Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1089
insulin 870
collagen 825
Mol 441
MRI 327
amyloid precursor protein 324
HDL 250
fibrinogen 228
apolipoprotein E 196
cytokine 188
angiotensin II 188
renin 187
cystatin C 184
C-reactive protein 176
nitric oxide synthase 164
vascular endothelium 163
albumin 160
amyloid beta 160
thrombin 147
hemoglobin 145
She 144
vascular endothelial growth factor 138
B12 124
endothelin-1 98
Ang II 97
von Willebrand factor 97
elastin 92
apolipoprotein 90
endothelial nitric oxide synthase 88
methylenetetrahydrofolate reductase 85
chronic renal failure 82
tumor necrosis factor 82
APOE 80
plasminogen activator inhibitor-1 79
Lp(a) 75
APP 74
TNF 74
apoE 73
IL-6 71
ADP 71
superoxide dismutase 70
calcium channel 69
vascular cell adhesion molecule-1 66
phosphodiesterase 66
Mal 65
PLA 65
VEGF 64
endoglin 62
glycoprotein 61
adiponectin 61
fibronectin 60
ACE 60
ATP 59
plasminogen 59
p38 59
eNOS 59
tissue factor 56
reductase 55
endoplasmic reticulum 53
plasminogen activator inhibitor 52
interleukin-6 51
axonal 51
LDL receptor 50
matrix metalloproteinase 50
prothrombin 50
CSF 50
CADASIL 49
platelet-derived growth factor 49
bradykinin 49
CD105 48
apolipoprotein B 47
protein C 46
serum albumin 46
antithrombin III 45
MAPK 44
Pol 43
cystathionine beta-synthase 43
catalase 43
E-selectin 43
ERK1 42
cyclooxygenase 42
P-selectin 42
CRP 42
precursor protein 42
tissue plasminogen activator 41
prion 41
chemokine 39
tyrosine kinase 39
caspase-3 39
adhesion molecule 38
HMG-CoA reductase 38
PDGF 38
ICAM-1 37
prion protein 37
A-I 37
CHA 37
transforming growth factor-beta 37
growth hormone 37
myeloperoxidase 36
intercellular adhesion molecule-1 36
Men 35
angiotensin receptor 35
CD4 35
reserved 35
gut 35
endothelin receptor 35
leptin 35
lipopolysaccharide 35
amyloid protein 35
HHT 35
Notch3 34
HLA 34
bone morphogenetic protein 34
NADPH 34
ALK5 34
lipoprotein lipase 33
NIDDM 33
TGF-beta 33
tau protein 32
apolipoprotein A-I 32
PI3K 32
p53 32
factor VII 32
ROS 32
NMR 31
TNF-alpha 31
CD31 31
Apolipoprotein E 30
interferon 30
Rho 29
factor VIII 29
smooth muscle actin 29
ubiquitin 29
MMP-9 29
protein S 28
glial fibrillary acidic protein 28
JNK 28
glucagon 28
ACVRL1 28
heme oxygenase-1 27
MMP-2 27
histone 27
GSH 27
AMP 27
glutathione peroxidase 27
peroxisome proliferator-activated receptor 27
natriuretic peptide 26
Adiponectin 26
ALK1 26
lymphoid 26
IL-1 26
estrogen receptor 26
THP 25
SOD 25
beta-thromboglobulin 25
cholesteryl ester transfer protein 25
peroxisome proliferator-activated receptor gamma 25
ET-1 24
thrombomodulin 24
xanthine oxidase 24
more...
Disease
vascular disease 17070
diabetes 2541
hypertension 2421
atherosclerosis 2079
stroke 1666
Alzheimer's disease 1496
cardiovascular disease 1227
dementia 904
myocardial infarction 647
coronary artery disease 612
plaque 601
pulmonary hypertension 555
cancer 524
ischemia 523
obesity 518
renal disease 496
type 2 diabetes 459
cognitive impairment 395
heart failure 369
coronary heart disease 365
vasculitis 312
hyperglycemia 298
heart disease 297
hyperhomocysteinemia 292
hyperlipidemia 280
peripheral vascular disease 263
myocardial ischemia 258
tumor 248
renal failure 243
neuropathy 242
hypercholesterolemia 233
systemic lupus erythematosus 233
retinopathy 232
amyloidosis 218
dyslipidemia 210
metabolic syndrome 209
arteriosclerosis 182
congestive heart failure 180
depression 169
transient ischemic attack 163
erectile dysfunction 147
diabetic retinopathy 145
PSS 144
abdominal aortic aneurysm 141
arteriopathy 139
CAA 138
Endothelial dysfunction 136
lung disease 124
proteinuria 122
rheumatoid arthritis 122
encephalopathy 120
chronic renal failure 120
lupus 117
leukoencephalopathy 116
subarachnoid hemorrhage 115
migraine 115
type 1 diabetes 110
ventricular hypertrophy 108
claudication 105
sepsis 101
dysplasia 101
HIV 100
Down syndrome 99
preeclampsia 99
cerebral ischemia 98
Parkinson's disease 98
anemia 97
cerebral infarction 95
lupus 94
scleroderma 93
microalbuminuria 93
HHT 93
cardiomyopathy 93
sepsis 93
moyamoya 92
acute myocardial infarction 91
osteoporosis 89
interstitial pneumonia 89
blindness 89
telangiectasia 89
diabetic nephropathy 88
gangrene 87
arthritis 87
glucose intolerance 86
ventricular septal defect 86
interstitial lung disease 86
pneumonia 85
essential hypertension 85
chronic obstructive pulmonary disease 82
deep vein thrombosis 81
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy 81
epilepsy 80
hyperinsulinemia 80
infectious diseases 79
homocystinuria 78
cytomegalovirus 77
intermittent claudication 76
renal artery stenosis 75
idiopathic pulmonary fibrosis 74
pulmonary embolism 73
Raynaud's phenomenon 71
cirrhosis 70
glaucoma 69
right heart failure 68
chronic disease 67
primary pulmonary hypertension 66
sarcoidosis 65
autoimmune disease 65
renal insufficiency 65
Pulmonary arterial hypertension 64
liver disease 63
Fibromuscular dysplasia 62
multiple sclerosis 61
peripheral neuropathy 60
malnutrition 60
hemiparesis 59
systemic disease 59
immunodeficiency 58
portal hypertension 58
bronchiolitis 56
cold 56
impotence 56
Takayasu 56
hydrocephalus 55
CAA 55
aortic aneurysm 55
thrombocytopenia 55
Buerger's disease 54
connective tissue disease 52
AIDS 52
hypoglycemia 50
sickle cell disease 50
unstable angina 49
Binswanger 49
carcinoma 49
varices 48
brain atrophy 47
CADASIL 47
glomerulosclerosis 46
arteriovenous malformation 44
uremia 44
giant cell arteritis 44
senile dementia 42
neurological disease 42
asthma 42
antiphospholipid syndrome 42
lymphoma 42
SEM 42
breast cancer 41
aortic stenosis 41
West 41
polyneuropathy 41
rare disease 40
tuberculosis 40
diabetic angiopathy 40
emphysema 39
renal impairment 39
coma 39
lung cancer 39
glomerulonephritis 39
more...
Symptom
pain 268
headache 176
seizures 143
angina 121
dyspnea 82
anesthesia 79
weakness 63
overweight 57
abdominal pain 56
diarrhea 36
vertigo 33
vomiting 33
cough 32
chest pain 31
ataxia 31
dizziness 29
fatigue 29
paresthesia 27
syncope 27
cyanosis 24
spasm 23
paresis 22
discomfort 22
discomfort 22
hypothermia 22
tremor 21
hemiplegia 21
collapse 21
dysarthria 21
numbness 20
erythema 20
livedo 19
back pain 18
myoclonus 18
respiratory distress 18
thinning 18
pallor 16
myalgia 16
memory loss 16
nausea 16
tinnitus 15
exertional dyspnea 14
hypercapnia 14
sleepiness 14
hemoptysis 13
cerebellar ataxia 13
paraparesis 12
arthralgia 12
fever of unknown origin 12
functional recovery 11
muscle cramps 11
analgesia 11
ophthalmoplegia 11
flushing 11
snoring 11
hyperoxia 11
anorexia 9
regurgitation 9
splenomegaly 9
lethargy 9
agitation 9
leg pain 8
chorea 8
insomnia 7
starvation 7
cachexia 7
blurred vision 7
neck pain 6
tonic-clonic seizure 6
shortness of breath 6
dystonia 6
HSA 6
spasticity 6
oliguria 6
loin pain 6
bradykinesia 6
wheezing 5
chills 5
epigastric pain 5
low back pain 5
consciousness disturbance 5
stigma 5
flank pain 5
apathy 5
constipation 5
acute abdomen 5
clubbing 5
tachypnea 4
abnormal gait 4
exhaustion 4
personality change 4
Ill 4
nausea and vomiting 4
limb pain 4
polyuria 4
Stiffness 3
chronic cough 3
hoarseness 3
hot flashes 3
colic 3
dysesthesia 3
asthenia 3
hypotonia 3
prostration 3
facial pain 3
visual hallucination 3
acute abdominal pain 3
night sweats 3
forgetfulness 3
Depressive symptoms 3
photophobia 3
menopausal symptoms 3
intestinal bleeding 3
acute pain 3
shoulder pain 2
heartburn 2
cardiovascular disability 2
ENT 2
sneezing 2
cardiovascular impairment 2
groin pain 2
disturbed balance 2
hepatomegaly 2
anosmia 2
loss of taste 2
ketonuria 2
hepatosplenomegaly 2
hip pain 2
partial seizure 2
dry eye 2
acute stress 2
muscle stiffness 2
intestinal angina 2
DNA marker 2
productive cough 2
neck stiffness 2
meningism 2
tenesmus 2
abdominal discomfort 2
dysuria 2
intention tremor 2
skin damage 2
jaw pain 2
exertional chest pain 2
clumsiness 2
eds 2
neuralgia 2
right upper quadrant pain 2
tingling 2
ataxic gait 2
loss of balance 2
Sedation 2
polydipsia 2
sore throat 2
prostatism 2
sciatica 1
atypical chest pain 1
Respiratory symptoms 1
Air trapping 1
nerve root irritation 1
more...
Drug
Cardiovasc 562
Dermatol 91
vitamin E 57
CSF 52
Dial 51
lysine 40
Angiotensin II 38
Perindopril 36
Gliclazide 36
ROS 32
ascorbate 28
Nephron 25
Monit 24
Clopidogrel 24
pyridoxal phosphate 21
nitroglycerin 20
Nephron 20
Spectrum 18
THF 18
Pravastatin 17
BH4 16
niacin 14
NADH 13
Simvastatin 13
Fluorescein 12
Vitamin B12 12
Heme 11
Nitric Oxide 11
Fluorescein 11
CTA 11
MAP 10
caffeine 10
Albumin 10
Estrogens 10
Vitamin K 10
Ramipril 9
EE2 8
Captopril 8
ROC 8
Vitamin E 8
Vitamin B 8
ADM 8
IFN-gamma 8
ICI 7
Asn 7
Ezetimibe 6
Rosuvastatin 6
ENT 6
EPA 6
CTX 6
uPA 6
Histamine 6
Bevacizumab 6
Leaf 6
ABC 6
ETA 6
Norplant 6
Trental 5
Abciximab 5
FAD 5
Portal 5
Cilostazol 5
Xanthium 5
CVA 5
MRC 5
Arsenic trioxide 5
IL-2 5
Ranibizumab 5
TAT 4
Troglitazone 4
CaCl2 4
Iloprost 4
Paraffin 4
Lovastatin 4
Frontal 4
ampicillin 3
L-tyrosine 3
Alanine 3
citric acid 3
Azithromycin 3
Fraction 3
Norvasc 3
Clofibrate 3
Imatinib 3
ALA 3
Valsartan 3
Glucagon 3
Zmax 3
Bosentan 3
Levonorgestrel 3
Amlodipine besylate 3
Azelnidipine 3
CaCl2 3
CaCl2 3
EPI 3
Glutathione 3
Aliskiren 3
Bosentan 3
Rosiglitazone 3
Liraglutide 3
Viagra 3
Viagra 3
Gel 3
DHT 2
Ginseng 2
CAM 2
Alliance 2
ETS 2
DDAVP 2
CoCl2 2
Indapamide 2
CoCl2 2
Dexfenfluramine 2
Indomethacin 2
DDAVP 2
Sodium nitroprusside 2
Ethanol 2
G-CSF 2
CTX 2
Premarin 2
Coumadin 2
Isotretinoin 2
PTH 2
Indocyanine green 2
CTX 2
IL-1ra 2
HCH 2
Award 2
PDGF B-chain 2
ACT 2
EDR 2
CIA 2
Nebivolol 2
Exenatide 2
Raloxifene 2
Hypaque 2
Gelfoam 2
Activin 2
EHDP 2
Dakar 2
Aprotinin 2
DHT 2
Bayer 2
Cobalamin 2
Dasatinib 2
Mutagen 2
Levovist 2
Depo-Provera 2
Indapamide 2
Doxycycline 2
Antithrombin III 2
Treprostinil 2
Spectrum 2
Papaverine 2
Triad 2
Atenolol 2
PFA 2
Everolimus 2
Tao 1
Ulinastatin 1
more...
Enzyme
renin 187
mitogen-activated protein kinase 156
thrombin 144
ACE 109
NO synthase 103
NADPH oxidase 99
methylenetetrahydrofolate reductase 92
methylenetetrahydrofolate reductase 92
protein kinase C 85
superoxide dismutase 85
tissue plasminogen activator 76
ERK 71
NADPH oxidase 71
phosphodiesterase 66
protein kinase 64
APC 57
peroxidase 54
catalase 48
cystathionine beta-synthase 43
luciferase 38
NOS 37
focal adhesion kinase 36
elastase 34
plasmin 34
lipoprotein lipase 33
caspase-3 33
guanylate cyclase 29
glutathione peroxidase 27
thromboplastin 26
xanthine oxidase 26
paraoxonase 23
phospholipase A2 22
paraoxonase 22
CD10 21
acetylcholinesterase 21
alkaline phosphatase 21
ATPase 20
MEK 20
CAD 19
CAD 19
urokinase-type plasminogen activator 19
CAD 19
phosphatidylinositol 3-kinase 19
calcineurin 19
AMP-activated protein kinase 18
arginase 16
methionine synthase 16
kallikrein 15
methionine synthase 15
heme oxygenase 15
creatine kinase 15
collagenase 14
PAH 13
beta-galactosidase 13
PKG 13
proteasome 13
cholinesterase 13
aldose reductase 12
alanine aminotransferase 12
phospholipase C 11
lipase 11
lipoxygenase 11
reverse transcriptase 10
lactate dehydrogenase 10
neutrophil elastase 10
IKK 10
ACS 10
P-glycoprotein 9
AMPK 9
PDE 8
chymase 8
trypsin 8
aspartate aminotransferase 8
MMP 8
phosphoinositide 3-kinase 8
RNase 8
PTA 8
alpha-galactosidase 8
3-hydroxy-3-methylglutaryl coenzyme A reductase 8
MAP 8
adenylate cyclase 7
gamma-glutamyl transpeptidase 7
cholesterol acyltransferase 7
PDK1 7
diamine oxidase 7
RNase 7
monoamine oxidase 7
AMPK 7
papain 7
protein phosphatase 2A 7
12-lipoxygenase 7
endothelin-converting enzyme 7
ornithine decarboxylase 7
choline acetyltransferase 6
dimethylarginine dimethylaminohydrolase 6
insulin-degrading enzyme 6
PAT 6
caspase-1 6
transglutaminase 6
methionine synthase reductase 6
glutathione S-transferase 6
biliverdin reductase 5
homocysteine methyltransferase 5
lysozyme 5
neuraminidase 5
lecithin:cholesterol acyltransferase 5
aldehyde dehydrogenase 5
matrix metalloproteinase 2 5
meprin 5
ceruloplasmin 5
DNA methyltransferase 5
glutathione reductase 5
lysyl oxidase 5
tryptase 5
PPH 5
cathepsin B 5
hexosaminidase 5
cathepsin D 5
glucose-6-phosphate dehydrogenase 5
furin 5
pepsin 4
granzyme B 4
hyaluronidase 4
alpha-glucosidase 4
pyruvate dehydrogenase 4
matrix metalloproteinase 9 4
TAT 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
LPL 4
farnesyltransferase 4
pyruvate dehydrogenase 4
GSK 4
aldehyde dehydrogenase 4
proteinase K 4
pyruvate dehydrogenase 4
complex I 4
RNA polymerase 4
soluble epoxide hydrolase 3
S-adenosylmethionine decarboxylase 3
acid phosphatase 3
hyaluronidase 3
cathepsin G 3
glyceraldehyde-3-phosphate dehydrogenase 3
AST 3
cystathionine gamma-synthase 3
methionyl-tRNA synthetase 3
CYP3A4 3
ATP synthase 3
caspase-9 3
BAL 3
xanthine dehydrogenase 3
farnesyltransferase 3
CaMKII 3
cdc2 3
transcriptase 3
cathepsin S 3
uricase 3
gamma-glutamylcysteine synthetase 3
more...
Compound
Clin 1428
Dec 1172
glucose 728
oxygen 690
homocysteine 618
Cardiol 581
nitric oxide 559
DNA 362
calcium 333
methionine 193
creatinine 182
sodium 171
prostacyclin 162
arginine 156
water 153
Homocysteine 136
Homocysteine 136
phosphate 123
acetate 109
cysteine 105
ASA 103
ADP 102
Insulin 102
hydrogen 85
CO2 75
iron 75
TNF 74
aldosterone 74
ADP 71
ADP 71
sulfate 65
salt 65
Ang II 64
Angiotensin II 62
ATP 59
serine 59
potassium 59
Cholesterol 59
tyrosine 58
nitrogen 57
CAA 55
cGMP 55
zinc 53
lysine 52
Cereb 51
Dial 51
Congo red 50
Retinal 50
PGA 48
His 42
copper 42
urea 40
silver 39
Collagen 37
NADPH 34
NADPH 34
threonine 34
ethanol 34
vitamin D 33
nitrate 30
S-adenosylhomocysteine 29
adenosylmethionine 29
glutamate 28
leucine 28
H2O2 28
GSH 27
GSH 27
AMP 27
alanine 27
Diabetol 26
Estrogen 26
nicotinamide 25
NAD 25
THP 25
ACh 25
THP 25
galactose 24
glutamine 24
GMP 23
prostaglandin E1 23
cAMP 22
STZ 22
NAD 22
Diabetol 21
noradrenaline 21
betaine 21
Asp 21
superoxide radical 21
Fibrinogen 20
Estrogen 20
tryptophan 19
Optimal 17
DBP 17
proline 17
Pravastatin 17
phosphorus 17
nicotinic acid 17
aldehyde 17
DBP 17
Warfarin 17
tryptophan 16
EDTA 16
tryptophan 16
Pac 16
5-HT 16
tryptophan 16
EDTA 16
formic acid 15
formic acid 15
formic acid 15
Metformin 15
formic acid 15
formic acid 15
MEK 15
formic acid 15
N-acetylcysteine 15
formic acid 15
Metformin 15
Gly 15
alloxan 15
formic acid 15
selenium 15
formic acid 15
formic acid 15
AGE 15
Mg2+ 14
iodine 14
Fibrin 14
mercury 13
MTT 13
NADH 13
valine 13
Statin 13
formaldehyde 13
PAH 13
Phe 13
Heparin 12
H2S 12
SDS 12
Ile 12
aluminum 12
MDA 12
Thrombin 12
Methionine 12
Nicotine 11
bromide 11
Adenosine 11
Heme 11
Cyclosporine 11
MCA 11
MCA 11
barium 11
NH2 11
asparagine 11
ACS 10
palmitic acid 10
MAP 10
aldehyde 10
chromate 10
TOF 10
more...