Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a case of Wegener's granulomatosis, complicated by the development of pyopneumothorax due to the rupture of a cavity. This complication occurred despite treatment with corticosteroids and cyclophosphamide. Active vasculitis and impaired tissue repair are possible explanations for the occurrence of this complication and the fatal outcome in our patient.
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PMID:Pyopneumothorax: a rare complication of Wegener's granulomatosis. 407 61

Spontaneous pneumothorax in Wegener granulomatosis (WG) is uncommon. Three cases of pneumothorax that occurred early in the course of this vasculitis are reported. In the first patient, the disorder was disclosed by a pyopneumothorax. In the second patient, a rupture of the subpleural cavitary nodule into the pleural space was observed. In the third patient, the pneumothorax was discovered at the same time as a pulmonary hemorrhage. The three patients improved with immunosuppressive therapy. In WG, the pulmonary nodules are predominantly in the subpleural location, which entails the risk of pneumothorax and therefore require particular attention.
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PMID:Spontaneous pneumothorax in Wegener granulomatosis. 1623 88