Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a randomized controlled trial, 102 cemented Stanmore 28-mm metal-on-metal total hip arthroplasties (THAs) were compared to 98 metal-on-polyethylene THAs in 195 patients. At a mean follow-up of 10 years, 11 patients (11 hips) were lost to follow-up, 53 patients (55 hips) died, and 6 patients (6 hips) underwent revision. Average age of the surviving patients was 79 years. Harris Hip Scores and Oxford Hip Scores had increased significantly in both groups (P=.000). Ten years postoperatively, mean Harris Hip Score was 86 in the metal-on-metal patients and 87 in the metal-on-polyethylene patients (P=.441); Oxford Hip Scores were 27 and 24, respectively (P=.494). Wear was present in 30 of 52 polyethylene cups. Periprosthetic radiolucencies were seen in 57% of the metal-on-metal patients and in 52% of the metal-on-polyethylene patients (P=.680); they were mainly seen in DeLee & Charnley's zones 1 and 2. Serum cobalt and chromium concentration were higher in the metal-on-metal group (cobalt 1.1, chromium 1.0 vs 0.5 and 0.5 mug/L, respectively; P<.001). Patients with high ion levels (maximum 9.5 and 11 mug/L, respectively) all showed high Harris Hip Scores and few or no periprosthetic radiolucencies, and none were revised. Ten-year survival was 95.5% in the metal-on-metal group (4 revisions) and 96.8% in the metal-on-polyethylene group (2 revisions; P=.402). All revisions were indicated for aseptic loosening. One case of aseptic lymphocytic vasculitis-associated lesions and no pseudotumors were observed. The absence of clinical superiority of the cemented metal-on-metal bearing and the concerns over their biological effects have led us to favor the cemented metal-on-polyethylene THA.
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PMID:No superiority of cemented metal-on-metal over metal-on-polyethylene THA in a randomized controlled trial at 10-year follow-up. 2034 63

With the increased use of metal-on-metal as a bearing surface, complications and side effects are being recognised more frequently. We present a small series of a previously unreported complication, which appears specific to metal-on-metal bearing surface arthroplasties: three cases of infection in the presence of local metal debris and histological features of aseptic lymphocytic vasculitis associated lesions (ALVAL). Each case is associated with significant soft tissue loss and bone destruction to such an extent that pelvic discontinuity has occurred. We postulate that the combination of metal debris, ALVAL and tissue necrosis provides a unique environment for peri-prosthetic bacterial growth and rapid spread of infection.
Hip Int
PMID:The relationship between the presence of metallosis and massive infection in metal-on-metal hip replacements. 2054 66

There has been growing concern regarding the systemic and local effects of metal ions released from metal-on-metal hip resurfacings and total hip replacements, including the development of aseptic lymphocyte dominated vasculitis associated lesions (ALVAL). We describe our experience of treating 13 patients with failed metal on metal bearing hip prostheses secondary to this condition. Hip revision occurred at mean of 45 months following primary surgery. Groin pain was present in all patients. Other common features included large bursal swelling and mechanical symptoms. 3 patients developed their symptoms immediately postoperatively. The mean time to presentation was 21 months. Radiographic abnormalities noted included 3 patients with cup loosening and 2 patients with neck thinning. The mean cup inclination was 52 degrees. Surgical findings included bursal swellings and creamy brown fluid. Osteolysis was rarely seen. 12 revisions were achieved with primary implants and all patients had immediate symptomatic improvement. One patient was left with a pseudoarthrosis due to extensive soft tissue destruction. Diagnosis of ALVAL was confirmed histologically. The diagnosis of ALVAL should be considered in patients with unexplained pain from a metal on metal bearing hip arthroplasty. Surgical findings are typical and symptoms tend to resolve reliably following conversion to an alternative bearing surface.
Hip Int
PMID:Clinical experience of revision of metal on metal hip arthroplasty for aseptic lymphocyte dominated vasculitis associated lesions (ALVAL). 2127 62

Hip resurfacing in young patients has been increasingly performed within the last decade. In comparison to standard total hip arthroplasty the failure rate remains high. Age and implant size have a significant effect on the risk of revision for primary total resurfacing and the risk of revision increases with increasing age. At 7 years the cumulative revision rate for patients is 5% and females have more than twice the cumulative revision rate as males. Even in hip resurfacing arthroplasty which has been performed in a perfect manner, a certain percentage of patients suffer from persistent pain for various reasons, such as neck fracture, iliopsoas tendinopathy, metal hypersensitivity, such as aseptic lymphocytic vasculitis associated lesions (ALVAL) and aseptic loosening. Diagnostic work-up of the painful hip resurfacing is challenging even for experienced surgeons. Recommendations for the diagnostic procedure are described.
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PMID:[Approach to painful hip resurfacing]. 2161

Hip resurfacing arthroplasty was introduced as an alternative to the conventional total hip arthroplasty which had shown suboptimal results in younger patients. Application of the resurfacing technique in younger patients has increased over the last few years. To date, no randomized controlled trials with a minimum follow-up span of 10 years comparing hip resurfacing to conventional hip replacement have been conducted in patients under 55 years of age. Australian and English hip registries demonstrate high revision rates after 5 years for some brands of resurfacing implants. In addition to these disappointing revision rates, the complication of aseptic lymphocytic vasculitis caused by metal particles evoking a local tissue reaction has been increasingly reported. The resurfacing procedure recently received some negative media attention in the Netherlands, leading to confusion among patients. In order to ease patient doubts, it is important to correctly inform them as to the type of implant used, for example, by means of the website or an information card.
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PMID:[Hip resurfacing in patients under 55 years of age]. 2193 67

Concerns have recently been raised about large head metal-on-metal total hip arthroplasties (LDH THA). Metal ion release due to wear may cause osteolysis, pseudotumours and necrosis. In addition, fixation of certain acetabular components is thought to be suboptimal. We present the short term outcome of the Durom LDH THA. Retrospectively, a consecutive series of 64 implants in 60 patients was analysed with a mean follow-up of 37 months. Clinical and radiological evaluation was performed on a regular basis, followed by additional evaluations when indicated. The 10-year revision percentage was calculated and compared with National Institute for Health and Clinical Excellence (NICE) standards. Six patients (six hips) underwent cup revision (9%). Four of these cups showed no or minimal bone fixation. Three patients had a pseudotumour. In two revision cases, ALVAL (aseptic lymphocyte-dominated vasculitis-associated lesion) was present. Lack of bone ingrowth and the presence of ARMD (adverse reaction to metal debris) seem to contribute to a high failure rate of the Durom LDH THA. The predicted ten-year revision rate of 14.2% (95% CI 5.6-22.8) is, given the broad confidence interval, not significantly outside NICE recommended standards. However, it is not clear which factors, if any, predict implant failure. Therefore, we do not advocate the use of this implant.
Hip Int
PMID:Early failures in large head metal-on-metal total hip arthroplasty. 2323 78

Hip arthroplasty is commonly performed on patients with debilitating hip disease to relieve symptoms and improve quality of life. Generally, long-term success rates are excellent. However, a subset of patients requires revision due to prosthesis failure. A wide array of microscopic findings can be seen in surrounding tissues and many of the findings are etiologically nonspecific. The aim of this review is to discuss the etiologies and accompanying adverse tissue reactions seen with prosthesis failure, including the findings seen in aseptic lymphocyte-dominated vasculitis-associated lesion. Aseptic lymphocyte-dominated vasculitis-associated lesion is an important diagnostic consideration as its proposed pathogenesis is a type VI hypersensitivity response to metal ions. In addition, we also propose a diagnostic algorithm that incorporates clinical and histopathologic findings to suggest an etiologic cause. This proposed algorithm may be clinically useful as, to date, there is no consensus on nomenclature.
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PMID:Adverse tissue reactions after total hip arthroplasty. 2769 25