Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 2-month-old female infant with pancarditis was reported. The patient died after a 26-day clinical course. The autopsy showed pancarditis, including inflammation in all 4 valves and chordae, fibrinoid vasculitis, pharyngolaryngitis and atrophy of the lymph nodes. Microscopic examination revealed proliferative inflammation in the endocardium, valve, myocardium, epicardium and coronary vessels. The histological findings suggested the etiology to be a rheumatic-type reaction at an extremely young age.
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PMID:An autopsied case of a two-month-old infant with granulomatous pancarditis having severe vasculitis and valvulitis. 664 38

A 16-year-old boy had toxic shock syndrome (TSS); Staphylococcus aureus bacteremia developed 11 hours prior to his death, which was three days after onset of the illness. The isoelectric focusing pattern of the staphylococcal isolate differed from both non-TSS and classic TSS S aureus isolates. Anatomic findings suggest three pathogenetic mechanisms: (1) immune complex-associated pulmonary microangiitis and vasculitis in the skin and skeletal muscle; (2) parenchymal cell "microvesicular" fatty metamorphosis in the liver, myocardium, renal tubules, and pancreas, and (3) pancarditis.
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PMID:A variant of toxic shock syndrome. Clinical, microbiologic, and autopsy findings in a fatal case. 668 93

The article is based on the results of studies of protocols of 65 autopsies, 42 medical histories and morphological studies of contemporary records of 47 hearts of the deceased servicemen from the Soviet troops in Afghanistan who died of typhoid. It was found out that myocarditis was developed in 61.9 7.3% of cases regardless of the existence and character of complications. The inalienable features of myocarditis were inflammatory changes (vasculitis, basically mononuclear infiltration of stroma, granulomas), vascular malfunctions (microcirculatory disorders, enhanced permeability of vessels, edema of stroma), dystrophic and necrotic changes in cardiomyocytes. Vasculitis had predominant significance in cardiac morphogenesis. Besides myocardium the inflammatory process had proliferated also on epicardium and mural endocardium, i.e. pancarditis.
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PMID:[The clinical morphology of cardiac involvement in typhoid in servicemen in Afghanistan]. 782 84

A 13-year-old girl presented to our emergency with a one week history of fever and skin rash and new onset of chorea for the last three days. There was a long standing history of right predominant headache; followed by personality change, fatigue, arthralgia and weight loss over the last few months. Previous investigations by head CT and ophthalmological examination did not explain the symptoms. Further investigations revealed peri- and pancarditis with aortic insufficiency, a renal involvement with elevated creatinin, protein- and hematuria and a hemolytic anemia. Diagnosis of lupus eythematodes was confirmed by high ANA, anti-dsDNS and Anticardiolipin antibodies. Within the first 48 hours after admission there was significant deterioration with reduced vigilance and dysarthria. MRI of the brain and dopplersonography of cerebral vessels showed a complete thrombosis of the right medial cerebral artery with a small net of collaterals, irregularities of the left cerebral artery due to vasculitis and several subacute leftsided ischemias. Immunosuppressive therapy with high-dose corticosteroids and cyclophosphamid together with antithrombotic therapy induced an improvement of neurologic, renal and cardiac function.
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PMID:[Vasculitis as a reason of chronic headache]. 1854 40