Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

16 patients of Wegener's granulomatosis, 4 of allergic angiitis and granulomatosis, 3 of lymphomatoid granulomatosis and 1 of necrotizing sarcoid granulomatosis were reported. In this group of different diseases, characteristic pathological manifestations are inflammatory cellular infiltration of vessel wall combined with destruction and necrosis of pulmonary parenchyma. There was little difference in their clinical features. In most of the cases, fever and systemic symptoms related to lung and extrapulmonary organs were present. Correct diagnosis of these diseases is very important, because both the prognosis and therapy are different. As for the prognosis, it ranges from benign (necrotizing sarcoidal granulomatosis) to very malignant (lymphomatoid granulomatosis). The clinical features of each illness were reviewed with emphasis on their histopathologic findings. The therapeutic effect and final outcome were followed.
Zhonghua Nei Ke Za Zhi 1992 Jul
PMID:[Pulmonary angitis and granulomatosis]. 129 98

115 cases of immunocompromised patients complicated with fungal pneumonia treated during the period from April 1968 to December 1986 were retrospectively studied. 96 were male and 19 female. Their age ranged from 6 to 84. The incidence increased significantly in recent years especially after 1983. Severe liver disease was the underlying disease in 102 (88.7%) patients. 108 (93.9%) had received antibiotics and 55 (47.9%) corticosteroids. Fungi species isolated were candida in 107 (54.9%), aspergillus in 82 (36.9%), penicillium in 7 (3.6%), mucormycetes in 6 (3%) and reotrichum in 3 (1.5%). Fever, cough, expectoration, moist rales diminished breath sounds and increase of W. B. C. and neutrophils were the important clinical features. The roentgenologic findings vary with the nature and extent of the pathologic process. Disseminated mycoses were found in 9 of the 18 autopsied cases. The characteristic pathologic findings were inflammation, abscess formation, vasculitis, infarction and hemorrhage. Extrapulmonary features such as enteritis, purulent nephritis, abnormal EKG, encephalopathy and rash were present. 93 cases received antifungal therapy including garlicin, clotrimazole, amphotericin B, nystatine, miconazole, 5-fluctosine and ketoconazole. Because these drug combinations were so complex, it is difficult to evaluate their efficiency. However the survival rate was somewhat elevated in recent years. The mortality rate of this series was 80.9%.
Zhonghua Nei Ke Za Zhi 1989 Jan
PMID:[A retrospective study of 115 cases of fungal pneumonia]. 273 37

The author reported a clinical study of 8 cases of Churg-Strauss vasculitis which is a rare disease of unknown cause. The clinical features include allergic rhinitis (69%), sinusitis (88%), asthma (98%-100%), mononeuropathy (66%-98%), pulmonary infiltration and peripheral blood eosinophilia. The histopathologic manifestations are characterized by eosinophilic infiltration, granulomatous lesion and necrotising vasculitis. The lesions mentioned above may not appear simultaneously, but they may exist in different combinations. Therefore, not all the manifestations may be seen in a single biopsy specimen. According to the diagnostic criteria recommended by American College of Rheumatology Subcommittee on Classification of Vasculitis in 1990, 6 cases of this series can be diagnosed. The remaining 2 cases were confirmed by pathologic examination. This kind of vasculitis responds to steroid treatment with satisfactory results.
Zhonghua Nei Ke Za Zhi 1994 Aug
PMID:[Churg-Strauss vasculitis]. 788 43

Primary vasculitis, include microscopic polyarteritis (MPA) and Wegener's granulomatosis (WG), is one of the causes of Glomerulonephritis and renal failure. Recently antineutrophil cytoplasmic autoantibodies (ANCA) is considered to be a very important tool for the diagnosis of MPA and WG. The management of ANCA was performed in 42 patients with variant primary glomerulonephritis with crescents formation or sclerotic glomerulonephritis, 5 of them show positive, appeared as a pattern of P-ANCA. Most of the patients were old male, with fever, malaise, weight loss, anemia, muscle and joint pain, some of them have chronic cough, even hemoptysis, opacities in middle-lower fields of both lungs, which didn't response to antibiotics therapy. This is the first report about renal involvement of primary vasculitis from China. Our result suggest that primary vasculitis is not a rare course of renal failure in China.
Zhonghua Nei Ke Za Zhi 1993 Jan
PMID:[The renal involvement of primary vasculitis: clinical and pathological analysis of 5 cases]. 840 17

We analyzed the clinical and pathological characteristics of patients with idiopathic rapidly progressive glomerulonephritis (idiopathic RPGN), who had been hospitalized in recent three years. Five out of 8 patients with idiopathic RPGN were positive for anti-neutrophil cytoplasmic autoantibodies (ANCA), most of them showed pANCA by indirect immunofluorescence technique. Compared with those who were ANCA negative, ANCA positive patients had an elder onset age; most of them had fever, arthragia, myalgia, skin rash, and some patients also had deafness, eye and nasal disorders. ANCA positive patients had a positive CRP, elevated gammaglobulins and accelerated ESR (> 100 mm/1 h). Typical pathological findings for ANCA positive patients were focal segmental fibroid necrosis of the glomerular capillary tufts and diffuse crescents formation. After an intensive therapy, the renal functions of most ANCA positive patients were obviously improved and most of them became hemodialysis independent. The results suggested that idiopathic RPGN might be a renal limited form of small vessel vasculitis and the patients with idiopathic RPGN had a better prognosis. Early diagnosis and appropriate intensive therapy are critical for patients with idiopathic RPGN.
Zhonghua Nei Ke Za Zhi 1997 Sep
PMID:[Idiopathic rapidly progressive glomerulonephritis and small vessel vasculitis]. 1043 70

We investigated pauci-immune crescentic glomerulonephritis (PICGN) in Chinese patients, During 11 years (1985-1996), 5,800 patients underwent renal biopsy in Nanjing Jinling Hospital. Eighteen patients were diagnosed as having PICGN. They were 11 women and 7 men with median age of 29 (range 10-71 years). Polyarteritis (33.3%) and polyarteritis nodosa (11.1%) were the secondary diseases. The incidence of PICGN was 0.31% in renal biopsies and 23.10% in crescentic glomerulonephritis. Clinically, most patients (83.3%) showed rapidly progressive nephritis with enlarged kidneys. Gross hemoturia was noted in 61.1% patients, hypertension 44.4%, nephrotic syndrome 44.4%, and oligria 33.3%. However, systemic symptoms were rare except anemia. Pathologically, we observed necrosis of glomerular capillaries (61.1%), infiltration of monocytes and neutrophil cells in glomeruli (44.4%), and vasculitis in interstitium (55.5%), in addition to glomerulosclerosis (44.4%), severe tubular atrophy (83.3%) and interstitial fibrosis (72.2%). Antineutrophil cytoplasmic antibodies (ANCA) was positive in 41.7%. All patients except one received intensively immunosuppressive therapy. 12 patients were subjected to long-term follow up (median 25.9, range 8-72 months). Only three patients were dialysis-dependent, while none died.
Zhonghua Nei Ke Za Zhi 1997 Nov
PMID:[Clinical and pathological characteristics in Chinese patients with pauci-immune crescentic glomerulonephritis]. 1045 45

A 29-year-old woman was admitted to the Department of Rheumatology, Peking Union Medical College Hospital due to intermittent rashes, fever and headache. Palpable purpura were symmetrically distributed on the extremities and trunk. Other manifestations included headache with nausea and vomiting. Elevated white blood cell (WBC) count, platelet (PLT) count, erythrocyte sedimentation rate (ESR) and C-reactive protein were the main laboratory findings. Antinuclear antibodies and antineutrophil cytoplasmic antibodies were negative. Examination of the cerebrospinal fluid (CSF) revealed high intracranial pressure, while routine cytology and biochemical tests of CSF were normal. Head MRI scan and PET-CT did not detect remarkable findings. A diagnosis of systemic vasculitis was confirmed by the biopsy of skin lesion which showed inflammatory infiltration of the muscular vessel wall. Combination therapy of corticosteroids and cyclophosphamide lead to a rapid improvement in clinical symptoms and laboratory parameters. The patient was in stable remission till 6 month follow-up.
Zhonghua Nei Ke Za Zhi 2016 Jul 01
PMID:[The 451(th) case: intermittent rash, fever and headache]. 2737 2