Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0042373 (vascular disease)
 17,070 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Recent data have indicated that hormone replacement therapy (HRT) is associated with an increased risk of venous thrombo-embolism. Although the relative risk is significantly higher, the absolute risk remains small. Epidemiological studies on which the increased risk was based may have been open to biases, including those of referral, investigation and diagnosis. None the less, the association appears real albeit the mechanism poorly understood. Potential mechanisms include unmasking of an underlying thrombophilia or combination with other recognized risk factors for venous thrombo-embolism. The implications of these findings have to be placed firmly in the clinical context and weighed against the established benefits of hormone replacement therapy, including relief of menopausal symptoms, prevention of osteoporosis and arterial-vascular disease. Patients with a personal or family history of venous thrombo-embolism should be screened for underlying thrombophilia and such screening may be extended to relatives. However, the risk of venous thrombo-embolism following initiation of HRT is not yet known. None the less, HRT should be used with caution in this situation and may be best avoided, unless associated with concomitant antithrombotic therapy, in certain thrombophilias, expert advice should be sought. Patients without risk factors should be advised of the small increase in risk of venous thrombosis which is greatest during the first year. Where additional risk factors are present the situation will have to be assessed on an individual basis for each patient. For example, the beneficial effects of HRT in an obese patient at risk of arterial disease may outweigh the small risk of thrombosis. Patients already on HRT should have some assessment of the risk of venous thrombosis made and where there are features suggestive of thrombophilia screening performed.
 ...
PMID:Venous thrombo-embolism and hormone replacement therapy. 948 93

Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of bone mass with continuing oestrogen therapy and reduction of subsequent risk of fracture is well established. Observational studies of the metabolic and vascular effects of oestrogens have suggested a potential benefit in reducing the risk of vascular disease, but recently published randomized controlled trials demonstrate no evidence of benefit in women with established vascular disease or in apparently healthy women. The increased risks of breast cancer and thromboembolic disease have been confirmed in these trials, with evidence of increased risk of stroke. Observational data suggest there may be a small increased risk of ovarian cancer associated with longer-term use of HRT. The premature termination of one arm of the Women's Health Initiative randomized controlled trial caused concern among patients, doctors and pharmaceutical companies. There are difficulties in extrapolating the results from trials using a specific HRT product to advise women on the wide range of other hormone products, doses, combinations and routes of administration. However, in the absence of evidence that other products are safer, the data suggest that for many women the risks associated with long-term use of HRT outweigh the benefits. There are nonhormonal strategies for the prevention and treatment of osteoporosis. HRT is not, and has never been, licensed in the UK for the prevention or treatment of vascular disease, and the data suggesting potential benefit should now be regarded as biased. The absolute incidence of an adverse event is low, and the risk in an individual woman in a single year is very small, but the risks are cumulative over time with long-term use. The risk-benefit balance of each woman needs regular reappraisal with continued use.
 ...
PMID:Recent concerns surrounding HRT. 1286 90

Although estrogen has been clinically available for more than six decades, women have been confused by different opinions regarding the risks and benefits of menopausal hormone therapy (HT), estrogen therapy (ET), and estrogen-progestin therapy (EPT). The publication of randomized controlled trials (RCTs), notably, the Heart and Estrogen/progestin Replacement Study (HERS) and Women's Health Initiative (WHI), has intensified the risk vs. benefit controversy. Millions of women are treated with HT for relief of menopausal symptoms, including vasomotor flushes and sweats, for which estrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HT will help to prevent chronic disease. The preservation of bone mass with continuing estrogen therapy and reduction of subsequent risk of fracture is well established. Observational studies of the metabolic and vascular effects of estrogens have suggested a potential benefit in reducing the risk of vascular disease, but recently published randomized controlled trials demonstrated no evidence of benefit in women with established vascular disease or in apparently healthy women. The increased risks of breast cancer and thromboembolic disease have been confirmed in these trials, with evidence of increased risk of stroke. The absolute incidence of an adverse event is low, and the risk of stroke in an individual woman in a single year is very small, but with long-term use, the risks are cumulative over time. The risk-benefit balance needs to be individualized for each woman.
...
PMID:[Hormone replacement therapy in menopause]. 2483 May 94