Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Extensive plexuses of serotonin axons form a supra- and subependymal system in the walls of the ventricles, in the arachnoid sheath around major cerebral blood vessels, and in the pia over the spinal cord. These have been demonstrated by autoradiography after continuous intraventricular perfusions of exogenous [3H]5-HT in rats and monkeys. The axons accumulate 5,6-DHT rendering them electron opaque, but have no uptake systems for [3H]NE. After treatment with MAO inhibitors and [3H]5-HT, the axonal boutons contain large (70nm) variably dense synaptic vesicles, and small (35 nm) vesicles each equipped with a dense dot. The latter vesicles are not seen in untreated controls. Electrical stimulation in the raphe nuclei causes significant increases in axonal [3H]5-HT uptake indicating that the fibers originate in the raphe. Quantitatively, the supraependymal plexus is variable, profuse over the dorsal and ventral aqueductal surfaces, sparse over the lateral aspects. Individual raphe neurons have their specific uptake affinities for [3H]5-HT that are independent of tracer concentration or diffusion gradient. It is suggested that raphe neurons with low 5-HT uptake may utilize other neurotransmitters. Two new functional roles are proposed: (1) the serotonin ventricular and pial axons are probably important modifiers of local cerebrospinal fluid (CSF) composition so that regional CSF variations in 5-HT and its metabolites are highly probable; (2) the subarachnoid plexus around major cerebral vessels may contribute to local vasomotor action, thus affecting the cerebral blood flow. The possible significance of these serotonin systems for an understanding of certain neurological entities such as migraine and hemodynamic regulation in cerebral vascular disease is indicated.
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PMID:Serotonin axons in the supra- and subependymal plexuses and in the leptomeninges; their roles in local alterations of cerebrospinal fluid and vasomotor activity. 81 16

A radiologic-hemodynamic comparitive study was made in 51 cases of obliterative pulmonary vascular disease. The results showed that the pulmonary arterial pressures were all elevated when their radiologic parameters (RDB, RDB/B, PL/T, C/T, DPA/DHT) had abnormal changes, and they had higher sensitivity (76.5-92.2%), specificity (100%) and accuracy (81.8-93.9%) except for DPA/DHT, and there were certain correlations between radiologic parameters and pulmonary arterial pressures (r = 0.36-0.63, P < 0.05-0.01) except for PL/T. In conclusion the radiologic parameters can be used as qualitative diagnostic parameters for pulmonary hypertension in obliterative pulmonary vascular disease, and some parameters might be helpful for evaluating the level of pulmonary hypertension.
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PMID:[Comparison between radiograph and hemodynamics in obliterative pulmonary vascular disease]. 130 9