Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pulmonary metastasis of non small cell lung carcinomas are commonly nodular. The isolated nodular form must be diagnosed from double location carcinomas. The lymphangitic carcinomatosis semiology is best demonstrated with HR-CT-Technic. Endobronchic, alveolar and multi-micro angiopathy with emboli are less common.
Rev Mal Respir 1992
PMID:[Lung metastasis]. 133 76

Early onset vascular disease unexplained until today by usual risk factors (hyperlipidemia, hypertension, tobacco, stress), can now find an explanation in sulfur amino acid metabolism defect. By transsulfuration, alimentary methionine leads to homocysteine, which is itself turn into cysteine, or remethylated into methionine. Several abnormalities of these different pathways lead to plasma accumulation of homocysteine, which will be responsible of arterial or venous occlusive lesions, concerning peripheral or deep vessels. Homocysteine stays in plasma upon several forms: 75% being linked by disulfide bounds to proteins, 22% as disulfide, homocystine (homocysteine-homocysteine) or mixed-disulfide (homocysteine-cysteine), and less than 3% as free reduced homocysteine. Plasma reduction allows total homocysteine evaluation with amino acid autoanalyzer. The basal plasma homocysteine level is less than 14 microMl. However, levels near this basal value can be found in patients with latent abnormality, which needs to be revealed by a methionine loading test. This study concerns two methodologies and their application to the exploration of a patient with unidentified neurologic disorders. The first one describes a new galenic oral form of methionine. Other authors use the methionine load of 100 mg/kg dissolving it in a fruit juice glass. In order to obtain a complete dissolution of this weakly soluble substance and to ensure its total absorbtion by the patient, we prepare a granular form aimed to give in water a perfect flavoured suspension. The second methodology concerns methionine loading test and amino acid analysis. After 10 hours fasting, a 100 mg/kg peroral methionine load is realized performing 5 EDTA blood samples before and 4, 8, 12 and 24 hours after loading.(ABSTRACT TRUNCATED AT 250 WORDS)
J Mal Vasc 1991
PMID:[The homocysteinemia vascular risk factor. Methodologies and application to a clinical case]. 179 72

Pseudo-Kaposi's Sarcoma with vascular disease concern mainly acroangiodermatitis described by Mali--(with chronic venous insufficiency)--, arteriovenous malformations with angiodermatitis described by Stewart and Bluefarb, and pseudo-Kaposi's Sarcoma occurring after placement of arteriovenous shunt for hemodialysis. Search for relation ships between classical Kaposi's Sarcoma and new AIDS Kaposi's Sarcoma explains new interest devoted to Pseudo-Kaposi's Sarcoma.
J Mal Vasc 1991
PMID:[Pseudo-Kaposi syndromes of vascular origin]. 186 Nov 8

The right pulmonary artery arising from the proximal ascending aorta is a rare and severe malformation. This retrospective study of 11 children with this condition was undertaken to determine the conditions of diagnosis, to analyse the results of surgery, and, above all, to clarify the mechanism of the left pulmonary arterial hypertension which was always present. Ten of these patients were 4 to 90 days old. All had severe congestive cardiac failure with iso- or suprasystemic left pulmonary arterial hypertension. The only associated lesions were ventricular septal defect (1 case) and patent ductus arteriosus (7 cases). None of the patients had significant left-to-right shunts and only one had left atrial hypertension: this patient died before surgery could be performed. The other 9 patients underwent surgical correction and the pulmonary pressures immediately fell to normal or almost normal values. The child with the ventricular septal defect died of infection 6 weeks after surgery. The 8 survivors are doing well 1 month to 12 years later and left pulmonary pressures are normal in all, including those (5 cases) with a stenosed (4 cases) or completely occluded right pulmonary arterial circulation (1 case) and in 1 patient with obstructive vascular disease. The eleventh patient was very different: she had no signs or symptoms until 2 years of age, when a right pulmonary obstructive arterial disease but with normal left pulmonary pressures was documented. She was not operated on and remains well nine years later.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1991 May
PMID:[Right pulmonary artery arising from the proximal ascending aorta. A model of reflex pulmonary hypertension of the left lung?]. 189 98

Twenty five infants with truncus arteriosus underwent complete surgical correction in the first year of life between January 1984 and June 1990 at Marie Lannelongue Hospital. All had cardiac failure and pulmonary hypertension. Another severe cardiac malformation was present in 6 cases. Complete repair was carried out under cardiopulmonary bypass with moderate hypothermia. After closing the ventricular septal defect the continuity of the right ventricle and pulmonary artery was reestablished by a valved Dacron conduit with a bioprosthesis (13 patients), by an autologous pericardial conduit with the same type of prosthesis (5 patients), by a valveless conduit (1 patient) or by direct insertion of the pulmonary artery (6 patients). Eight children (32%) died shortly after surgery. Seventy one per cent of children operated in the first month of life died compared with only 17% of those operated after one month of life (p less than 0.05). The seventeen survivors have been followed up for an average of 21 +/- 22 months. Three secondary deaths were observed at 33 days, 2 and 10 months after surgery: the first child died of left ventricular failure and pulmonary vascular disease related to the complexity of the associated cardiac malformations; the other 2 deaths were unexpected. The one and three year survival rate is 54%. Pulmonary stenosis with a systolic pressure gradient of more than 30 mmHg was found in 7 patients of whom 6 had valved Dacron conduits (p less than 0.01). One child was successfully operated 60 months after the total correction and another child is on the waiting list for reoperation 69 months after the total correction.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch Mal Coeur Vaiss 1991 May
PMID:[Immediate and mid-term results of complete repair of truncus arteriosus during the first year of life]. 189 4

A new non-invasive methodology of measurement of pulsatile wall shear in superficial large arteries in man is presented from simple determinations of internal diameter of large artery and centerline instantaneous blood velocity (pulsed Doppler apparatus) and asymptotic blood viscosity (coaxial cylinder viscometer). Pulsatile distribution of velocity across the arterial lumen has been represented by a Womersley model enabling to define and calculate wall shear rate as the slope at the wall to the velocity profile at each cardiac time. These complex mathematical calculations have been performed on micro-computer by means of appropriate programmation according to the following steps (1) Digitization and processing of instantaneous centerline blood velocity (2) Decomposition of velocity signal into Fourier series as a sum of elementary velocity sinusoids of increasing frequency (3) computation of velocity profile and slope at the wall to the profile for each harmonic (4) Resynthetization of instantaneous wall shear rate as function in time (5) calculation of wall shear stress by multiplying wall shear rate by blood viscosity. Taking the brachial artery as model of peripheral large artery, pulsatile wall shear rate and stress curves were determined in individual subjects and analysed by means of several characteristic indices including: maximum, minimum and mean values; time of systolic increase and time of systolic relaxation; and oscillating index defined from the positive and negative surfaces of the shear curve. This original methodology open new way for studying hemodynamical conditions at the interface between blood and endothelium surface of large arteries and might be applied to the physiopharmacological approach of vascular disease such as hypertension.
Arch Mal Coeur Vaiss 1990 Jul
PMID:[A new hemodynamic endothelial approach using non-invasive evaluation of instantaneous wall shear in human arteries. Application in arterial hypertension]. 214 77

The popliteal fossa is a relatively small, muscle-bound strategic anatomical area where is found, on the posterior aspect of the knee, a vasculonervous pedicle and where both vascular and pseudovascular disease may develop, the latter originating from wall-constituting parts. Among non-typical popliteal diseases, the authors have singled out four rare syndromes. The popliteal vein may be trapped due to fibrous strangulation or, more often, to compression by the hypertrophied gastrocnemius muscle. This requires proper diagnosis and surgical management prior to thrombosis onset. Synovial cysts raise no diagnostic problems, unless they mimic an episode of phlebitis; echotomography has now become essential for diagnosis. Desmoid tumors for which predominant extra-abdominal occurrence sites are the popliteal fossa, the leg and thigh, are difficult to excise completely, especially at the popliteal level, and are a major technical challenge because of the inclusion of the vasculonervous pedicle. Lastly, in sports pathology, one must be able to recognize the painful fabella syndrome (osteochondritis of sesamoid fibrocartilage in lateral head of gastrocnemius), so as not to mistakenly implicate vascular disease. New developments in imaging (namely, real time CT-echography) are of major help to clinicists, who should, nonetheless, remain chiefly responsible for detecting these diseases.
J Mal Vasc 1990
PMID:[Popliteal vein entrapment, popliteal cyst, desmoid tumor and fabella syndrome]. 219 86

The authors report a case of total anomalous pulmonary venous return (TAPVR) draining into the innominate (brachiocephalic) vein, discovered in a 40-year old male patient and successfully treated by surgery. This type of cardiopathy is usually suspected in the neonatal period, being badly tolerated, and such a prolonged survival is quite exceptional. Survival is conditioned by the site of the TAPVR, by the size of the atrial septal defect and also by the presence or absence of an obstacle to the pulmonary venous return and of pulmonary arterial hypertension. In the absence of pulmonary vascular disease, surgical correction is mandatory and results in regression of the symptoms and of the pulmonary arterial hypertension.
Arch Mal Coeur Vaiss 1989 May
PMID:[Total abnormal pulmonary venous return surgically treated in an adult]. 250 Jan 8

The aim of this study was to assess and compare microalbuminuria (mu Alb mg/24 h +/- SD) in populations with hypertension and or diabetes mellitus leading to determine the effects of each pathology and their association in nephropathy. In hospital population studies were (mean +/- S.D.): (table; see text) No other pathology was found. Creatinine was in normal limits and macroproteinuria less than 1 g/24 h. Microalbuminuria was measured with laser immunonephelemetry. Glucose tolerance was assessed by fructosaminemia values (N less than or equal to 2.8 mmol/l). Student's test and linear regression test were used. There was no correlation between microalbuminuria and the other parameters: fructosamine, creatinine, age, in the 5 groups. Early nephropathy defined as a value of microalbuminuria between 30 and 300 mg/24 h was found in 23 p. 100 (H), mean 64.4 mg/24 h +/- 44, 37 p. 100 (D1), mean 127.7 +/- 149, 29 p. 100 (D2) mean 95.5 +/- 88, 47 p. 100 (D1H) mean 96.8 +/- 72, 39 p. 100 (D2H) mean 90 +/- 70. Microalbuminurias in diabetic populations were upper than in hypertensive (NS). Early nephropathy was most frequent when hypertension was associated with diabetes. Follow-up and treatment of hypertension in populations at high risk of vascular disease, as diabetics, will probably decrease the prevalence of early nephropathy.
Arch Mal Coeur Vaiss 1989 Jul
PMID:[Roles of arterial hypertension and diabetes mellitus in early nephropathy]. 251 Jun 49

The calcium antagonists are currently used in the treatment of Raynaud's syndrome for patients with scleroderma. The effect on the pulmonary vasculature in these patients is little understood. The study reported here is based on 15 patients with scleroderma. In each patient lung volumes, expiratory flow and transfer factor (DLCO) were carried out in a basal state and one hour after the administration of sub lingual nifedipine. Nine patients showed a diminution in the DLCO before taking the product but the mean variation after nifedipine was not significant. Different mechanisms may explain the absence of any effect: irreversible vascular disease or the absence of pulmonary arterial hypertension or hypoxic constriction, the latter conditions were previously associated with the efficacy of nifedipine. Thus it does not seem that nifedipine, in acute tests, has an effect on the pulmonary localisation of scleroderma, at least in the absence of pulmonary arterial hypertension.
Rev Mal Respir 1989
PMID:[Effect of a single dose of nifedipine on the CO transfer capacity in patients with scleroderma]. 260 27


1 2 3 4 5 6 7 Next >>