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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ocular manifestations of Wegener's granulomatosis may occur secondary to contiguous granulomatous sinusitis or as a result of focal vasculitis. Contiguous granulomatous sinus disease causes nasolacrimal duct obstruction, proptosis and ocular muscle or optic nerve involvement. Focal vasculitis unrelated to contiguous upper respiratory tract disease is manifested by conjunctivitis, episcleritis, scleritis, corneoscleral ulceration, uveitis, and granulomatous vasculitis of the retina and optic nerve. A review of 29 cases of Wegener's granulomatosis and three cases of lymphomatoid granulomatosis studied over the past 15 years at the National Institute of Allergy and Infectious Diseases (NIAID) disclosed single or multiple ocular manifestations of disease in 15 patients (47 per cent). The pattern of ocular disease, its relationship to systemic involvement, diagnostic methods and the response to therapy are discussed.
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PMID:The ocular manifestations of Wegener's granulomatosis. Fifteen years experience and review of the literature. 32 2

Vasculitis is a heterogeneous group of diseases which is characteristic by inflammatory cellular infiltration of the vascular wall often being concomitted by fibrinoid necrosis. The pre-condition for stating the diagnosis is the primary localization of inflammation in the vascular wall. Affliction of vessels can be focal or segmental. Focal vasculitis afflicts merely a part of the vessel's wall perimeter, and aneurysms may develop. Segmental vasculitis refers to a lesion of the entire perimeter of the vascular wall which often leads to stenosis or occlusion of the vessel. Non-specific histologic findings of perivascular infiltrates cannot be considered as evidence of vasculitis. The authors present the classification of vasculitis, its development and relation to etiopathogenesis of the disease, including histopathology and clinical symptoms. (Fig. 1, Tab. 9, Ref. 43.).
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PMID:[Classification and pathogenesis of vasculitides]. 862 Mar 24

Involvement of the central nervous system is uncommon in progressive systemic sclerosis, with only 2 reported cases associated with intracerebral hemorrhage detected by neuroimaging. A 55-year-old woman with a 10-year history of scleroderma presented with left occipital lobe hemorrhage manifesting as headache and vomiting. She had no signs of hypertension, diabetes mellitus and hyperlipidemia. CT and MRI, on admission, showed left occipital lobe hemorrhage with ventricular rupture and acute left subdural hematoma. Serial cerebral angiography was performed on day 0, day 7 and day 14, and found no evidence of aneurysm, arteriovenous multiformation or tumor stain in the left occipital lobe. However, the bilateral anterior cerebral arteries showed increasing segmental narrowing suggestive of vasculitis. Histological examination of a section from the brain cortex adjacent to the hemorrhage revealed no evidence of vasculitis, fibrinoid degeneration or amyloid deposition. Focal vasculitis may have occurred secondary to the homorrhagic lesion.
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PMID:[A case of left occipital lobe hemorrhage in a patient with progressive systemic sclerosis: evaluation of cerebral angiography and histology]. 1112 85