Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical sarcocystosis was studied in 37 goats after inoculation with graded doses of sporocysts of Sarcocystis capracanis. Eight uninoculated goats served as controls. Clinical response varied with the dose. Goats inoculated with 10-40 million sporocysts died between 11 and 13 days after inoculation (DAI), from interstitial pneumonia, vasculitis, and necrosis of mesenteric lymph nodes. All goats inoculated with 100,000 or 1 million sporocysts died between 19 and 23 DAI; clinical signs were anorexia, fever (40-41 C), anemia, and weight loss. Four of 4 goats inoculated with 50,000 sporocysts and 1 of 4 inoculated with 10,000 sporocysts died 24, 28, 39, 68, and 61 DAI, respectively. Goats inoculated with 1,000 sporocysts and uninoculated goats remained clinically normal. After day 18 and before day 68, packed cell volume and hemoglobin content decreased to as low as 11% and 3.6 g/dl, respectively. Alanine aminotransferase and lactic dehydrogenase activities were inconsistently increased. Blood urea nitrogen and bilirubin values were increased, reaching as high as 63 mg/dl and 10 mg/dl, respectively. Histologically, thymic atrophy, vasculitis, hepatitis, cholangitis, myocarditis, generalized myositis, and encephalomyelitis were the main microscopic findings. The cause of the anemia in goats that died after day 19 was not determined.
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PMID:Sarcocystosis in goats: clinical signs and pathologic and hematologic findings. 678 65

The course of chronic viral hepatitis C (CVH C) depends in large degree from on non-specific immunological response. Interferon-alpha 2a (IFN-alpha 2a) affects immunological responses including acute phase proteins. The aim of the study was to determine whether chronic hepatitis C affects acute phase proteins and whether treatment with interferon-alpha restores disturbed acute phase proteins concentrations. Concentrations of acute phase proteins were compared with aminotransferases activity, a standard indicator of hepatocyte damage. We studied twenty patients (from 21 to 53 years old) with CHV C treated with interferon-alpha 2a (6 million units, three subcutaneous injections a week). CRP, fibrinogen, C3 and C4 components of complement and albumin serum concentrations were determined before treatment, after 6 and 36 doses of interferon (after 2 and 12 weeks of therapy). Alanine aminotransferase activity was checked at the same time. No abnormalities in CRP, fibrinogen and albumin levels were observed before and during the treatment. It is regarded that low concentrations of C3 and C4 can lead to cryoglobulinemia, vasculitis, and polineuropathy. Both C3 and C4 were decreased among patients with CVH C. During therapy with interferon; levels of both proteins increased and achieved normal levels, especially among patients with effectiveness therapy of IFN-alpha.
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PMID:[Activation of acute phase proteins in patients with chronic hepatitis C treated with interferon-alpha 2a]. 1139 10