis progression translates into both hepatic and extrahepatic benefits and reduces the need for liver transplantation. A reduction in the frequency of extrahepatic manifestations such as mixed cryoglobulinaemia and vasculitis and improvements in quality of life and fatigue have also been described. A few safety issues linked to DAAs such as the potential recurrence of aggressive HCC, the flares of hepatitis B virus in patients with overt or occult HBV infection are been discussed. Curing HCV infection also has a high potential to reduce the burden of HCV infection at the population level. With widespread scaling up of HCV treatment, several modeling studies suggest that major reductions in HCV prevalence and incidence are possible, and that elimination of viral hepatitis is an achievable target by 2030.
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PMID:The benefits of hepatitis C virus cure: Every rose has thorns. 2911 4