Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Takayasu's arteritis is a primary vasculitis that affects large vessels and is characterized by chronic granulomatous inflammation. Diagnosis has been primarily clinical, with verification by angiography as the gold standard. More recently, however, it has become apparent that positron emission tomography enables better evaluation of vascular inflammation. This study presents 2 cases of Takayasu's arteritis. Magnetic resonance angiography was used to evaluate aortic anatomy by analyzing vascular wall thickness and also to quantify disease activity by measuring gadolinium enhancement. Positron emission tomography was used to evaluate active vascular inflammation by quantifying fluorodeoxyglucose F18 uptake. We conclude that both techniques support clinical diagnosis and aid in the evaluation of disease activity during and after treatment.
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PMID:Pre-pulseless Takayasu's arteritis evaluated with 18F-FDG positron emission tomography and gadolinium-enhanced magnetic resonance angiography. 1817 33

We present a case of a 38-year-old man with a prior episode of fever of unknown origin (FUO) four years ago who presented with acute severe dull nonradiating abdominal pain centered in the epigastric region associated with nausea and vomiting. Bloodwork showed a normal leukocyte count but elevated erythrocyte sedimentation rate of 26 and elevated C-reactive protein of 40; syphilis titers and anti-neutrophil cytoplasmic antibodies (pANCA and cANCA) were negative. CT angiogram (CTA) of the abdomen and pelvis showed diffuse medium vessel vascular inflammation. Indium-111 labeled leukocyte scan did not show evidence of infection and, specifically, no evidence of infectious vasculitis. Subsequent F18-FDG PET/CT scan showed diffuse uptake in the mesenteric vasculature in the area of abnormality seen on prior contrast-enhanced CT and confirmed the diagnosis of vasculitis, subsequently deemed by rheumatology to be most consistent with segmental arterial mediolysis.
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PMID:F18-FDG PET/CT Diagnoses Vasculitis after a Negative Indium-111 Leukocyte Scan. 3248 80