Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Drug therapy of asthma in the elderly with sympathomimetics, theophylline, steroids, and mucokinetic agents is described, with discussion of dosage evaluation, toxicity, possible drug interactions, and suggested management of common problems. The aspirin hypersensitivity syndrome is reviewed, with an admonition to avoid this drug in asthmatic patients who have nasal polyps, nasal obstruction, or sinusitis, especially patients over the age of 30. The treatments of coughs and colds, and common respiratory infections such as tuberculosis and bronchitis, in the elderly are also outlined. Antihistamines are not advised for elderly patients who have viral or bacterial infections of the nose or throat, and oral preparations containing nasal mucosal vasoconstrictors should also be avoided in managing the elderly patient who has hypertension, vascular disease, or prostatism. Cough suppressants must be used with care, especially if cough is associated with chronic obstructive pulmonary disease. Special attention is given to the role of oxygen therapy for chronic obstructive pulmonary disease.
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PMID:Management of respiratory problems in the aged. 713 May 88

The treatment of hypertension in the elderly can be safely achieved with low-dose diuretic therapy. Men with prostatism may benefit from peripheral alpha-blocking drugs. However, drugs such as doxazosin or terazosin may further lower blood pressure and at times may be associated with orthostatic hypotension, especially if diuretics are given concomitantly. Tamsulosin achieves relaxation of the smooth muscle of the prostate, as do terazosin and doxazosin, but without provoking changes in blood pressure, especially orthostatic hypotension. There appears to be no adverse interaction with any other antihypertensive medication or with low-dose diuretics. To manage such patients with hypertension and prostatism, hydrochlorothiazide 6.25 to 12.5 mg/day and tamsulosin 0.4 mg/day would be an adequate combination. Low-dose diuretics have been shown to be effective in both isolated systolic hypertension as well as fixed diastolic hypertension in the elderly. If other antihypertensives need to be added, then a low dose of a long-acting calcium-entry blocker, a central alpha-agonist (a transdermal clonidine for better compliance), an angiotensin-converting enzyme inhibitor (if renal vascular disease has been ruled out), or an angiotensin II receptor blocker, e.g., losartan or valsartan, should be considered.
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PMID:Hypertension in the elderly with coexisting benign prostatic hyperplasia. 1009 95