Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The case is reported of a 50 year old man with longstanding seronegative rheumatoid arthritis who developed ulcerative colitis. The patient also had sacroiliitis and his tissue was typed as HLA-A2-B27 several years before the bowel disease began. A possible overlap between primary inflammatory bowel disease, complications to the treatment of rheumatoid arthritis with drugs, and gastrointestinal rheumatoid vasculitis is discussed.
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PMID:Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroiliitis. 141 8

Fifteen patients suffering from serpiginous choroiditis were followed up for 1 to 10 years (mean 4.9 years). There were 7 women and 8 men with ages ranging from 20 to 65 years (mean 35 years). In 13 patients both eyes were involved. Ten of the 15 patients had both inactive scars and fresh lesions when first seen. The individual lesions resolved in a few weeks but, due to the gradual extension of the primary lesions centripetally in the shape of halos or pseudopods, signs of activity were observed for 1 to 9 months after the initial examination. After an interval of 3 months to 4 years, new recurrences were found in 8 patients; in some of them progression was noticed on serial fundus photographs only. Central vision was lost in 6 eyes, in 2 of them due to a subretinal neovascular membrane. Progression and recurrences could not be prevented by antituberculous medication or systemic corticosteroids. The cause of serpiginous choroiditis remains unknown but, on the basis of the fluorescein angiography, occlusion of the uveal vessels, possibly due to an immune vasculitis, is suggested. Immunological studies revealed no signs of diffuse vasculitis. Of the histocompatibility antigens, HLA-A2 was found in five and HLA-B7 in 4 of the 6 patients studied.
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PMID:A follow-up study on serpiginous choroiditis. 617 87