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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary eosinophilia is an anatomo-clinical entity in which pulmonary parenchymatous infiltrates are associated with tissue hypereosinophilia. Blood eosinophilia which is very frequent but not absolutely constant makes the diagnosis likely. Four case reports illustrating pathophysiological mechanisms show its reality in pediatrics as well as its etiological diversity: parasitosis (filariasis), allergic bronchopulmonary aspergillosis complicating cystic fibrosis, vasculitis (Churg-Strauss syndrome) and chronic pulmonary eosinophilia, the last diagnosis being a diagnosis of exclusion. Pulmonary eosinophilia is rare in children and might not be recognized by pediatricians. Diagnosis might be urgent, in the case of dyspnea, hypoxia and/or threatening respiratory signs. The severity of some pulmonary eosinophilias emphasizes the toxicity of the eosinophil granulocyte content. Especially, the major basic protein is capable of destroying the pulmonary epithelium and of facilitating human basophil degranulation. The effect of corticosteroid therapy, spectacular in chronic pulmonary eosinophilia, may be related to their inhibitory effect on eosinophils and by stabilizing cellular membranes.
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PMID:[Eosinophilic lung in children]. 376 84

Pulmonary eosinophilia is a parenchymatous disorder with tissue eosinophilia (with or without blood eosinophilia). It remains ill understood whether from the pathophysiological, diagnostic, aetiologic or therapeutic standpoint. This paper takes stock of the principal classifications used and the necessary stages in the diagnostic approach. First, current understanding of the function of the eosinophil is discussed. The method of searching for a precise aetiological diagnosis is reviewed under the general headings of "parasitic", "fungal" and "drug induced". Pulmonary eosinophilia wih vasculitis and idiopathic eosinophilia have then considered. The authors stress the importance of establishing a eosinophilia have then considered. The authors stress the importance of establishing a precise aetiology and searching for extra pulmonary lesions or evidence of vasculitis in the management of pulmonary lesions or evidence of vasculitis in the management of pulmonary eosinophilia. As regards treatment, particularly of prolonged pulmonary eosinophilia, corticosteroids are relied upon. For some this may be after a test trial of anti-parasitic therapy.
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PMID:[Pulmonary eosinophilia: current concepts, diagnostic and therapeutic advances]. 703 66

We encountered a 23-year-old woman with allergic granulomatous angiitis (AGA) associated with cerebral infarction, myo-pericarditis, and acute respiratory failure due to extended eosinophilic pneumonia. She underwent emergency treatment at our hospital because of right hemiparesis and impaired consciousness. AGA was suspected because the patient had a history of bronchial asthma accompanied by pulmonary infiltrations with eosinophilia, and presented with diffuse pulmonary infiltrates, pericardial effusion, diffuse hypokinesis of myocardium, cerebral infarction and marked peripheral eosinophlia. Pulmonary eosinophilia was confirmed by examination of broncho-alveolar lavage fluid. Myocardial tissue biopsy specimens revealed fibrous granulation indicative of myocarditis. The patient responded well to corticosteroid therapy.
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PMID:[Allergic granulomatous angiitis associated with cerebral infarction, myo-pericarditis and acute respiratory failure due to eosinophilic pneumonia]. 991 84