Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042384 (vasculitis)
 20,525 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With advancing age and in the absence of any disease, there is a significant alteration in kidney structure and a gradual decline in renal function. While RPF, GFR, and tubular reabsorptive capacity decrease with age, abnormal signs or symptoms cannot be detected under ordinary circumstances. The aging kidneys, however, have limited capacity to cope with rapid hemodynamic changes or disturbances in fluid and water balance, and this results in signs and symptoms of renal dysfunction. In the elderly, the incidence of primary renal diseases declines while the incidence of renal diseases secondary to systemic disease increases. AGN, while essentially a disease of the young, does occur in the older age group. RPGN, however, is the most common form of acute primary glomerulonephropathy, followed by membranous glomerulonephritis and glomerulosclerosis. Glomerulonephritis secondary to vasculitis and Wegener's granulomatosis and amyloidosis constitutes the most common secondary glomerulonephropathy. Drug-induced acute or chronic tubulointerstitial nephropathy is seen more frequently in the geriatric age group because of the high incidence of multiple-drug treatment. There is a high incidence of ARF in the elderly which is frequently precipitated by hypovolemia, hypotension, nephrotoxic drugs, surgery, and anesthesia. Clinical manifestations of renal disease in the elderly are often atypical and nonspecific. Abnormal signs and symptoms are frequently attributed to extrarenal diseases or to previously existing disorders. For these reasons, renal disease in the elderly may go undetected. Serum creatinine level may remain within normal range despite a drop in GFR because of a reduction in muscle mass with aging. Therefore, creatinine clearance is a more accurate test for assessment of renal function. A decrease in creatinine clearance should not be ignored or attributed to aging; it is an indication for further renal evaluation.
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PMID:Renal disease in the elderly. 633 24

This study among elderly renal Egyptian patients (n=220) with only 20 of them were subjected to renal biopsy. Results showed: diabetic nephropathy in 28.2%, hypertensive nephrosclerosis 25.5%, UTI, cystitis and pyelonephritis in 6.8%, renal stones in 5.9%, obstructive uropathy in 7.6%, simple cysts in 4.5%, CRF of unknown origin in 13.1%, and others in 26.4%. DM and HTN were S related to kidney function tests and increase in elderly. Other cardiovascular risk factors and smoking are reported by previous workers to be HS related to renal diseases. Age was significantly related to GFR, BUN and Cr. but sex difference was not significantly related to renal diseases. Multiple myeloma, lupus nephritis, vasculitis and hepatitis B were all recorded in few numbers of elderly Egyptians. HCV was more common and more likely to cause renal diseases. Abdomino-pelvic ultrasound was confirmatory to clinical renal diseases diagnosis. Among patients (n=20) biopsies showed focal necrotizing GN in 20%, membranous nephropathy in 50% and renal amyloidosis in 30%. CTIN was associated in some cases due to NSAID intake. Analgesic nephropathy was a common problem that might lead to ARF in some cases especially in the elderly. Ultrasound results among the biopsy group were confirmatory to clinical diagnosis.
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PMID:Pattern of renal diseases among elderly Egyptians patients with acute or chronic renal diseases in Ain Shams University and Nasser Institute Hospitals, Cairo, Egypt. 1633 99