Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective study, sera from over 700 patients with suspected vasculitis, including over 200 patients undergoing renal biopsy, were examined for antibodies to neutrophil cytoplasmic antigen (ANCA). An indirect immunofluorescence assay on ethanol fixed human neutrophils identified two types of autoantibody: C-ANCA, which produces diffuse cytoplasmic staining and P-ANCA, which produces an artefactual nuclear/perinuclear staining pattern. The diagnosis of patients in whom ANCA of either form was found was established following case note review according to defined diagnostic criteria. Forty of 45 patients whose sera contained C-ANCA at a titre of greater than or equal to 1/40 satisfied the diagnostic criteria for Wegener's granulomatosis or microscopic polyarteritis. Twelve of 30 patients with P-ANCA at a titre of greater than or equal to 1/40 were also classified as having one of these disorders. Seventeen of the remaining 18 patients had immune-mediated disorders with deep organ damage. Of 47 ANCA-positive patients who underwent renal biopsy, 21 had glomerulonephritis associated with Wegener's glomerulonephritis and a further 22 had a necrotizing or crescentic glomerulonephritis. Ethanol fixation is important for discrimination of C-ANCA and P-ANCA. C-ANCA are highly specific for Wegener's granulomatosis and microscopic polyarteritis. In patients undergoing renal biopsy, the presence of these antibodies is highly specific for a necrotizing or crescentic glomerulonephritis.
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PMID:Antibodies directed against neutrophils (C-ANCA and P-ANCA) are of distinct diagnostic value in systemic vasculitis. 229 Sep 22

An unusual case of traumatic basal subarachnoid hemorrhage (SAH) due to a mechanical tear of the basilar artery is reported. A 70-year-old man who had been suffering from cerebrovascular dementia was found dead in a ditch. Externally, subcutaneous hemorrhage with abrasions was observed on the left side of the forehead, face, and lower jaw, together with small contusions in the left superciliary arch. Internally, a 3-mm-long transversal tear of the basilar artery was observed, and dislocations of both C6-C7 and T1-T2 as well as a small fracture of the processus spinosus of C5 were found. No pathological vascular lesions such as aneurysms and vasculitis, other than arteriosclerosis, were observed in the vertebral-basilar system. Ethanol was not detected in the intracardiac blood or in the urine. These findings indicate that when the man fell into the ditch, severe hyperextension occurred as a result of minor blunt forces to the face, and that the traumatic tear of the basilar artery was mechanically caused by overstretching due to hyperextension of the head. It is also suggested that due to his advanced age the muscle tone of the neck might have declined, impairing its defense action, and that head hyperextension might, therefore, occur rather more readily under such conditions.
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PMID:Traumatic tear of the basilar artery associated with vertebral column injuries. 918 27